Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti-Inflammation in Diabetic Wounds [0.03%]
姜黄素包裹凝胶原诱导M1型巨噬细胞铁死亡的新抗炎机制促进糖尿病伤口修复
Shengnan Cui,Sheng Meng,Yong Liu et al.
Shengnan Cui et al.
Diabetic wounds are characterized by chronic inflammation, partly due to the persistent accumulation of pro-inflammatory M1 macrophages. Asiaticoside (AS), a triterpenoid extracted from Centella asiatica, has known anti-inflammatory effects...
Targeting NAT10 Inhibits Hepatocarcinogenesis via ac4C-Mediated SMAD3 mRNA Stability [0.03%]
靶向抑制NAT10通过ac4C介导的SMAD3 mRNA稳定性抑制肝细胞癌发生
Yigan Zhang,Yanbin Dong,Shuwen Chen et al.
Yigan Zhang et al.
Hepatocellular carcinoma (HCC) is characterized by high morbidity and mortality, with limited effective treatment options. N-acetyltransferase 10 (NAT10) is the only known acetyltransferase for mRNA ac4C modification and is recognized as a ...
Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice [0.03%]
咖啡酸通过与小鼠中的 annexin a5 蛋白共价作用强力调节衰老并缓解炎症和肺纤维化
Yinhua Zhu,Ying Zhang,Qianyu Zhang et al.
Yinhua Zhu et al.
The accumulation of senescent cells and their secretion of senescence-associated secretory phenotype (SASP) play important roles in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Small molecules, known as senolytics or senomorphic...
Qi Li,Haonan Xing,Abid Naeem et al.
Qi Li et al.
Messenger RNA (mRNA) therapeutics and vaccines have recently gained particular prominence following the COVID-19 epidemic. However, clinical translation of mRNAs is critically dependent on efficient and safe delivery in vivo. Currently, a p...
Global Stress Responses Identify the Functionally Divergent Regulators Required for Candida auris Commensalism and Pathogenicity [0.03%]
全局压力响应鉴定出克鲁斯念珠菌共生和致病所需的功能分歧调节因子
Chaoyue Xu,Wanxing Xu,Yushun Yuan et al.
Chaoyue Xu et al.
Given its global distribution and high transmissibility in the environment, Candida auris poses a serious threat to global public health. However, the underlying mechanisms of its adaptive strategies remain poorly understood. Here we deline...
Layout Optimization of the Six-Axis Industrial Robot Based on an Improved Whale Algorithm for Reducing Energy Consumption in Industry 5.0 [0.03%]
基于改进鲸鱼算法的六轴工业机器人布局优化减少5.0工业能耗问题研究
Kaiyue Cui,Yixiong Feng,Zhaoxi Hong et al.
Kaiyue Cui et al.
In the advent of Industry 5.0, the harmonious integration of human ingenuity and robotic precision in complex work environments is pivotal for sustainable industrial growth. The six-axis industrial robot, as an essential part of carrying ou...
Trash-to-Energy: Shedding Light on Plastic and Biomass Valorization Through Artificial Photosynthesis Towards Sustainability [0.03%]
人工光合作万物：塑料和生物质资源化利用的可持续发展之路
Ke Ming Lim,Valerine Khoo,Wee-Jun Ong
Ke Ming Lim
Solid waste remains a global crisis in which massive amount of solid waste is disposed of in landfills and the environment yearly, leading to detrimental environmental pollution and loss of resources. However, the current downcycling techno...
Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process [0.03%]
受骨愈合过程启发的骨膜类器官：仿生设计
Shuyue Hao,Fuxiao Wang,Jingtao Huang et al.
Shuyue Hao et al.
Large bone defects present major problems in plastic, maxillofacial, and orthopedic reconstructive surgery. With respect to osseous tissues, currently, autologous and allogeneic bone grafts are commonly used clinical treatments, but there a...
Nonporous Adaptive Crystals Based on Pillararene/Calixarene-Inspired Novel Macrocyclic Arenes [0.03%]
基于柱芳烃和冠醚的新型大环芳烃的非多孔自适应晶体
Susu Ren,Haitao Wang,Bowen Zha et al.
Susu Ren et al.
Nonporous adaptive crystals (NACs) represent a unique class of supramolecular macrocycle-based crystalline organic materials that have garnered significant attention in supramolecular chemistry and beyond over the past decade. Unlike tradit...
Transition Metal-Based Materials for Electrochemical and Photoelectrochemical Carbon-Free Nitrogen Cycling as H-Carrier [0.03%]
基于金属的材料在电化学和光电化学无碳氮循环中的应用作为H-载体
Yuankai Li,Qian Lei,Won Tae Hong et al.
Yuankai Li et al.
Ammonia, as a carbon-free nitrogen-based hydrogen carrier, has attracted significant interest in addressing the approaching energy model innovation in light of its high hydrogen content, low cost, ease of storage, and transport. However, th...