Yan Zhen,Harald Stenmark
Yan Zhen
Cytokines are released by cells in response to infections and tissue damage. A recent paper by Jiao et al. demonstrates that circulating monocytes release the cytokines tumor necrosis factor and Interleukin-6 encapsulated in large extracell...
Disease-specific signatures of circulating extracellular vesicles detected by the surface plasmon resonance imaging: a pilot study [0.03%]
基于表面等离子共振成像技术的循环细胞外囊泡疾病特异性标志物筛选及验证的初步研究
Tatsuki Shibuta,Yukichi Takada,Shiori Nishinosono et al.
Tatsuki Shibuta et al.
Aim: Cells in the human body release extracellular vesicles (EVs) into fluids, such as plasma, urine, and cerebrospinal fluid. EVs express tetraspanin family proteins (e.g., CD63, CD9, and CD81) and cell-specific antigens on their surface a...
The times they are AI-changing: AI-powered advances in the application of extracellular vesicles to liquid biopsy in breast cancer [0.03%]
时代在AI下正发生变革：人工智能驱动的外泌体液体活检技术在乳腺癌中的应用进展
Vanesa García-Barberán,María Elena Gómez Del Pulgar,Heidy M Guamán et al.
Vanesa García-Barberán et al.
Artificial intelligence (AI) is revolutionizing scientific research by facilitating a paradigm shift in data analysis and discovery. This transformation is characterized by a fundamental change in scientific methods and concepts due to AI's...
A milestone for the therapeutic EV field: FDA approves Ryoncil, an allogeneic bone marrow-derived mesenchymal stromal cell therapy [0.03%]
治疗性EV领域的里程碑：FDA批准Ryoncil（同种异体骨髓源间充质基质细胞疗法）
Bernd Giebel
Bernd Giebel
Small extracellular vesicles (sEVs) derived from mesenchymal stromal cells (MSCs) hold substantial promise for therapeutic applications, including immune modulation and tissue regeneration. However, challenges such as batch-to-batch variabi...
Lexie Shannon Holliday,John K Neubert,Xianrui Yang
Lexie Shannon Holliday
The signaling gas hydrogen sulfide (H2S) has recently been implicated in the regulation of bone remodeling and the maintenance of periodontal health. Exploring the underlying mechanisms for this regulation holds promise for the development ...
Unraveling the role of amphisomes in mast cell secretory granule fusion and exosome release [0.03%]
揭秘变形溶酶体在肥大细胞分泌小泡融合及外泌体释放中的作用
Irene Tsilioni
Irene Tsilioni
Mast cells (MCs) play a crucial role in immune responses by storing and releasing inflammatory mediators from secretory granules (SGs). The biogenesis, maturation, and fusion of these granules with the plasma membrane regulate inflammation,...
Md Mofizur Rahman,Lixue Wang,Yundi Chen et al.
Md Mofizur Rahman et al.
Aim: A PCR- and sequencing-free mutation detection assay facilitates cancer diagnosis and reduces over-reliance on specialized equipment. This benefit was highlighted during the pandemic when high demand for viral nucleic acid testing often...
IFNγ preconditioning improves neuroprotection of MSC-derived vesicles on injured retinal ganglion cells by suppressing microglia activation via miRNA-dependent ribosome activity [0.03%]
干扰素γ预处理通过抑制小胶质细胞活化改善间充质干细胞衍生物囊泡对损伤视网膜神经节细胞的神经保护作用：一种miRNA依赖型起始因子机制
Tianjing You,Yuanxing Yang,Luodan A et al.
Tianjing You et al.
Aim: Microglial activation plays a pivotal role in the pathogenesis of retinal ganglion cell (RGC) degeneration resulting from optic nerve crush (ONC). Small extracellular vesicles (sEVs) secreted by mesenchymal stem cells (MSCs) have the p...
Extracellular vesicle-mediated chemoresistance in breast cancer: focus on miRNA cargo [0.03%]
乳腺癌的细胞外囊泡介导的化疗耐药性：关注miRNA货物
Maria Chiara Ciferri,Roberta Tasso
Maria Chiara Ciferri
The role of extracellular vesicles (EVs) in mediating chemoresistance has gained significant attention due to their ability to transfer bioactive molecules between drug-resistant and drug-sensitive cells. In particular, they have been demon...
Extracellular vesicles and miRNA-based therapies in triple-negative breast cancer: advances and clinical perspectives [0.03%]
三阴性乳腺癌的细胞外囊泡和miRNA疗法：进展与临床应用展望
Caroline Patini de Rezende,Débora de Lima Alves,Luiz Gustavo de Almeida Chuffa et al.
Caroline Patini de Rezende et al.
Triple-negative breast cancer (TNBC) is one of the most aggressive and challenging subtypes for treatment, due to the lack of hormone receptors and the human epidermal growth factor receptor 2 (HER2) protein. The identification of new molec...