Real-Time Feedback Strategically Regulates Optoelectronics for Customized Optogenetic Spinal Cord Regeneration [0.03%]
实时反馈调节光电子学以实现定制的光遗传脊髓再生
Kaishun Xia,Runze Hu,Xiaopeng Zhou et al.
Kaishun Xia et al.
Previous optogenetic bioelectronic systems have enabled a highly selective way of modulating neural populations by delivering a certain wavelength of light to engage with exogenously expressed light-sensitive proteins, which lay the foundat...
Ultrasmall Au10-12 Nanoclusters: A Novel Platform for 223Ra-Targeted Tumor α-Therapy [0.03%]
超小型Au10-12纳米簇：一种新的223Ra靶向肿瘤α治疗平台
Yifei Jiang,Huizhen Yang,Guoping Jia et al.
Yifei Jiang et al.
223Ra, a potent α-emitting radionuclide, is currently limited to treating bone metastases in clinical practice. This constraint stems from the lack of stable chelating agents capable of withstanding its high recoil energy and the five deca...
Flexible Multi-Mode Electrochromic Displays for Human Motion Monitoring and Pattern Display in Dark Environments [0.03%]
用于黑暗环境人体运动监测和图案显示的柔性多模电致变色显示器
Xue Chen,Qi Zhao,Li Wang et al.
Xue Chen et al.
Flexible electrochromic displays (ECDs) demonstrate low energy consumption, good readability, and high color contrast. However, their performance deteriorates in dark environments due to the reliance on environment light. Herein, we propose...
EnzRetro: Enzymatic Retrosynthetic Planning With Site-Specific Reaction Edits Based on Sequence Generative Architecture [0.03%]
基于序列生成架构的具有位点特异性反应编辑的酶促逆合成规划方法（EnzRetro）
Yahui Cao,Haoshu Chen,Tao Zhang et al.
Yahui Cao et al.
Enzymatic biosynthesis has become increasingly crucial in green chemistry and biosynthesis. However, current computational tools struggle to effectively integrate enzyme identification with pathway synthesis due to the specificity of enzyme...
Microengineering the Liver: Strategies for Constructing Functional Liver-on-a-Chip Devices [0.03%]
肝脏微工程：构建功能性芯片肝脏装置的策略
Jie Wang,Ziwei Liang,Jiapu Wang et al.
Jie Wang et al.
Reliable in vitro liver models are indispensable for researching liver diseases and developing medications. Present 2D/3D cell cultures and animal models inadequately replicate the intricacy of living systems and in vivo conditions, resulti...
Collaborative Optimization of Electromagnetic Interference Shielding, Adaptive Multi-Color, and Thermal Camouflage of Basalt Fibers by Temperature-Induced Gradient Structure Control [0.03%]
基于温度诱导梯度结构调控的玄武岩纤维电磁屏蔽、变色和温控隐身协同优化
Sijie Qiao,Zhicheng Shi,Annan He et al.
Sijie Qiao et al.
Basalt fiber fabric (BFF) has gained extensive application in industrial, military, and aerospace fields due to its lightweight nature, chemical inertness, and mechanical durability. However, the inherent surface inertness and electrical in...
Autologous Extracellular Matrix-Based Cell-Free Therapy for Tissue Regeneration Through Trem2+ Macrophages Mediated Angiogenesis [0.03%]
自体细胞外基质无细胞疗法通过Trem2+巨噬细胞介导的血管生成促进组织再生
Mengmeng Hou,Nini Shi,Yajie Guo et al.
Mengmeng Hou et al.
The extracellular matrix (ECM) is vital for tissue regeneration and remodeling by providing structural support and regulating cell behavior. Bioactive membranes derived from decellularized ECM show promising regenerative potential in many f...
Recent Advances in Conjugated Microporous Polymers for Photocatalysis: Mechanism, Synthesis and Applications [0.03%]
用于光催化的导电微孔聚合物最新进展：机制、合成及应用
Dun Zhou,Kongqing Zhang,Xiaobai Li et al.
Dun Zhou et al.
As the global energy crisis intensifies and environmental pollution continues to deteriorate, harnessing solar energy through photocatalytic processes is emerging as a leading strategy to meet energy needs and combat climate crisis. Natural...
Immunosuppressive Microenvironment Reprogramming by Synergistic Sonodynamic Therapy of Phthalocyanine-MOF Hybrids for Hepatocellular Carcinoma [0.03%]
协同声动力免疫治疗肝癌中的免疫抑制微环境重塑磷菁MOF杂化材料的研究
Han Wu,Lihui Gu,Jiahao Xu et al.
Han Wu et al.
Hepatocellular carcinoma (HCC) remains a critical global health challenge with limited treatment efficacy hindered by therapy resistance and hypoxia-induced immune suppression. Tumor heterogeneity and low immune cell reactivity often lead t...
One-Stone-Three-Birds Biomimetic Oral Targeting Delivery Strategy for On-Demand Controlled Drug Release and Intervertebral Disc Degeneration Therapy [0.03%]
一种一石三鸟的仿生口服靶向递送策略，用于按需控制药物释放和治疗椎间盘退变
Yifan Ding,Yixin Cai,Weizhen Pan et al.
Yifan Ding et al.
Intervertebral disc degeneration (IDD) is a multifactorial condition characterized by excessive inflammation, immune dysfunction, and metabolic disorders. Current therapeutic strategies primarily rely on local injection, a traumatic approac...