Multiomics Machine Learning to Predict Neoadjuvant Chemotherapy Outcome and Relapse of Breast Cancer [0.03%]
乳腺癌新辅助化疗效果和复发的多组学机器学习预测模型
Lili Wang,Xiaodong Zhang,Jing Zhang et al.
Lili Wang et al.
Objective: The aim of this study was to investigate multiomics (MO) integration with stacked-ensemble learning for predicting neoadjuvant chemotherapy (NAC) response and recurrence risk in breast cancer (BC). Impact Statement: This study de...
Synergistic Antibacterial Activity of Fe3O4@mPEG-Ag Nanoparticles with Molecular Docking Analyses [0.03%]
基于分子对接分析的Fe3O4@mPEG-Ag纳米粒子的协同抗菌活性
Basit Ali Shah,Hongguo Zhu,Asma Sardar et al.
Basit Ali Shah et al.
Objective: This study aims to develop methoxy poly(ethylene glycol) (mPEG) and silver-modified magnetite nanoparticles termed Fe3O4@mPEG-Ag NPs as efficient non-antibiotic antibacterial agents to address the growing challenge of drug-resist...
Prussian Blue Nanoparticles Promoting Diabetic Bone Regeneration via Mitochondrial Recovery [0.03%]
普鲁士蓝纳米颗粒通过线粒体恢复促进糖尿病骨再生
Anqi Gu,An Lao,Weiqi Li et al.
Anqi Gu et al.
Objective: This work aims to develop Prussian blue (PB) nanoparticles that mitigate bone marrow mesenchymal stem cell (BMSC) senescence and alleviate bone loss in type 2 diabetes (T2D). Impact Statement: PB nanozymes are established as a ta...
Transmissive-Detected Hyperspectral Imaging for Single-Vessel-Resolution Blood Oxygen Mapping [0.03%]
用于单血管解析级血氧映射的透射式高光谱成像技术
Shaojun Liu,Qing Xia,Yuwei Du et al.
Shaojun Liu et al.
Objective: This study proposed a transmissive-detected hyperspectral imaging (TD-HSI) strategy for blood oxygen mapping in order to address the limitation of reflective HSI in obtaining high-resolution blood oxygen information from deep tis...
Inference of Gene Regulatory Networks for Breast Cancer Based on Genetic Modules [0.03%]
基于遗传模块的乳腺癌基因调控网络推理方法研究
Yihao Chen,Ling Guo,Yue Pan et al.
Yihao Chen et al.
Objective: Breast cancer is a common tumor and has a high mortality rate. Gene regulatory networks(GRNs) can genetically facilitate targeted therapies for this disease. Impact Statement: This study proposes a new method to infer GRNs. This ...
Quantifying Spatiotemporal Heterogeneity of Tumor Metabolism and Vasculature with a Multiparametric Point-of-Investigation Microscope [0.03%]
具有多参数点检测功能的显微镜定量表征肿瘤代谢和血管的时空异质性
Enakshi D Sunassee,Marcia Cunha Dos Santos,Riley J Deutsch-Williams et al.
Enakshi D Sunassee et al.
Objective: The aim of this study was to develop and apply a dual-scale Capillary-Cell (CapCell) microscope to quantify spatial and temporal heterogeneity in tumor metabolism and vasculature during anti-angiogenic therapy. Impact Statement: ...
Christopher Bendkowski,Adam P Levine,Manuel Rodriguez-Justo et al.
Christopher Bendkowski et al.
Objective: This article describes a new method (VS-FPM) for analysis of unstained tissues based on the application of supervised machine learning to generate brightfield hematoxylin and eosin (H&E) images from phase images recovered using F...
Scoping the Landscape of Deep Learning for Alzheimer's Disease Stage Classification: Methods, Challenges, and Opportunities [0.03%]
深度学习在阿尔茨海默病分期分类中的方法、挑战与机遇综述
Salleh Sonko,Mohamed Islam Houssam,Kossi Dodzi Bissadu et al.
Salleh Sonko et al.
Deep learning (DL) models have been widely applied for Alzheimer's disease (AD) stage classification. This scoping review synthesizes recent research to evaluate current performance benchmarks, identify methodological limitations, and highl...
mPEG@ELA-11 Alleviates Atherosclerosis via AKT-ER Stress-Mediated Macrophage Modulation [0.03%]
mPEG@ELA-11通过AKT-内质网应激介导的巨噬细胞调节缓解动脉粥样硬化
Xiaoguang Li,Ning Dou,Linshan Zhong et al.
Xiaoguang Li et al.
Objective: This study explores the role of methoxy polyethylene glycol@Elabela-11 (mPEG@ELA-11), a pH-responsive ELA-11 conjugate, in modulating macrophage function and attenuating atherosclerosis, focusing on the protein kinase B (AKT)-med...
Sustainable Nanotechnology and Artificial Intelligence to Empower Image-Guided Therapy for Precision Healthcare [0.03%]
可持续纳米技术与人工智能赋能的图像引导治疗精准医疗
Drishya Prakashan,Ramya Pr,Ajeet Kaushik et al.
Drishya Prakashan et al.
Nanotechnology has substantially advanced imaging, therapy, and clinical techniques, playing a crucial role in the development of sustainable functional materials in biomedical engineering. Nanoparticles, used as contrast agents in multimod...