Toxoplasma gondii infection induces extracellular vesicle miRNAs in synaptic plasticity and neural mechanisms [0.03%]
弓形虫感染通过细胞间微小核糖核酸在突触可塑性及神经机制中诱导释放外泌体
Poppy Cairney,Elton Rosas de Vasconcelos,Glenn A McConkey
Poppy Cairney
Aim: This study investigates the change in profiles of miRNAs in extracellular vesicles released during Toxoplasma gondii (T. gondii) infection. T. gondii has been implicated in host behavioural modifications and neuroinflammatory responses...
Lina Zhu,Kailu Guo,Xi Liu et al.
Lina Zhu et al.
A recent study on Cell Reports Medicine by Wang et al. introduces a hybrid exosome platform - selenized neural stem cell-derived exosomes (SeNExo) - that couples the biological functionality of neural stem cell exosomes with the antioxidant...
Astragalus polysaccharide promotes latent HIV-1 reactivation via exosome-mediated modulation of the PI3K/AKT/NF-κB axis [0.03%]
黄芪多糖通过外泌体介导的PI3K / AKT / NF-κB轴调节促进潜伏HIV-1再激活
Fang Xu,Shumin Luo,Pengpeng Lu et al.
Fang Xu et al.
Aim: Reactivating the human immunodeficiency virus type 1 (HIV-1) reservoir is one of the key avenues toward a functional cure for acquired immunodeficiency syndrome (AIDS). However, clinically effective and safe latency-reversing agents re...
Extracellular vesicle therapeutics in Alzheimer's disease: mechanisms, progress, and prospects [0.03%]
阿尔茨海默病的细胞外囊泡治疗：机制、进展和前景
Yiduo Fang,Xiaotong Hao,Bo Fang
Yiduo Fang
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide, characterized by progressive cognitive decline and a current lack of effective curative treatments. In recent years, extracellular vesicle (EV) therapies h...
Rethinking delivery routes: oral administration of plant-derived exosome-like nanovesicles reduces the toxicity of intravenous injection [0.03%]
重新考虑给药途径：植物源外泌体类似纳米囊泡的口服给药可降低静脉注射毒性
Li Chen,Bo Xiao
Li Chen
Plant-derived exosome-like nanovesicles (PELNs), as an emerging "green" nanoplatform, exhibit broad pharmacological activities, low immunogenicity, and inherent advantages as natural drug carriers. They show great potential in the pharmaceu...
Selective DNA encapsulation in extracellular vesicles of Saccharomyces cerevisiae [0.03%]
模式酵母细胞外囊泡的DNA选择性包封机制研究
Ana Perea-Martínez,Miguel Mejías-Ortiz,Pilar Morales et al.
Ana Perea-Martínez et al.
Aim: Extracellular vesicles (EVs) are emerging mediators of intercellular communication capable of transporting nucleic acids, including plasmid and genomic DNA. This study aimed to investigate the presence, enrichment, and protection of di...
Advanced small extracellular vesicles delivery systems for in situ tissue engineering [0.03%]
先进的小型细胞外囊泡原位组织工程递送系统
Yike Gao,Jingyi Sang,Zhuo Wan et al.
Yike Gao et al.
In situ tissue engineering, which activates the body's innate regenerative capacity, has demonstrated superior clinical translation potential than traditional ex situ approaches. Small extracellular vesicles (sEVs), as natural nanovesicles,...
Extracellular vesicles derived from TNF-α-preconditioned mesenchymal stem cells mitigate inflammatory retinal injury [0.03%]
肿瘤坏死因子α诱导的间充质干细胞来源的细胞外囊泡减轻视网膜炎症损伤
Zhuxin Jia,Fuxiao Luan,Jingyi Shi et al.
Zhuxin Jia et al.
Aim: To evaluate the therapeutic efficacy and mechanisms of tumor necrosis factor-alpha (TNF-α) preconditioned mesenchymal stem cells (MSCs)-derived small extracellular vesicles (hereafter abbreviated as T-sEV), along with the control smal...
80 years of extracellular vesicles: from discovery to clinical translation [0.03%]
外泌体研究80年：从发现到临床转化
Qiang Li,Yinan Ding,Yejiao Shi et al.
Qiang Li et al.
Extracellular vesicles (EVs) are heterogeneous, lipid bilayer-enclosed vesicles secreted by cells. Research on EVs dates back to the 1940s, and the term "exosomes" - a major subtype of EVs - was coined in 1981 to describe small membrane ves...
Improvement of small extracellular vesicle isolation from mouse model blood [0.03%]
从小鼠模型血液中改进分离小型细胞外囊泡的方法
Gloria Venturini,Antonella Ferrante,Nazzareno Di Carlo et al.
Gloria Venturini et al.
Aim: Small extracellular vesicles (sEVs) are membrane-bound nanoparticles secreted by virtually all cell types that have emerged as promising sources of protein biomarkers for a wide range of diseases, including central nervous system disor...