A novel extracellular vesicle isolation method based on cellulose nanofiber sheets [0.03%]
一种基于纤维素纳米纤维片的新颖细胞外囊泡分离方法
Yukari Nagao,Hiroaki Kajiyama,Akira Yokoi
Yukari Nagao
Extracellular vesicles (EVs) circulate in body fluids, carrying molecular cargo from their parent cells and exerting diverse biological functions. Consequently, they have attracted considerable attention as biomarkers for disease detection ...
Verification of the predictive value of EV-associated biomarkers MMP9 and CEACAM1 in rehabilitation of ischemic stroke [0.03%]
基质金属蛋白酶9和细胞黏附分子-1预测缺血性卒中康复的疗效价值的验证研究
Jiao Luo,You Cai,Yanling Cai et al.
Jiao Luo et al.
Aim: Extracellular vesicles (EVs) contribute to stroke rehabilitation by mediating intercellular signaling during inflammation and tissue repair. Here we report EV-associated surface proteins as potential biomarkers for predicting recovery ...
Human umbilical cord mesenchymal stem cell-derived nanovesicles ameliorate acute lung injury by hsa-let-7g-5p inhibition of NF-κB/NLRP3 pathway [0.03%]
人源脐带间充质干细胞来源的纳米囊泡通过抑制NF-κB/NLRP3通路的has-let-7g-5p缓解急性肺损伤
Yilin Huang,Yan Zeng,Ailin Wu et al.
Yilin Huang et al.
Aim: Acute lung injury (ALI), marked by vigorous inflammatory reactions and elevated incidence, is a grave clinical issue for which efficacious pharmaceutical interventions are still lacking. This research delves into the anti-inflammatory ...
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) as a novel topical immunomodulatory therapy for psoriasis: bridging the therapeutic gap in moderate disease [0.03%]
间充质基质细胞源外泌体(MSC-EVs)作为治疗中度银屑病的新型免疫调节药物：弥合治疗差距的新希望
Thong Teck Tan,Kok Hian Tan,Sai Kiang Lim
Thong Teck Tan
Psoriasis is a chronic, immune-mediated inflammatory disease that affects approximately 2%-3% of the global population, and remains a major dermatologic and psychosocial burden. Despite advances in biologics targeting interleukin 17 (IL-17)...
Comparison of methods for isolation of extracellular vesicles from bronchoalveolar lavage fluid [0.03%]
比较从支气管肺泡灌洗液中分离外泌体的方法
Mark E Fraser,Radha Patel,Taylor Shinabery et al.
Mark E Fraser et al.
Aim: Extracellular vesicles (EVs) have been described and isolated from a variety of biological samples, including bronchoalveolar lavage (BAL). While EVs have been isolated from BAL by various methods, there has not been a comparative stud...
The regulatory landscape for extracellular vesicle therapies: Australian context and future directions [0.03%]
澳大利亚外泌体疗法的监管格局及未来方向
Christopher Rudge,Reeve McClelland,Wojciech Chrzanowski et al.
Christopher Rudge et al.
Extracellular vesicles (EVs) are emerging as promising tools for regenerative medicine and drug delivery, offering unique therapeutic advantages. However, their clinical translation - in Australia and globally - faces persistent challenges....
Impact of flow cytometry-based sorting on microRNA signature of extracellular vesicles derived from mesenchymal stromal cells: a proof-of-concept study [0.03%]
流式细胞仪分选对间充质基质细胞衍生的外泌体中microRNA特征的影响：概念验证研究
Enrico Ragni,Monica Romanò,Michela Maria Taiana et al.
Enrico Ragni et al.
Aim: This proof-of-concept study aimed to evaluate the impact of fluorescence-based sorting on the microRNA (miRNA) molecular profile of extracellular vesicles (EVs) derived from adipose-derived mesenchymal stromal cells (ASCs) (ASC-EVs), w...
Multiorgan repair by MSC-derived extracellular vesicles in hepatorenal syndrome through necroptosis alleviation, immune reprogramming and fibrosis resolution [0.03%]
通过减轻坏死性凋亡、重编程免疫和解决纤维化治疗肝肾综合症中的多器官修复的间充质干细胞来源的外泌体
Kai-Chao Zhang,Shi-Han Mu,Run-Fang Song et al.
Kai-Chao Zhang et al.
Aim: To investigate the therapeutic potential and underlying mechanism of mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) in treating hepatorenal syndrome (HRS), a condition lacking therapies for multi-organ damage. Met...
Pomegranate-derived nanovesicles as therapeutic agents for acute pancreatitis in a murine model: anti-inflammatory, antioxidant, and endocrine-protective properties [0.03%]
基于番石榴的纳米囊泡作为急性胰腺炎的小鼠模型治疗剂：抗炎，抗氧化和内分泌保护特性
Isabel Torres-Cuevas,Christian M Sánchez-López,Antonio Marcilla et al.
Isabel Torres-Cuevas et al.
Aim: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas lacking specific therapy and frequently complicated by oxidative stress (OS) and long-term endocrine dysfunction, including pancreatogenic diabetes. Pomegranate-derive...
Circulating extracellular vesicle DNA (EV-DNA) and cell-free DNA in ovarian cancer: pathological relevance and diagnostic applications [0.03%]
外泌体DNA(EV-DNA)和游离DNA在卵巢癌中的病理意义及诊断应用
Dominic Guanzon,Rakesh Sankar,Pragati Lodha et al.
Dominic Guanzon et al.
Ovarian cancer is one of the leading causes of gynecologic cancer-related mortality in women. However, a significant proportion of ovarian cancer cases are only detected at an advanced stage (III or IV) and are complicated to treat because ...