Ying Cai,Jiameng Chen,Yaping Li
Ying Cai
Micro Pattern-Based 3D Cell Culture Platform: An Overview of Technologies and Applications [0.03%]
基于微图案的三维细胞培养平台：技术与应用概述
Xinglong Zhu,Yi Li,Hulin Long et al.
Xinglong Zhu et al.
Three-dimensional (3D) multicellular models are considered ideal methods for bridging the gap between two-dimensional (2D) cell culture and animal models, which are widely used in organogenesis, disease models, drug development, and regener...
Surmounting Recalcitrant Airway Inflammatory Disorders With a Multi-Targeting Therapeutic Strategy by Tannic Acid-Modified CuInP2S6 Nanosheets [0.03%]
利用单宁酸改性CuInP2S6纳米片多靶点治疗策略对抗难治性气道炎症性疾病
Ming Liu,Changyi Xu,Renqiang Ma et al.
Ming Liu et al.
Recalcitrant airway inflammatory diseases have drawn significant attention due to their high incidence and substantial healthcare costs. Analysis of clinical samples from patients with chronic rhinosinusitis with nasal polyps (CRSwNP) revea...
Spherical Nucleic Acid Stabilized Cage Type Three-Dimensional Electrochemiluminescence Probe for Sensitive and Amplification-Free Diagnosis of Infectious Diseases [0.03%]
稳定的笼型三维电化学发光探针用于感染性疾病的灵敏且无需放大诊断
Yu Fu,Wenlu Song,Jinyan Lin et al.
Yu Fu et al.
Accurate nucleic acid-based pathogen diagnosis is critical for clinical treatment and epidemic control. However, present gold-standard testing methods based on nucleic acid amplification are limited by their time and labor-intensive nature....
RBFOX1 Dysfunction Unlocks APOE4-Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids [0.03%]
RBFOX1功能障碍解锁APOE4相关的小胶质细胞发生并加剧人脑类器官中的阿尔茨海默病病理学
Bowen Zhang,Changjie Shi,Jiayi Zhao et al.
Bowen Zhang et al.
Alzheimer's disease (AD) pathogenesis is strongly influenced by APOE4, though how cooperative genetic factors modulate this relationship remains unclear. While genomic studies have tentatively linked RBFOX1 to AD susceptibility, its functio...
Bacterial Biohybrids With Dual Magnet and Hypoxia Tropism for Ferroptosis Activation in Deep Tumor Regions [0.03%]
具有双重磁性和低氧趋性的细菌生物杂合体用于激活深部肿瘤区域的铁死亡
Sijie Shao,Huilan Zhuang,Tingjie Bai et al.
Sijie Shao et al.
Effectively delivering therapeutics to deep tumor regions is crucial for successful treatment but remains a formidable challenge. The severe hypoxia common in these areas can inhibit various therapeutic-induced cell death pathways, includin...
When Rare Is Not Small: Amyotrophic Lateral Sclerosis Initiatives and Therapy [0.03%]
当罕见不等于小众——渐冻症研究与治疗的全球行动
Yang Liu,Xue Xia,Yingfang Chen et al.
Yang Liu et al.
In the precision-medicine era, rare diseases must not be sidelined in translational infrastructure. The Mr. Cai Lei-led "Ice-Breaking Team" turns an amyotrophic lateral sclerosis patient community into a sustainable ecosystem, realigning ph...
Rumen Mycobiome Thiamine Metabolism Contributes to Subacute Rumen Acidosis Tolerance in Goats Through Enhancing Epithelial Cell Proliferation via IGFBP2/IGF1 Axis Activation [0.03%]
瘤胃真菌代谢组维生素B1代谢通过激活IGFBP2 / IGF1轴促进细胞增殖从而提高山羊对亚急性瘤胃酸中毒的耐受性研究
Jingyi Xu,Xiaodong Chen,Yi Ma et al.
Jingyi Xu et al.
Subacute rumen acidosis (SARA) is a critical metabolic disorder in dairy ruminants that threatens their milk production. However, the mechanisms by which rumen fungi influence the susceptibility and tolerance of ruminants to SARA remain unc...
Modification-Response Integrated Modules Driven Cyclization-Dependent Prodrug Self-Assembly for Reshaping Pro-Apoptotic Tumor Redox Homeostasis [0.03%]
用于重塑肿瘤促凋亡氧化还原稳态的药物递送体系促进前药自组装
Yixin Sun,Shiyi Zuo,Wenfeng Zang et al.
Yixin Sun et al.
Affected by the complexity and heterogeneity of the tumor redox microenvironment, chemotherapy often fails to achieve satisfactory clinical outcomes. Modular design of prodrug nanoassemblies presents tremendous potential in upgrading the th...
The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases [0.03%]
线粒体在围产期心脏发育和心血管疾病中的代谢作用
Minghao Li,Ruiyi Zhang,Xinyuan Li et al.
Minghao Li et al.
The heart, as the central organ of the circulatory system, undergoes distinct metabolic transitions from embryonic development through postnatal maturation. A key aspect of this transition is mitochondrial maturation, which is influenced by...