Benjamin I Burke,John J McCarthy,Ahmed Ismaeel
Benjamin I Burke
A recent study from Liu et al. described the role of skeletal muscle-derived extracellular vesicles in promoting liver fibrosis as an outcome of chronic overtraining in mice. Here, we highlight this work and discuss its implications within ...
Carine de Marcos Lousa
Carine de Marcos Lousa
Lignin is an important component of plant cell walls, providing structural support and defense. Despite extensive research, the mechanisms underlying the transport and polymerization of lignin precursors remain poorly understood. Kankaanpä...
Optimized size exclusion chromatography demonstrates that extracellular vesicles are the key RNA carriers of ALK translocations in non-small cell lung cancer cell line secretome and patient plasma [0.03%]
优化尺寸排除色谱法证明外泌体是ALK重排非小细胞肺癌细胞系分泌组和患者血浆中RNA的关键载体
Beatriz Benayas,Estela Sánchez-Herrero,Lucía Robado de Lope et al.
Beatriz Benayas et al.
Aim: Identification of ALK fusions in non-small cell lung cancer (NSCLC) is key to determining eligibility for treatment with ALK inhibitors that markedly improve patients' quality of life and survival outcomes. Circulating RNA, associated ...
Giulia Chiabotto,Armina Semnani,Elena Ceccotti et al.
Giulia Chiabotto et al.
Liver fibrosis is a progressive condition characterized by excessive scar tissue buildup, leading to impaired liver function and potentially cirrhosis. Despite advancements in treatment strategies, effective anti-fibrotic therapies remain a...
Exosomal miR-302b as a novel strategy for reversing cellular senescence and promoting healthy aging [0.03%]
外泌体miR-302b可通过逆转细胞衰老促进健康老龄化的新策略
Consuelo Borrás
Consuelo Borrás
The study by Bi et al. (2025) presents "Senoreverse", an innovative strategy that utilizes exosomal miR-302b to restore the proliferative capacity of senescent cells (SnCs), thus extending lifespan and enhancing cognitive and physical funct...
Therapeutic potential of extracellular vesicles for treating human pregnancy disorders [0.03%]
细胞外囊泡治疗人类妊娠疾病的潜力
Shixuan Zheng,Harry M Georgiou,Maria I Kokkinos et al.
Shixuan Zheng et al.
Pregnancy complications such as preeclampsia and fetal growth restriction are major global health concerns, contributing to significant maternal and fetal morbidity and mortality. These disorders also increase the long-term risk of cardiova...
Secretome and extracellular vesicle signatures in bone marrow-derived mesenchymal stromal cells after expansion in standard and next-generation media [0.03%]
常规和新一代培养基扩增的骨髓来源间充质基质细胞的分泌组和外泌体标志物分析
Giulio Grieco,Simona Piccolo,Enrico Ragni et al.
Giulio Grieco et al.
Aim: Mesenchymal stem cells (MSCs) are a promising therapeutic strategy for osteoarthritis (OA), largely due to their regenerative potential, which is attributed in part to their secretome. The secretome includes soluble factors and extrace...
Tumor microenvironment: new era in exosomal circRNA research - a bibliometric analysis [0.03%]
肿瘤微环境：circRNA外泌体研究新时代——文献计量分析
Hai-Quan Wang,Lu Zhang,Ming-Jie Li et al.
Hai-Quan Wang et al.
Aim: The domain of exosomal circRNAs has seen rapid growth over the past few years, yet a thorough synthesis of the scholarly contributions has been lacking. This study employs bibliometric analysis to uncover the focal points and trends in...
Small extracellular vesicles, their cargo, and oxidative stress: emerging biomarkers for glaucoma diagnosis and treatment [0.03%]
小型细胞外囊泡、其货物及氧化应激：青光眼诊断与治疗的新兴生物标志物
Francisco J Romero,Manuel Diaz-Llopis
Francisco J Romero
The contribution commented on is a relevant bridging work between extracellular vesicles, oxidative stress, and proteomics (especially regarding biomarkers) research. The findings reported are promising but further point out one of the futu...
Bovine milk extracellular vesicles prepared by ultracentrifugation contain microbial mRNAs that do not accumulate in human plasma following milk consumption [0.03%]
超速离心制备的牛乳细胞外囊泡中含有微生物mRNA，在人类饮用牛奶后不会在血浆中积累
Peerzada T Mumtaz,Bijaya Upadhyaya,Jiang Shu et al.
Peerzada T Mumtaz et al.
Aim:Small extracellular vesicles (sEVs) and their RNA cargo are not exclusively derived from endogenous synthesis but can also be absorbed from milk and gut bacteria. Given the high rate of bacterial fermentation in the gastrointestinal tra...