Cholesterol Metabolism Regulated Nanoliposome Ameliorates Chemo/Photothermal Therapy Reversing CD8+ T Cell Exhaustion [0.03%]
胆固醇代谢调节纳米脂质体改善化疗/光热疗逆转CD8+T细胞衰竭
Panpan Xue,Tingjie Bai,Huilan Zhuang et al.
Panpan Xue et al.
Stimulating the immunogenic cell death (ICD) by chemical and photothermal agents triggers antitumor immune responses to tumor treatments. However, the abnormal cholesterol accumulation in cancer cells promotes tumor survival and metastasis,...
Phase-Change Assembling Nanostructures Synergistically Potentiate Tumor Radiosensitivity by Reducing the Stemness of Cancer Stem-Like Cells [0.03%]
相变组装纳米结构通过减少癌干细胞样细胞的干性协同提高肿瘤放射敏感性
Yuanfang Chen,Xueyin Hu,Ze Hu et al.
Yuanfang Chen et al.
Cancer stem-like cells (CSCs) within deep tumors are a fundamental contributor to radiotherapy (RT) resistance due to their pronounced stemness resulting in unique unlimited self-renewal and differentiation capabilities. Alleviating hypoxic...
EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease [0.03%]
EGR1核凝集物可促进多囊肾病的肾囊肿发生发展
Chaoqun Ren,Zhaoxu Wu,Min Li et al.
Chaoqun Ren et al.
Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP-PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over...
Targeting MGAT4A-Mediated N-Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion [0.03%]
靶向MGAT4A介导的N-连接糖基化以抑制胶质母细胞瘤干细胞侵袭
Rui Niu,Meichen Liu,Qingshan Yang et al.
Rui Niu et al.
Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, ...
Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances [0.03%]
伤口愈合中抑制疤痕形成：机制、设计及近期进展
Yong Kang,Yiwen Yang,Bin Yao et al.
Yong Kang et al.
Scar inhibition plays a crucial role in wound healing, particularly in the prevention of excessive scar formation during skin repair. While scar formation is a natural part of the healing process, improper scarring can lead to functional im...
Zhixia Xu,Shuo Bao,Massimo Moccia et al.
Zhixia Xu et al.
Electromagnetic metasurfaces with suitably designed spatial modulations of surface impedance can guide surface waves similarly to volumetric dielectric waveguides. As a result, the transverse distribution of the fundamental mode is usually ...
Sunlight-Driven Fixation of CO2 to Cyclic Carbonates Using Carbon Dots as a Photothermal Catalyst [0.03%]
碳点作为光热催化剂驱动二氧化碳合成环状碳酸酯
Ruijia Wang,Hongda Guo,Tao Zhang et al.
Ruijia Wang et al.
Fixation of CO2 through photocatalytic cycloaddition with epoxides to synthesize cyclic carbonates is an important but challenging process. In this work, carbon dots (CDs) synthesized from gallic acid and polyethylenimine are used for the e...
One-Stone-Two-Birds Carrier-Free Nano-Cocktail Enables Synergistic Eradication of Cancer Cells/Stem Cells in Breast Cancer Treatment [0.03%]
“一石二鸟”无载体纳米鸡尾酒疗法协同根除乳腺癌细胞/干细胞
Tongyao Zhao,Yao Chen,Haimeng Yuan et al.
Tongyao Zhao et al.
Cancer stem cells (CSCs) are widely recognized as the culprits of chemoresistance, tumor metastasis, and relapse. Moreover, most chemotherapeutic drugs not only fail to eliminate CSCs effectively, but also induce the acquisition of stemness...
Plasma Activate Nitrogen for Efficient Ammonia Synthesis: Plasma Ammonia Synthesis [0.03%]
富含氮等离子体高效合成氨：等离子体氨合成技术研究进展
Yamei Zhang,Jianfei Yu,Haixia Wu et al.
Yamei Zhang et al.
Synthetic ammonia is of great significance to the development of industry and agriculture. At present, its manufacturing production is still dominated by century-old Haber-Bosch process, involving in huge amounts of energy consumptions and ...