Comparative analysis of adipose-, bone marrow-, and amniotic membrane-derived MSC secretomes and EVs reveals shared and source-specific therapeutic signatures for osteoarthritis [0.03%]
比较分析来源于脂肪、骨髓和羊膜的间充质干细胞分泌组及外泌体揭示了软骨修复中的通用及特异性治疗标志物用于膝关节炎
Enrico Ragni,Andrea Papait,Michela Maria Taiana et al.
Enrico Ragni et al.
Aim: Mesenchymal stromal cells (MSCs) exert their therapeutic effects in osteoarthritis (OA) primarily through paracrine signaling, including secreted proteins and extracellular vesicle (EV)-associated microRNAs (miRNAs). However, the contr...
MISEV and MIQE: integrating domain-specific and general standards to strengthen extracellular vesicle biomarker research [0.03%]
MISEV和MIQE：整合领域特定和通用标准以加强外泌体生物标志物研究
Michael W Pfaffl,Mikael Kubista,Jo Vandesompele et al.
Michael W Pfaffl et al.
Extracellular vesicles (EVs) have significant potential as therapeutic agents and as sources of diagnostic, predictive, and prognostic nucleic acid biomarkers. However, variability in EV workflows and inadequate standardization of downstrea...
UKEV Forum 2024: the UK Society for Extracellular Vesicles Annual Meeting - Abstracts [0.03%]
2024英国外泌体协会年会(UKEV论坛) - 摘要集
Hannah K Jackson,Naveed Akbar,Nick Peake et al.
Hannah K Jackson et al.
A single-sEV analysis identifies plasma EPCAM+ sEVs as a biomarker for early diagnosis and monitoring postoperative remission of thyroid cancer [0.03%]
单个sev分析识别出血浆EPCAM+sEV作为甲状腺癌早期诊断和术后缓解期监测生物标志物的能力
Simin Yu,Yuting Luo,Tianfeng Dang et al.
Simin Yu et al.
Aim: Small extracellular vesicles (sEVs) are promising noninvasive biomarkers for several malignancies, including thyroid carcinoma (TC). However, their heterogeneity is frequently overlooked in bulk-level analyses. Methods: Plasma samples ...
Rethinking miRNAs in MSC-sEV therapeutics: implications for manufacture, mechanism of action, and development of robust potency CQAs [0.03%]
从MSC-sEV疗法的角度重新思考miRNA：对制造、作用机制以及稳健效力CQAs发展的启示
Thong Teck Tan,Sai Kiang Lim
Thong Teck Tan
Mesenchymal stromal cell-derived small extracellular vesicles (MSC-sEVs) have emerged as a promising cell-free alternative to MSC-based therapies, offering superior safety, scalability, and stability profiles. These nanosized vesicles are n...
The extracellular vesicles of boar seminal plasma contain oxytocin at levels associated with fertility [0.03%]
公猪精浆的细胞外囊泡含有与生育力相关的催产素水平
Ana Parra,Pablo Martínez-Díaz,María Botía et al.
Ana Parra et al.
Aim: Pig seminal plasma (SP) contains oxytocin (OXT) at levels associated with the fertility outcomes of boars used for artificial insemination (AI). However, OXT easily volatilizes when circulating freely, making it difficult to maintain s...
Preanalytical framework for routine clinical use of liquid biopsies: combining EVs and cfDNA [0.03%]
结合外泌体和cfDNA的液体活检常规临床使用的前分析框架
Nike K Simon,Stefanie Volz,Jussara Rios de Los Rios Reséndiz et al.
Nike K Simon et al.
Aim: Liquid biopsies hold significant potential for the minimally invasive diagnosis of tumors and other diseases. While the clinical application of cell-free DNA (cfDNA) methodologies is emerging, the implementation of tumor-derived extrac...
Tumor-targeted multifunctional extracellular vesicles as drug carriers for lung cancer therapy [0.03%]
肿瘤靶向多功能细胞外囊泡肺癌药物载体治疗研究
Narsireddy Amreddy,Akhil Srivastava,Natascha Riedinger et al.
Narsireddy Amreddy et al.
Aim: Chemotherapy continues to be the frontline treatment for lung cancer patients. However, treatment-related toxicity and off-target effects limit the use of chemotherapy. Therefore, improvements in delivering chemotherapeutics with reduc...
Extracellular vesicles from ovarian cancer tumor spheroids harbor disease-related and survival-associated proteins [0.03%]
卵巢癌肿瘤球体的细胞外囊泡含有与疾病相关和生存相关的蛋白质
Christian Preußer,Max Gläser,Johannes Graumann et al.
Christian Preußer et al.
Aim: Extracellular vesicles (EVs) play a pivotal role in tumor progression, influencing the tumor microenvironment. Despite significant research, the targeted analysis of EVs directly derived from primary tumors remains limited, particularl...
HIV protein Nef expression in human microglia drives the release of distinct Nef-containing extracellular vesicles [0.03%]
人类小胶质细胞中HIV蛋白Nef的表达驱动释放不同类型的含Nef外泌体
Teja Lavrin,Jure Loboda,Jana Ferdin et al.
Teja Lavrin et al.
Aim: Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) persist in effectively treated HIV-infected individuals, in part due to HIV reservoirs in brain microglia, which express low levels of viral proteins such as...