CD9+ and CD82+ extracellular vesicles in synovial fluid differentiate aseptic from septic endoprosthesis loosening [0.03%]
CD9和CD82阳性细胞外囊泡鉴别无菌性与细菌性人工关节置换术后假体松动
Tobias Tertel,Vera Rebmann,Charlotte Bielefeld et al.
Tobias Tertel et al.
Aim: Extracellular vesicles (EVs) hold great promise as emerging biomarkers for a variety of diseases. However, their clinical application is still hindered by complex and time-consuming isolation procedures. A clinically relevant scenario ...
Enrico Ragni,Enrico Lucarelli,Stefano Grolli et al.
Enrico Ragni et al.
Extracellular vesicles as vehicles for small non-coding RNA therapeutics: standardization challenges for clinical translation [0.03%]
作为小非编码RNA治疗载体的细胞外囊泡：临床转化的标准挑战
Lucrezia Luisotti,Lorenzo Germelli,Rebecca Piccarducci et al.
Lucrezia Luisotti et al.
Aim: Extracellular vesicles (EVs) have emerged as promising vehicles for the delivery of small non-coding RNAs (sncRNAs); however, their clinical translation is hindered by the lack of standardized manufacturing methods, RNA loading protoco...
Enrico Ragni,Rita Romani,Valentina Grespi et al.
Enrico Ragni et al.
The GISM Annual Meeting 2025 convened experts in regenerative medicine and nanomedicine to discuss recent advances in mesenchymal stromal/stem cell (MSC) research and extracellular vesicle (EV) technologies. The meeting emphasized novel str...
The 4th annual American Society for Intercellular Communication (ASIC) meeting, 2024 conference report [0.03%]
2024年美国细胞间通讯协会(ASIC)第四次年度会议报告
Ashley E Russell,Aurelio Lorico
Ashley E Russell
Microfluidic devices for on-chip quantification of extracellular vesicles and associated biomarkers [0.03%]
片上量化细胞外囊泡及其相关生物标志物的微流体装置
Víctor Calero,Carlos Honrado,Alar Ainla et al.
Víctor Calero et al.
In the past decade, extracellular vesicles (EVs) have gained increasing attention in biomedical research. These membrane-bound particles are naturally secreted by cells under both physiological and pathological conditions, and they exhibit ...
Stem-cell-derived extracellular vesicles in neurodegeneration and neuroaging: therapeutic potential and challenges [0.03%]
干细胞来源的细胞外囊泡在神经退行性和神经老化中的治疗潜力与挑战
Mohit Kumar,Sudipta Ray,Susmita Sil
Mohit Kumar
Neuroaging is a complex biological process in which the brain undergoes progressive functional decline marked by synaptic loss, neuroinflammation, and cognitive decline. At the molecular and cellular level, aging is driven by multiple inter...
Exosome miRNA sorting controlled by RNA-binding protein-motif interactions [0.03%]
受RNA结合蛋白-基序相互作用控制的外泌体miRNA分类投放
Zixuan Huang,Xuan Zhao,Wenjing Wen et al.
Zixuan Huang et al.
Exosomes, as key mediators of intercellular communication, have shown great potential in disease intervention and therapy in recent years. As natural nanocarriers, exosomes play a crucial role in transporting a wide array of cargo. Among th...
Beyond preclinical promise: can mesenchymal stromal cell-derived extracellular vesicles reliably target tubular epithelial cells? [0.03%]
超越药效学承诺：间充质基质细胞来源的外泌体能否可靠地靶向管状上皮细胞？
Linrong Pan,Sergio G Garcia,Miriam Font-Morón et al.
Linrong Pan et al.
Kidney disease, encompassing both acute kidney injury (AKI) and chronic kidney disease (CKD), represents a major global health challenge. A pivotal aspect of the pathogenesis of these conditions is damage to renal tubular epithelial cells (...
Overproduction of β-barrel outer membrane proteins in Escherichia coli BL21(DE3) induces hypervesiculation [0.03%]
大肠杆菌BL21（DE3）中蛋白质过度生产诱导细胞膜产生过多微泡现象
Saloni Sahu,Gregory Koningstein,Catalin M Bunduc et al.
Saloni Sahu et al.
Aim: Gram-negative bacteria release outer membrane vesicles (OMVs) that fulfill many functions including survival during stress conditions, delivery of virulence factors, and nutrient acquisition. Additionally, they are increasingly used as...