A single-sEV analysis identifies plasma EPCAM+ sEVs as a biomarker for early diagnosis and monitoring postoperative remission of thyroid cancer [0.03%]
单个sev分析识别出血浆EPCAM+sEV作为甲状腺癌早期诊断和术后缓解期监测生物标志物的能力
Simin Yu,Yuting Luo,Tianfeng Dang et al.
Simin Yu et al.
Aim: Small extracellular vesicles (sEVs) are promising noninvasive biomarkers for several malignancies, including thyroid carcinoma (TC). However, their heterogeneity is frequently overlooked in bulk-level analyses. Methods: Plasma samples ...
Rethinking miRNAs in MSC-sEV therapeutics: implications for manufacture, mechanism of action, and development of robust potency CQAs [0.03%]
从MSC-sEV疗法的角度重新思考miRNA：对制造、作用机制以及稳健效力CQAs发展的启示
Thong Teck Tan,Sai Kiang Lim
Thong Teck Tan
Mesenchymal stromal cell-derived small extracellular vesicles (MSC-sEVs) have emerged as a promising cell-free alternative to MSC-based therapies, offering superior safety, scalability, and stability profiles. These nanosized vesicles are n...
The extracellular vesicles of boar seminal plasma contain oxytocin at levels associated with fertility [0.03%]
公猪精浆的细胞外囊泡含有与生育力相关的催产素水平
Ana Parra,Pablo Martínez-Díaz,María Botía et al.
Ana Parra et al.
Aim: Pig seminal plasma (SP) contains oxytocin (OXT) at levels associated with the fertility outcomes of boars used for artificial insemination (AI). However, OXT easily volatilizes when circulating freely, making it difficult to maintain s...
Preanalytical framework for routine clinical use of liquid biopsies: combining EVs and cfDNA [0.03%]
结合外泌体和cfDNA的液体活检常规临床使用的前分析框架
Nike K Simon,Stefanie Volz,Jussara Rios de Los Rios Reséndiz et al.
Nike K Simon et al.
Aim: Liquid biopsies hold significant potential for the minimally invasive diagnosis of tumors and other diseases. While the clinical application of cell-free DNA (cfDNA) methodologies is emerging, the implementation of tumor-derived extrac...
Tumor-targeted multifunctional extracellular vesicles as drug carriers for lung cancer therapy [0.03%]
肿瘤靶向多功能细胞外囊泡肺癌药物载体治疗研究
Narsireddy Amreddy,Akhil Srivastava,Natascha Riedinger et al.
Narsireddy Amreddy et al.
Aim: Chemotherapy continues to be the frontline treatment for lung cancer patients. However, treatment-related toxicity and off-target effects limit the use of chemotherapy. Therefore, improvements in delivering chemotherapeutics with reduc...
Extracellular vesicles from ovarian cancer tumor spheroids harbor disease-related and survival-associated proteins [0.03%]
卵巢癌肿瘤球体的细胞外囊泡含有与疾病相关和生存相关的蛋白质
Christian Preußer,Max Gläser,Johannes Graumann et al.
Christian Preußer et al.
Aim: Extracellular vesicles (EVs) play a pivotal role in tumor progression, influencing the tumor microenvironment. Despite significant research, the targeted analysis of EVs directly derived from primary tumors remains limited, particularl...
HIV protein Nef expression in human microglia drives the release of distinct Nef-containing extracellular vesicles [0.03%]
人类小胶质细胞中HIV蛋白Nef的表达驱动释放不同类型的含Nef外泌体
Teja Lavrin,Jure Loboda,Jana Ferdin et al.
Teja Lavrin et al.
Aim: Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) persist in effectively treated HIV-infected individuals, in part due to HIV reservoirs in brain microglia, which express low levels of viral proteins such as...
Synergistic potentials of small extracellular vesicles, biomaterials, and 3D bioprinting in periodontal regeneration: a scoping review [0.03%]
小细胞外囊泡、生物材料和三维生物打印在牙周组织再生中的协同潜力：范围性综述
Chenyi Zhang,Chun Liu,Andrew Liaw et al.
Chenyi Zhang et al.
Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of both soft (gingiva and periodontal ligament) and hard (cementum and alveolar bone) supporting tissues. The complex periodontal microenvironment ...
Nan Yang,Yucui Wang,Hailong Liu et al.
Nan Yang et al.
In the rapidly developing field of skin care, non-surgical facial aesthetics are becoming increasingly favored by consumers. Plant-derived extracellular vesicles (PDEVs) have attracted much attention due to their low toxicity, cellular comm...
Extracellular vesicles from bacteria and fungi: mechanistic insights and implications for urinary tract infections [0.03%]
来源于细菌和真菌的细胞外囊泡：机制见解及其对泌尿系统感染的影响
Eddie Chung-Ting Chau,Pak-Ting Hau,Michaela Murillo et al.
Eddie Chung-Ting Chau et al.
Urinary tract infections (UTIs) pose a significant public health challenge, affecting approximately 407 million people worldwide and causing substantial morbidity and approximately 237,000 deaths. Bacteria and fungi represent the most frequ...