Hong Zhang,Yi Yang,Heng Li et al.
Hong Zhang et al.
The rapid and accurate identification of nucleic acids (NAs) is essential to early diagnosis and treatment of disease in healthcare. Paper-based analytical devices (PADs) offer a preferred alternative to laborious, expensive, and time-consu...
Photodynamic Biomimetic Nanoparticles Accelerate Tumor Vascular Normalization Initiation [0.03%]
光动力仿生纳米颗粒加速肿瘤血管正常化启动
Yufei Liu,Changheng Xie,Yanfeng Huang et al.
Yufei Liu et al.
The abnormal tumor vascular networks fuel the tumor growth and aggravate the tumor hypoxia. Although vascular normalization therapy (VNT) is clinically effective, the long period before vascular normalization window (VNW) initiation present...
Mechanistic Understanding of Nickel Catalyzed Urea Oxidation Reaction to Cyanate and Nitrite [0.03%]
镍催化尿素氧化反应生成氰酸盐和硝酸盐的机理研究
Kyu In Shim,Jiseon Kim,Miyeon Kim et al.
Kyu In Shim et al.
The urea oxidation reaction (UOR) is a promising alternative to the oxygen evolution reaction (OER) for sustainable hydrogen production due to its lower onset potential. However, the reasons behind this advantage remain unclear, with incons...
Sustained-Release Ulcer-Protective Microarray Patch With Dihydrocapsaicin for Diabetic Wound Regeneration [0.03%]
长效辣椒素衍生物治疗糖尿病创面溃疡微阵列贴剂
Yuxu Wu,Kan Jiang,Xiao Wen et al.
Yuxu Wu et al.
Diabetic foot ulcers (DFUs) present a persistent clinical challenge, posing a significant and ongoing threat to patient health. Current treatment strategies are failing to concurrently address the excessive oxidative stress and impaired ang...
Artificial Chlorella Biohybrids for Alleviation of Cartilage Degeneration in Osteoarthritis [0.03%]
人工藻类生物杂化技术缓解骨关节炎软骨退变
Yongyun Chang,Keyu Kong,Minghao Jin et al.
Yongyun Chang et al.
Osteoarthritis (OA), one of the most common chronic joint diseases, is characterised by cartilage imbalance and disruption of the cartilage extracellular matrix. In this study, we observed impaired mitophagy and glucose metabolism disorders...
Shiyong Li,Ye Wang,Guangyu Jia et al.
Shiyong Li et al.
The perivascular space (PVS) around cerebral arteries supports nutrient delivery and waste clearance, yet its transport mechanisms remain poorly defined. Here, we establish arterial PVS as a major solute transport route in the brain, exhibi...
Honggang Shen,Wenzhe Yi,Rongzhang Li et al.
Honggang Shen et al.
Optogenetics represents a promising frontier in precision cancer therapy by enabling spatiotemporal control over cellular behavior. However, its clinical application is limited by inefficient delivery of optogenetic components and poor tiss...
Optimization of Lithium-Mediated Nitrogen Reduction via Electrolyte Engineering [0.03%]
通过电解质工程优化锂介导的氮还原反应
Xiyang Cai,Kaixiang Wang,Ruilin Wang et al.
Xiyang Cai et al.
Ammonia serves as a fundamental precursor for nitrogen-based chemicals in both agriculture and industry, which is mainly produced by the Haber-Bosch process. Lithium-mediated nitrogen reduction (LiNR) has emerged as a promising alternative ...
Sustainable Plant-Based Electrodes for Electrocatalytic Conversion of Small Molecules: From Biomass to Functional Electrodes [0.03%]
基于植物的可持续电极用于小分子电催化转化：从生物质到功能电极
Ying Long,Zhijie Chen,Jiangzhou Xie et al.
Ying Long et al.
Electrocatalysis has emerged as a cornerstone in advancing energy conversion, storage, and the production of value-added chemicals. A pivotal determinant of electrocatalytic efficiency lies in the design of electrode materials, underscoring...
Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1-Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma [0.03%]
依托莫酸沉默SGO2抑制糖酵解与BRCA1介导的DNA损伤修复改善肺腺癌化疗敏感性
Xian Lin,Zhidan Hua,Chen Liu et al.
Xian Lin et al.
Aerobic glycolysis and DNA damage repair participate in modulating LUAD chemo sensitivity, while the connection between glycolysis and DNA repair is not fully discovered. Here, integrated multi-omics analyses recognized SGO2 as a glycolysis...