Inference of Gene Regulatory Networks for Breast Cancer Based on Genetic Modules [0.03%]
基于遗传模块的乳腺癌基因调控网络推理方法研究
Yihao Chen,Ling Guo,Yue Pan et al.
Yihao Chen et al.
Objective: Breast cancer is a common tumor and has a high mortality rate. Gene regulatory networks(GRNs) can genetically facilitate targeted therapies for this disease. Impact Statement: This study proposes a new method to infer GRNs. This ...
Quantifying Spatiotemporal Heterogeneity of Tumor Metabolism and Vasculature with a Multiparametric Point-of-Investigation Microscope [0.03%]
具有多参数点检测功能的显微镜定量表征肿瘤代谢和血管的时空异质性
Enakshi D Sunassee,Marcia Cunha Dos Santos,Riley J Deutsch-Williams et al.
Enakshi D Sunassee et al.
Objective: The aim of this study was to develop and apply a dual-scale Capillary-Cell (CapCell) microscope to quantify spatial and temporal heterogeneity in tumor metabolism and vasculature during anti-angiogenic therapy. Impact Statement: ...
Christopher Bendkowski,Adam P Levine,Manuel Rodriguez-Justo et al.
Christopher Bendkowski et al.
Objective: This article describes a new method (VS-FPM) for analysis of unstained tissues based on the application of supervised machine learning to generate brightfield hematoxylin and eosin (H&E) images from phase images recovered using F...
Scoping the Landscape of Deep Learning for Alzheimer's Disease Stage Classification: Methods, Challenges, and Opportunities [0.03%]
深度学习在阿尔茨海默病分期分类中的方法、挑战与机遇综述
Salleh Sonko,Mohamed Islam Houssam,Kossi Dodzi Bissadu et al.
Salleh Sonko et al.
Deep learning (DL) models have been widely applied for Alzheimer's disease (AD) stage classification. This scoping review synthesizes recent research to evaluate current performance benchmarks, identify methodological limitations, and highl...
mPEG@ELA-11 Alleviates Atherosclerosis via AKT-ER Stress-Mediated Macrophage Modulation [0.03%]
mPEG@ELA-11通过AKT-内质网应激介导的巨噬细胞调节缓解动脉粥样硬化
Xiaoguang Li,Ning Dou,Linshan Zhong et al.
Xiaoguang Li et al.
Objective: This study explores the role of methoxy polyethylene glycol@Elabela-11 (mPEG@ELA-11), a pH-responsive ELA-11 conjugate, in modulating macrophage function and attenuating atherosclerosis, focusing on the protein kinase B (AKT)-med...
Sustainable Nanotechnology and Artificial Intelligence to Empower Image-Guided Therapy for Precision Healthcare [0.03%]
可持续纳米技术与人工智能赋能的图像引导治疗精准医疗
Drishya Prakashan,Ramya Pr,Ajeet Kaushik et al.
Drishya Prakashan et al.
Nanotechnology has substantially advanced imaging, therapy, and clinical techniques, playing a crucial role in the development of sustainable functional materials in biomedical engineering. Nanoparticles, used as contrast agents in multimod...
Three-Dimensional Dynamic Cell Models for Metabolic Dysfunction-Associated Steatotic Liver Disease Progression [0.03%]
代谢功能障碍相关性脂肪肝病进展的三维动态细胞模型
Zhengxiang Huang,Lili Li,Kevin Dudley et al.
Zhengxiang Huang et al.
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex, progressive disorder involving multiple cell types, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), characte...
Construction of Silver-Calcium Micro-Galvanic Cell on Titanium for Immunoregulation Osteogenesis [0.03%]
银钙微电池调控钛植入体免疫反应促进骨诱导研究
Zhenhao Hou,Xingdan Liu,Xianming Zhang et al.
Zhenhao Hou et al.
Objective: This work aims to construct a functional titanium surface with spontaneous electrical stimulation for immune osteogenesis and antibacteria. Impact Statement: A silver-calcium micro-galvanic cell was engineered on the titanium imp...
Power-Driven Electroporation Is Predictive of Treatment Outcomes in a Conductivity-Independent Manner [0.03%]
一种与电导率无关的电穿孔驱动预测治疗结果的方法
Edward J Jacobs,Julio P Arroyo,Manali Powar et al.
Edward J Jacobs et al.
Objective: This study characterizes the effects of external conductivity on electroporation to develop methods to overcome potential patient-to-patient variability. Impact Statement: We demonstrate that constant power pulsed electric fields...
Tissue Engineering In Vitro Leaflet- and 3-Dimensional Printing-Based Implant Prototypes for Infant Mitral Valve [0.03%]
基于组织工程的瓣叶和三维打印制作的婴儿二尖瓣植入原型体外研究
Martha I González-Duque,Arielle Breuninger,Frédéric Leis et al.
Martha I González-Duque et al.
Objective: This study engineers leaflet- and 3-dimensional (3D) printing-based implant prototypes for infant mitral valve repair via in vitro cultured mesoangioblasts isolated from the human fetal aorta (AoMAB). Impact Statement: Ultrahigh-...