Exosome miRNA sorting controlled by RNA-binding protein-motif interactions [0.03%]
受RNA结合蛋白-基序相互作用控制的外泌体miRNA分类投放
Zixuan Huang,Xuan Zhao,Wenjing Wen et al.
Zixuan Huang et al.
Exosomes, as key mediators of intercellular communication, have shown great potential in disease intervention and therapy in recent years. As natural nanocarriers, exosomes play a crucial role in transporting a wide array of cargo. Among th...
Beyond preclinical promise: can mesenchymal stromal cell-derived extracellular vesicles reliably target tubular epithelial cells? [0.03%]
超越药效学承诺：间充质基质细胞来源的外泌体能否可靠地靶向管状上皮细胞？
Linrong Pan,Sergio G Garcia,Miriam Font-Morón et al.
Linrong Pan et al.
Kidney disease, encompassing both acute kidney injury (AKI) and chronic kidney disease (CKD), represents a major global health challenge. A pivotal aspect of the pathogenesis of these conditions is damage to renal tubular epithelial cells (...
Overproduction of β-barrel outer membrane proteins in Escherichia coli BL21(DE3) induces hypervesiculation [0.03%]
大肠杆菌BL21（DE3）中蛋白质过度生产诱导细胞膜产生过多微泡现象
Saloni Sahu,Gregory Koningstein,Catalin M Bunduc et al.
Saloni Sahu et al.
Aim: Gram-negative bacteria release outer membrane vesicles (OMVs) that fulfill many functions including survival during stress conditions, delivery of virulence factors, and nutrient acquisition. Additionally, they are increasingly used as...
UKEV forum 2024: The UK Society for Extracellular Vesicle annual meeting - bridging innovation and impact [0.03%]
英国 extracellular vesicle 社区 2024 年度大会：连接创新与影响
Hannah K Jackson,Naveed Akbar,Nick Peake et al.
Hannah K Jackson et al.
In December 2024, the United Kingdom Society for Extracellular Vesicles (UKEV) held its annual forum in Newcastle upon Tyne, marking 11 years since its founding. UKEV Forum 2024 brought together over 230 participants from the UK and abroad ...
Tear-derived extracellular vesicles as diagnostic biomarkers for ocular and neurodegenerative diseases: opportunities and challenges [0.03%]
泪源性细胞外囊泡作为眼部和神经退行性疾病诊断生物标志物的机会与挑战
Marta Sanroque-Muñoz,Sergio G Garcia,Linrong Pan et al.
Marta Sanroque-Muñoz et al.
In recent years, the prevalence of ocular diseases has increased considerably. However, timely diagnosis and treatment are hampered by the challenge of early detection since symptoms often appear in advanced stages. Emerging research highli...
Extracellular vesicles: cargo loading, degradation and secretory pathways, and their intersection with autophagy [0.03%]
细胞外囊泡：装载、降解和分泌途径及其与自噬的相互作用
Jinzhe Ju,Sophie M L Neuen,Marc van Zandvoort et al.
Jinzhe Ju et al.
Extracellular vesicles (EVs) are secreted by nearly all cell types and fulfil a crucial role in intercellular communication by transporting diverse cargo, including enzymes, mRNA, growth factors, chemokines, and cytokines. Although EVs were...
Reproducibility and transparency: why following MISEV guidelines is beneficial for the studies on EVs and brain barriers [0.03%]
可重复性和透明度：为何遵循MISEV指南对研究EV和脑屏障有益
Julien Saint-Pol
Julien Saint-Pol
A new hope for pulmonary hypoplasia: amniotic fluid stem cell extracellular vesicles? [0.03%]
肺发育不全的新希望：羊水干细胞外泌体？
Ishara Atukorala,Lisa Hui
Ishara Atukorala
In a recent study, Antounians and colleagues (2024) investigated the potential of amniotic fluid stem cell-derived extracellular vesicles (AFSC-EVs) as a therapeutic intervention for pulmonary hypoplasia resulting from congenital diaphragma...
Ying Gao,Tiebang Kang
Ying Gao
Blebbisomes represent a newly identified class of large extracellular vesicles (EVs) that exhibit unique functional capabilities in intercellular communication. Beyond their motility, blebbisomes engage in complex vesicle trafficking functi...
Hui Lu,Jin Zhang,Tianzhuo Shen et al.
Hui Lu et al.
Extracellular vesicles (EVs) are a type of cell-released phospholipid bilayer nanoscale carrier. However, research on EVs encounters several challenges, such as their heterogeneity, the complexities associated with their isolation and ident...