Li Zhang,Jun Liu,Yuxuan Xiong et al.
Li Zhang et al.
Photocatalysis has been recognized as a promising approach in cancer theranostics over the past years. To enhance therapeutic outcomes and overcome current limitations, significant attention has been directed toward the development of multi...
Enhancing Bidirectional Sulfur Conversion Through p-d Orbital Hybridization via Vacancy Engineering [0.03%]
通过空位工程利用p-d轨道杂化增强硫的双向转化
Yan Chen,Dan Li,Yufang Chen et al.
Yan Chen et al.
Lithium-sulfur batteries (LSBs) have garnered significant concern as materials with high energy density for energy storage. Nevertheless, their severe shuttle effect and delayed redox kinetics limit their practical application. Herein, a st...
Ferrimagnetic Vortex Nanorings Facilitate Efficient and Safe Deep-Brain Magnetothermal Stimulation in Freely Moving Mice [0.03%]
铁性涡旋纳米环在自由活动小鼠深部磁热刺激中的高效和安全促进作用研究
Galong Li,Xin Qiao,Yu Zhao et al.
Galong Li et al.
Magnetothermal neuromodulation is a minimally invasive, deep-brain accessible, and tether-free technique. The precisely timed activation of thermosensitive ion channels, such as TRPV1, with local heat generated using magnetic nanoparticles ...
Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis: Modulating Crotonylation in Ulcerative Colitis [0.03%]
溃疡性结肠炎中调控赖氨酸柠檬酸修饰维持线粒体稳态：溃疡性结肠炎中调控赖氨酸柠檬酸修饰抗氧化能力
Tongtong Liu,Binyan Lin,Ying Zhang et al.
Tongtong Liu et al.
Ulcerative colitis (UC) is a chronic and persistent clinical condition that is challenging to cure. Lysine crotonylation (KCr), a recently discovered post-translational modification (PTM), alters protein structure, stability, localization a...
A Groundbreaking Electric Field-Induced Cascade Gas Therapy Against Large Volume Solid Tumor Through Electro-Stress Storm [0.03%]
一种基于电场诱导级联气体治疗大规模实体肿瘤的全新疗法——电应力风暴疗法
Gui Chen,Wenjia Zhang,Manchun Wang et al.
Gui Chen et al.
Gas therapy has been limited in its application as a robust standalone antitumor strategy due to the restricted gas production and cytotoxicity. To address this challenge, we employed electrotoxic PtRu composite metal nano-berries (PR) load...
A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid Tumors [0.03%]
一种用于实体肿瘤时空靶向治疗的生物正交可编程细菌递送系统
Yu-Jia Wang,Wen-Jie Jiang,Hua-Jun Zhao et al.
Yu-Jia Wang et al.
Rapid advances in synthetic biology are driving the development of microbes as therapeutic agents. While the immunosuppressive tumor microenvironment creates a favorable niche for the systematic delivery of bacteria and therapeutic payloads...
An Anisotropic and Stable-Conductance Patch for Mechanical-Electrical Coupling With Infarcted Myocardium [0.03%]
一种各向异性且传导稳定的贴片用于心肌梗死组织的机电耦合
Yimeng Li,Yuchen Miao,Leqian Wei et al.
Yimeng Li et al.
Polymeric conductive patches have conventionally been employed to facilitate the repair of infarcted myocardium by enhancing myocardial electrical conduction and providing mechanical support. However, it remains a challenge to restore the e...
Target Binding of Black Phosphorus Nanomaterial to Polo-Like Kinase 1 for Cancer Chemotherapy: A Mutual Selection of Nanomaterial and Protein [0.03%]
以黑磷纳米材料靶向结合于细胞极光激酶为机制的癌症化疗研究：纳米材料与蛋白质相互选择效应
Fangfang Liu,Zhong-Da Li,Yanqiao Zeng et al.
Fangfang Liu et al.
The intrinsic properties of black phosphorus (BP) nanomaterials (NMs) enable them for targeted binding to polo-like kinase 1 (PLK1), thus inhibiting its kinase activity. However, the mechanism and targeted binding sites underlying this inte...
Synergistic Effects of MHD Dynamics and Oxygen Vacancies on Electrode Polarization in Photoelectrocatalysis CO2 Reduction Systems [0.03%]
磁流体动力学效应和氧空位对光催化二氧化碳还原系统电极极化协同作用的影响研究
Lei Zhao,Feng Xiao,Xianghui Zeng et al.
Lei Zhao et al.
Photoelectrocatalysis reduction of CO2 into products such as CO and CH4 is an effective strategy for improving carbon utilization and advancing the development of renewable energy. Improving the catalytic efficiency by regulating the polari...
Personalized Cancer Immunotherapy Boosted by cGAS-STING-Targeted Nanovaccines in Combination With Nutrient Modulation [0.03%]
用于个性化癌症免疫治疗的cGAS-STING靶向纳米疫苗结合营养调节研究
Wenping Huang,Guoliang Cao,Mixiao Tan et al.
Wenping Huang et al.
Cyclic dinucleotides, which act as agonists for the stimulator of interferon genes (STING), are pivotal in stimulating both adaptive and innate immune reactions for advancing cancer immunotherapy. However, their therapeutic potential is ham...