Multiorgan repair by MSC-derived extracellular vesicles in hepatorenal syndrome through necroptosis alleviation, immune reprogramming and fibrosis resolution [0.03%]
通过减轻坏死性凋亡、重编程免疫和解决纤维化治疗肝肾综合症中的多器官修复的间充质干细胞来源的外泌体
Kai-Chao Zhang,Shi-Han Mu,Run-Fang Song et al.
Kai-Chao Zhang et al.
Aim: To investigate the therapeutic potential and underlying mechanism of mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) in treating hepatorenal syndrome (HRS), a condition lacking therapies for multi-organ damage. Met...
Pomegranate-derived nanovesicles as therapeutic agents for acute pancreatitis in a murine model: anti-inflammatory, antioxidant, and endocrine-protective properties [0.03%]
基于番石榴的纳米囊泡作为急性胰腺炎的小鼠模型治疗剂：抗炎，抗氧化和内分泌保护特性
Isabel Torres-Cuevas,Christian M Sánchez-López,Antonio Marcilla et al.
Isabel Torres-Cuevas et al.
Aim: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas lacking specific therapy and frequently complicated by oxidative stress (OS) and long-term endocrine dysfunction, including pancreatogenic diabetes. Pomegranate-derive...
Circulating extracellular vesicle DNA (EV-DNA) and cell-free DNA in ovarian cancer: pathological relevance and diagnostic applications [0.03%]
外泌体DNA(EV-DNA)和游离DNA在卵巢癌中的病理意义及诊断应用
Dominic Guanzon,Rakesh Sankar,Pragati Lodha et al.
Dominic Guanzon et al.
Ovarian cancer is one of the leading causes of gynecologic cancer-related mortality in women. However, a significant proportion of ovarian cancer cases are only detected at an advanced stage (III or IV) and are complicated to treat because ...
Proteomic analysis of equine amniotic mesenchymal stromal cells and their extracellular vesicles: comparing their regenerative properties [0.03%]
马胎盘间充质干细胞及其外泌体的蛋白质组分析：比较其再生特性
Giulia Gaspari,Alessio Soggiu,Paola Gagni et al.
Giulia Gaspari et al.
Aim: To compare specific functional features of equine amniotic mesenchymal cells (eAMCs) and their extracellular vesicles (EVs) through proteomic analysis. Methods: eAMCs were obtained by enzymatic digestion and their EVs were isolated by ...
Chronic in utero oxycodone exposure alters placental small EV proteome and fetal cardiomyopathy-linked pathways [0.03%]
慢性子宫内奥施康定暴露改变胎盘小EV蛋白组和胎儿心肌病相关途径
Amin Foroughi-Nezhad,Dalia Moore,Victoria L Schaal et al.
Amin Foroughi-Nezhad et al.
Aim: The rising prevalence of opioid use during pregnancy poses serious public health concerns. The placenta is a critical organ during gestation, and opioid exposure can disrupt its function and fetal development. However, the molecular me...
Jingsong Liu,Xuqiang Gong,Yuanliang Sun et al.
Jingsong Liu et al.
Spinal cord injury (SCI) is a highly disabling disorder of the central nervous system for which no curative therapy is currently available. In recent years, extracellular vesicles - particularly exosomes - have been investigated as cell-fre...
Priming strategies to enhance the therapeutic efficacy of mesenchymal stromal/stem cell-derived vesicles in regenerative medicine [0.03%]
预处理策略增强间充质基质/干细胞衍生物囊泡在再生医学中疗效的研究进展
Vitale Miceli
Vitale Miceli
Mesenchymal stromal/stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising acellular therapeutics in regenerative medicine, offering a safer and more controllable alternative to whole-cell therapies. Their therapeutic ...
Extracellular vesicles as modulators of cancer metabolism and microenvironment [0.03%]
细胞外囊泡在癌症代谢和微环境调节中的作用
Veronica Feltri,Alessio Sanfilippo,Roberta Tasso et al.
Veronica Feltri et al.
The existence of small vesicles released by cells into the extracellular space was first documented over 40 years ago. These nanoparticles, now recognized as extracellular vesicles (EVs), were originally defined as "cellular dust" reflectin...
Vesicle-like nanoparticles extracted from Pueraria lobata decoction alleviate colitis by modulating the intestinal microbiota [0.03%]
从槐花豆煎剂中提取的类似囊泡的纳米颗粒通过调节肠道微生物群来缓解结肠炎
Cai-Xiao Liu,Yi-Juan Han,Na Zhao et al.
Cai-Xiao Liu et al.
Aim: This study aimed to investigate whether vesicle-like nanoparticles derived from the GeGen decoction (GGD-PDVLNs) represent a key bioactive component responsible for its anti-colitis effects and to elucidate their underlying mechanisms,...
Quantitative proteomic and functional comparison of extracellular vesicles from multiple adipose tissue mesenchymal stem cell donors [0.03%]
来自多个脂肪组织间充质干细胞供者的细胞外囊泡的定量蛋白质组学和功能比较分析
Kyong-Su Park,Dae Hyun Ha,Jun Ho Lee et al.
Kyong-Su Park et al.
Aim: Extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs), known as MSC-EVs, have gained attention as potential treatments owing to their immunomodulatory functions. Despite growing clinical interest, donor-to-donor incons...