Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design [0.03%]
基于细胞外囊泡的药物载体的内体逃逸机制及其对脂质纳米颗粒设计的启示
Lasse Hagedorn,David C Jürgens,Olivia M Merkel et al.
Lasse Hagedorn et al.
The rise of biologics and RNA-based therapies challenges the limitations of traditional drug treatments. However, these potent new classes of therapeutics require effective delivery systems to reach their full potential. Lipid nanoparticles...
Transfer of miR-100 and miR-125b increases 3D growth and invasiveness in recipient cancer cells [0.03%]
miR-100和miR-125b的转移增加接受者的癌细胞在三维空间中的生长能力和侵袭性
Hannah M Nelson,Shimian Qu,Liyu Huang et al.
Hannah M Nelson et al.
Aim: Extracellular communication via the transfer of vesicles and nanoparticles is now recognized to play an important role in tumor microenvironment interactions. Cancer cells upregulate and secrete abundant levels of mi...
Transcriptomic analysis of plasma-derived small extracellular vesicles reveals the pathological characteristics of normal tension glaucoma [0.03%]
基于血浆衍生的小细胞外囊泡的转录组分析揭示了正常眼压性青光眼的病理特征
Sheng-Lan Xu,Jun-Hua Li,Wen-Meng Zhang et al.
Sheng-Lan Xu et al.
Aim: Normal tension glaucoma (NTG) is a common optic neuropathy that can be challenging to diagnose due to the intraocular pressure remaining within the normal range. Early diagnosis and intervention are crucial for the e...
Flow cytometry for extracellular vesicle characterization in COVID-19 and post-acute sequelae of SARS-CoV-2 infection [0.03%]
用于表征COVID-19和SARS-CoV-2感染后急性期症候群的细胞外囊泡的流式细胞术
Marialaura Fanelli,Vita Petrone,Rossella Chirico et al.
Marialaura Fanelli et al.
Infection with SARS-CoV-2, the virus responsible for COVID-19 diseases, can impact different tissues and induce significant cellular alterations. The production of extracellular vesicles (EVs), which are physiologically involved in cell com...
Hitting the target: cell signaling pathways modulation by extracellular vesicles [0.03%]
靶向治疗：细胞信号通路的外泌体调节作用
Giada Cerrotti,Sandra Buratta,Raffaella Latella et al.
Giada Cerrotti et al.
Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released outside the cell. EVs have drawn attention not only for their role in cell waste disposal, but also as additional tools for cell-to-cell communication. Their com...
Extracellular vesicles in tumor-adipose tissue crosstalk: key drivers and therapeutic targets in cancer cachexia [0.03%]
肿瘤-脂肪组织交叉对话的细胞外囊泡：癌症恶病质的关键驱动因素和治疗靶点
Cátia C Ramos,José Pires,Esperanza Gonzalez et al.
Cátia C Ramos et al.
Cancer cachexia is a complex metabolic syndrome characterized by unintentional loss of skeletal muscle and body fat. This syndrome is frequently associated with different types of cancer and negatively affects the prognosis and outcome of t...
Assessment of NanoString technology as a tool for profiling circulating miRNA in maternal blood during pregnancy [0.03%]
NanoString技术在妊娠期间检测母体血液循环miRNA谱型中的应用评估研究
Petra Adamova,Andrew K Powell,Iain M Dykes
Petra Adamova
Aim: Circulating maternal MicroRNA (miRNA) is a promising source of biomarkers for antenatal diagnostics. NanoString nCounter is a popular global screening tool due to its simplicity and ease of use, but there is a lack o...
Role of probiotic extracellular vesicles in inter-kingdom communication and current technical limitations in advancing their therapeutic utility [0.03%]
益生菌细胞外囊泡在界间交流中的作用及其作为治疗药物的技术局限性
Rahul Sanwlani,Kyle Bramich,Suresh Mathivanan
Rahul Sanwlani
Diverse functions of probiotic extracellular vesicles (EVs) have been extensively studied over the past decade, proposing their role in inter-kingdom communication. Studies have explored their therapeutic role in pathophysiological processe...
Harnessing crosstalk between extracellular vesicles and viruses for disease diagnostics and therapeutics [0.03%]
利用细胞外囊泡和病毒之间的串扰进行疾病诊断和治疗
Xinxi Zhu,Xiuhui Lin,Liang Hu et al.
Xinxi Zhu et al.
Extracellular vesicles (EVs) are increasingly acknowledged as important mediators of intercellular communication, closely related to the occurrence and development of a variety of diseases. Numerous studies have demonstrated that EVs play a...
Substrate stiffness modulates extracellular vesicles' release in a triple-negative breast cancer model [0.03%]
基质刚度通过体外模型调节三阴性乳腺癌细胞来源的胞外囊泡的释放大小及作用
Beatrice Senigagliesi,Otmar Geiss,Stefano Valente et al.
Beatrice Senigagliesi et al.
Aim: The microenvironment effect on the tumoral-derived Extracellular Vesicle release, which is of significant interest for biomedical applications, still represents a rather unexplored field. The aim of the present work ...