Baroreceptor-Inspired Microneedle Skin Patch for Pressure-Controlled Drug Release [0.03%]
一种基于压力感受器的微针皮肤贴片实现血压控制给药
Jiahui He,Mengjia Zheng,Tianli Hu et al.
Jiahui He et al.
Objective: We have developed a baroreceptor-inspired microneedle skin patch for pressure-controlled drug release. Impact Statement: This design is inspired by the skin baroreceptors, which are mechanosensitive elements of the peripheral ner...
Farzaneh Afkhami,Yuan Chen,Laurence J Walsh et al.
Farzaneh Afkhami et al.
Recent advancements in nanotechnology have introduced a myriad of potential applications in dentistry, with nanomaterials playing an increasing role in endodontics. These nanomaterials exhibit distinctive mechanical and chemical properties,...
Multifunctional Ablative Gastrointestinal Imaging Capsule (MAGIC) for Esophagus Surveillance and Interventions [0.03%]
多功能胃肠内镜胶囊(MAGIC)在食道监测和干预中的应用
Hyeon-Cheol Park,Dawei Li,Rongguang Liang et al.
Hyeon-Cheol Park et al.
Objective and Impact Statement: A clinically viable technology for comprehensive esophagus surveillance and potential treatment is lacking. Here, we report a novel multifunctional ablative gastrointestinal imaging capsule (MAGIC) technology...
Controllable Thrombolysis Using a Nanobubble-Imaging-Guided rtPA Targeted Delivery Strategy [0.03%]
一种纳米气泡成像引导的尿激酶原溶栓新策略
Jian Tang,Huiting Xu,Mingxi Li et al.
Jian Tang et al.
Objective: The objective of this work is to design and fabricate a novel multifunctional nanocarrier combining thrombus-targeted imaging and ultrasound-mediated drug delivery for the theranostics of thrombotic diseases. Impact Statement: Th...
Real-Time Reconstruction of HIFU Focal Temperature Field Based on Deep Learning [0.03%]
基于深度学习的HIFU焦点温度场实时重建方法研究
Shunyao Luan,Yongshuo Ji,Yumei Liu et al.
Shunyao Luan et al.
Objective and Impact Statement: High-intensity focused ultrasound (HIFU) therapy is a promising noninvasive method that induces coagulative necrosis in diseased tissues through thermal and cavitation effects, while avoiding surrounding dama...
Design and Evaluation of Synthetic Delivery Formulations for Peptide-Based Cancer Vaccines [0.03%]
用于基于肽的癌症疫苗的合成递送配方的设计与评估
Kefan Song,Suzie H Pun
Kefan Song
With the recent advances in neoantigen identification, peptide-based cancer vaccines offer substantial potential in the field of immunotherapy. However, rapid clearance, low immunogenicity, and insufficient antigen-presenting cell (APC) upt...
Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices [0.03%]
用于毫米级动物电生理学研究的电极设备
Kairu Dong,Wen-Che Liu,Yuyan Su et al.
Kairu Dong et al.
Millimeter-scale animals such as Caenorhabditis elegans, Drosophila larvae, zebrafish, and bees serve as powerful model organisms in the fields of neurobiology and neuroethology. Various methods exist for recording large-scale electrophysio...
Ge Wang
Ge Wang
In this perspective, "CASES" are made for AI in medicine. The CASES mean Confidence, Adaptability, Stability, Explainability, and Security of AI systems. We underline that these CASES can be addressed not only individually but also synergis...
Intracellular Protein Delivery: Approaches, Challenges, and Clinical Applications [0.03%]
细胞内蛋白质传递：方法、挑战和临床应用
Alexander Chan,Andrew Tsourkas
Alexander Chan
Protein biologics are powerful therapeutic agents with diverse inhibitory and enzymatic functions. However, their clinical use has been limited to extracellular applications due to their inability to cross plasma membranes. Overcoming this ...
Perspective: Limiting Antimicrobial Resistance with Artificial Intelligence/Machine Learning [0.03%]
展望：利用人工智能/机器学习限制抗菌素耐药性
Daniel Amsterdam
Daniel Amsterdam
The author traces his experience with the application of computers in clinical microbiology over the past 60 years, specifically in directing clinicians to treat bacterial infections diagnosed by the laboratory and the antibacterial agent(s...