TT-PADM: A Time-Driven Transformer Diffusion Model for Robust Sparse-View and Limited-View Photoacoustic Tomography [0.03%]
基于时间驱动的变压器扩散模型用于稳健的低视椎光声层析成像
Jiawei Zheng,Wende Dong,Junjun Sun et al.
Jiawei Zheng et al.
Objective: To develop a high-performance reconstruction framework that enables high-quality photoacoustic tomography (PAT) imaging under limited-view and sparse-view acquisition constraints. Impact Statement: The proposed method reduces the...
Adaptive Optimization of Vascular-Targeted Photodynamic Therapy Efficiency Based on Hyperspectral-Photoacoustic Dual-Modality Imaging Feedback [0.03%]
基于双模态光谱-photoacoustic反馈的血管靶向光动力疗法的自适应优化
Rongrui Zhang,Jingrui Zhao,Shasha Wang et al.
Rongrui Zhang et al.
Objective: To enhance vascular-targeted photodynamic therapy (V-PDT) efficacy by integrating real-time dosimetric monitoring and adaptive irradiance modulation based on dynamic physiological feedback. Impact Statement: This study presents a...
Nondestructive, High-Resolution T Cell Characterization and Subtyping via Deep-UV Microscopy [0.03%]
基于深紫外显微镜的T细胞高分辨非破坏式表征与分类
Viswanath Gorti,Caroline E Serafini,Aaron D Silva Trenkle et al.
Viswanath Gorti et al.
Objective and Impact Statement: We establish deep-ultraviolet (UV) microscopy as a fast, label-free, and simple imaging approach for assessing T cell viability, activation state, and subtype with high accuracy. Introduction: T cell characte...
Digital Twin Brain: Generating Multitask Behavior from Connectomes for Personalized Therapy [0.03%]
数字孪生大脑：利用连接组生成多任务行为以实现个性化治疗
Yuta Takahashi,Takafumi Soda,Hiroaki Tomita et al.
Yuta Takahashi et al.
Objective: This study introduces and validates a digital twin brain framework designed to translate an individual's brain connectome into predictions of multitask neurobehavioral dynamics and personalized functional modulations. Impact Stat...
Deep Learning-Enabled Virtual Multiplexed Immunostaining of Label-Free Tissue for Vascular Invasion Assessment [0.03%]
基于深度学习的无标签组织虚拟多重免疫染色在血管侵袭评估中的应用
Yijie Zhang,Çağatay Işıl,Xilin Yang et al.
Yijie Zhang et al.
Objective: We report the development and validation of a deep learning-based virtual multiplexed immunostaining method for label-free tissue, enabling the simultaneous generation of ERG (ETS-related gene), PanCK (pan-cytokeratin), and hemat...
Baicalein Alleviates Iron Overload-Induced Ferroptosis and Osteogenic Blockade in Osteoblasts by Activating the Nrf2/GPX4 Pathway [0.03%]
baicalein通过激活Nrf2/GPX4通路缓解铁过载诱导的成骨细胞ferropotosis及成骨障碍
Zengfeng Guo,Ningfeng Zhang,Junshen Huang et al.
Zengfeng Guo et al.
Objective: This study aimed to investigate the protective effects and underlying mechanisms of baicalein against iron overload-induced osteoblast dysfunction and bone loss. Impact Statement: This research is the first to demonstrate that ba...
Multiomics Machine Learning to Predict Neoadjuvant Chemotherapy Outcome and Relapse of Breast Cancer [0.03%]
乳腺癌新辅助化疗效果和复发的多组学机器学习预测模型
Lili Wang,Xiaodong Zhang,Jing Zhang et al.
Lili Wang et al.
Objective: The aim of this study was to investigate multiomics (MO) integration with stacked-ensemble learning for predicting neoadjuvant chemotherapy (NAC) response and recurrence risk in breast cancer (BC). Impact Statement: This study de...
Synergistic Antibacterial Activity of Fe3O4@mPEG-Ag Nanoparticles with Molecular Docking Analyses [0.03%]
基于分子对接分析的Fe3O4@mPEG-Ag纳米粒子的协同抗菌活性
Basit Ali Shah,Hongguo Zhu,Asma Sardar et al.
Basit Ali Shah et al.
Objective: This study aims to develop methoxy poly(ethylene glycol) (mPEG) and silver-modified magnetite nanoparticles termed Fe3O4@mPEG-Ag NPs as efficient non-antibiotic antibacterial agents to address the growing challenge of drug-resist...
Prussian Blue Nanoparticles Promoting Diabetic Bone Regeneration via Mitochondrial Recovery [0.03%]
普鲁士蓝纳米颗粒通过线粒体恢复促进糖尿病骨再生
Anqi Gu,An Lao,Weiqi Li et al.
Anqi Gu et al.
Objective: This work aims to develop Prussian blue (PB) nanoparticles that mitigate bone marrow mesenchymal stem cell (BMSC) senescence and alleviate bone loss in type 2 diabetes (T2D). Impact Statement: PB nanozymes are established as a ta...
Transmissive-Detected Hyperspectral Imaging for Single-Vessel-Resolution Blood Oxygen Mapping [0.03%]
用于单血管解析级血氧映射的透射式高光谱成像技术
Shaojun Liu,Qing Xia,Yuwei Du et al.
Shaojun Liu et al.
Objective: This study proposed a transmissive-detected hyperspectral imaging (TD-HSI) strategy for blood oxygen mapping in order to address the limitation of reflective HSI in obtaining high-resolution blood oxygen information from deep tis...