M2 Macrophage-Mimetic and ROS-Sensitive Hybrid Nanoplatform for Targeted Alleviation of Rheumatoid Arthritis [0.03%]
一种模拟M2型巨噬细胞的ROS响应型纳米药物递送系统治疗类风湿关节炎
Yi Xiao,Shiyu Meng,Zhuang Tang et al.
Yi Xiao et al.
Rheumatoid arthritis (RA) constitutes the most prevalent inflammatory arthropathy globally, which is typically marked by synovitis and deteriorating joint damage. Regrettably, RA remains incurable owing to insufficient therapeutic response ...
Hepatic Mechanisms and Therapeutic Target Underpinning Hypercoagulation in Obesity: Insights From Genetic and Transcriptomic Analyses [0.03%]
肥胖相关高凝血的肝脏机制和治疗靶点：来自遗传学和转录组学分析的启示
Shumin Li,Gengchen Feng,Xin Huang et al.
Shumin Li et al.
Obesity predisposes individuals to hypercoagulation, a key factor in life-threatening complications like stroke and cardiovascular disease. While clotting factors are primarily secreted by the liver, the mechanisms linking obesity to hyperc...
Zero-Valent Ruthenium-Anchored Nanozymes Remodel Tumor Microenvironment for Malignant Tumor Treatment in Combination With αPD-L1 Immunotherapy [0.03%]
结合αPD-L1免疫疗法利用零价锚定纳米酶重塑肿瘤微环境以治疗恶性肿瘤
Xihang Ren,Zhaoxu Meng,Liyuan Guan et al.
Xihang Ren et al.
The complex tumor microenvironment (TME) includes high concentrations of hydrogen peroxide, high expression of reduced glutathione (GSH), hypoxia, and the resulting immunosuppression from the combination of these features, posing major chal...
Quadruplex Bioactive FAND for Treating Acute Liver Failure Induced by Acetaminophen or Hepatectomy [0.03%]
用于治疗由乙酰氨基酚或肝切除引起的急性肝衰竭的四联活性FAND疗法
Meng Sun,Fang Fang,Juan Liu et al.
Meng Sun et al.
Acute liver failure (ALF), characterized by severe hepatocyte necrosis with a high mortality rate, remains a major global health challenge. However, there are currently no effective drug options for the clinical treatment of ALF. Herein, in...
A High-Efficiency Yet Sustainable Fresh-Keeping Strategy Inspired by Calyx of Physalis peruviana [0.03%]
仿番木瓜萼片高效低耗保鲜策略
Yue Zhao,Chengbang Lu,Xiaopeng Bai et al.
Yue Zhao et al.
To address the dual challenges of foodborne illness and plastic pollution, we present a sprayable, calyx-inspired food wrap engineered for safety and sustainability. Utilizing handheld electrospraying, zeolite-doped polycaprolactone forms a...
Qiang Ma,Hai-Peng Wang,Yu-Meng Jiang et al.
Qiang Ma et al.
Spontaneous calcium (Ca2+) waves play a critical role as internal stimuli in the early developing auditory system before the onset of sensory experiences. However, neither the spatiotemporal control of spontaneous Ca2+ waves nor their impac...
Customizing 3D Hierarchically Macroporous Covalent Organic Framework Superstructures for Improved Biosensing Interface in Highly-Sensitive Electrochemical Biosensors [0.03%]
用于高性能电化学生物传感器的分级三维共价有机框架超结构及其优异的生物传感界面性能
Wenbo Wei,Sheng-Hua Zhou,Dong-Dong Ma et al.
Wenbo Wei et al.
The construction of an optimized biosensing interface is critically important for electrochemical biosensing. Herein, we achieve the controllable construction of macroporous covalent organic framework (COF) nanostructures through a template...
Elimination of Fusobacterium nucleatum With Biomimetic Nanoparticles to Reverse Tumor Immunosuppression and Enhance Colorectal Cancer Therapy [0.03%]
利用仿生纳米颗粒清除核梭杆菌以逆转肿瘤免疫抑制并增强结直肠癌治疗效力
Mengting Zhou,Jiahao Du,Cheng Li et al.
Mengting Zhou et al.
Tumor-associated microbes like Fusobacterium nucleatum (F. nucleatum) critically contribute to immunosuppression and hinder cancer therapy. To overcome this challenge, we developed a microbe-targeted immune reprogramming strategy utilizing ...
An Ocular Surface-Targeting Nucleic Acid Hydrogel for Efficient Dry Eye Disease Treatment [0.03%]
一种有效治疗干眼病的核酸水凝胶眼球表面递送系统
Yuhe Liu,Zimeng Zhai,Yangyang Huang et al.
Yuhe Liu et al.
Dry eye disease (DED) is a prevalent disorder affecting millions worldwide, fueled by both the aging population and extensive use of electronic devices. Yet, current treatments for moderate-to-severe DED fail to fully meet the clinical need...
Antibacterial Hydrogel Dressing With Ca2+-Dependent Hyaluronidase Responsiveness for Accelerating Wound Healing via On-Demand Release of AIE Photosensitizers [0.03%]
一种基于Ca2+响应的透明质酸酶水凝胶抗菌敷料，用于伤口按需递送聚集诱导发光光敏剂治疗加速创面修复功能
Rongwei Cui,Hao Yang,Miaomiao Kang et al.
Rongwei Cui et al.
Reactive oxygen species (ROS)-assisted photodynamic antibiosis emerges as an effective non-antibiotic way to eradicate bacteria in infected wounds. To minimize the indiscriminate damage of excessive ROS to normal tissues, on-demand release ...