A General Biosensing Strategy Based on Cascade Amplification for Enhanced HIV Detection Sensitivity [0.03%]
一种基于级联扩增的普适性生物传感策略用于增强HIV检测灵敏度
Yirui Zhang,Jieyu Yan,Wangheng Hou et al.
Yirui Zhang et al.
Objective: Accurate and rapid detection of disease biomarkers is critical for early diagnosis, timely intervention, and effective disease management. Impact Statement: This strategy is exemplified through the development of 2 biosensors for...
Soft Robotics for Parkinson's Disease Supported by Functional Materials and Artificial Intelligence [0.03%]
功能材料和人工智能支持的软体机器人在帕金森病中的应用
Hirak Mazumdar,Kamil Reza Khondakar,Suparna Das et al.
Hirak Mazumdar et al.
Progressive neurodegenerative disease known as Parkinson's disease (PD) is characterized by both motor and nonmotor symptoms that severely reduce the quality of life. Recent developments in soft robotics provide customizable, cozy, and less...
Label-Free Evaluation of Lung and Heart Transplant Biopsies Using Tissue Autofluorescence-Based Virtual Staining [0.03%]
基于组织自体荧光的虚拟染色无标记评估肺移植和心脏移植活检标本
Yuzhu Li,Nir Pillar,Tairan Liu et al.
Yuzhu Li et al.
Objective and Impact Statement: We present a panel of virtual staining neural networks for lung and heart transplant biopsies, providing rapid and high-quality histological staining results while bypassing the traditional histochemical stai...
Revisiting Treatment Strategies: Addressing Epithelial-to-Mesenchymal Transition-Induced Resistance in Hepatocellular Carcinoma [0.03%]
治疗策略的重新思考——肝细胞癌上皮间质转化诱导的耐药性的应对措施
Roghayeh Naserkhaki,Bahare Shokouhian,Yaser Tahamtani et al.
Roghayeh Naserkhaki et al.
One of the major therapeutic challenges for hepatocellular carcinoma (HCC), the most form of primary liver cancer, is how to overcome drug resistance. Due to the high failure rate of systemic therapy in treating advanced HCC patients and th...
Finite Element Simulation of Interstitial-Lymphatic Fluid Flow and Nanodrug Transport in a Solid Tumor: An Intratumoral Injection Approach [0.03%]
固体肿瘤内间质-淋巴液流动及纳米药物传输的有限元仿真：一种瘤内注射方法
Gobinda Debnath,Buddakkagari Vasu,Rama Subba Reddy Gorla
Gobinda Debnath
Objective: This study presents a mathematical model and finite element simulations to investigate interstitial fluid flow and nanodrug transport in a solid tumor, incorporating transvascular exchange, convection-diffusion-reaction dynamics,...
A Systematic Review of Toxicity, Biodistribution, and Biosafety in Upconversion Nanomaterials: Critical Insights into Toxicity Mitigation Strategies and Future Directions for Safe Applications [0.03%]
上转换纳米材料的毒理学、生物分布和生物安全性的系统评价：降低毒性策略及未来安全应用的关键见解与发展动向
Imran Ahamed Khan,Ting Yu,Ming Yang et al.
Imran Ahamed Khan et al.
Upconversion nanoparticles (UCNPs) are emerging as highly promising nanomaterials due to their exceptional optical properties, enabling diverse applications in biosensing, bioimaging, photodynamic therapy, and drug delivery. However, their ...
Shilpa Borehalli Mayegowda,Manjula Nagalapur Gadilingappa
Shilpa Borehalli Mayegowda
Globally, increased illness and disorders have gained importance in improvising therapeutics to help extend the lifespan of an individual. In this scenario, understanding the mechanism of bacterial pathogenicity linked to the interaction be...
Application of CRISPR-Cas System in Human Papillomavirus Detection Using Biosensor Devices and Point-of-Care Technologies [0.03%]
CRISPR-Cas系统在生物传感器设备和即时诊断技术中检测人乳头瘤病毒的应用
Chang He,Yongqi Li,Jinkuan Liu et al.
Chang He et al.
Human papillomavirus (HPV) is the most common virus for genital tract infections. Cervical cancer ranks as the fourth most prevalent cancer globally, with over 99% of cases in women attributed to HPV infection. This infection continues to p...
Noninvasive Quantitative Compression Ultrasound Central Venous Pressure: A Clinical Pilot Study [0.03%]
无创定量压缩超声中心静脉压：临床初步研究
Alex T Jaffe,Roger Pallarès-López,Jeffrey K Raines et al.
Alex T Jaffe et al.
Objective: This is an initial study to validate central venous pressure (CVP) measurements derived from quantitative compression ultrasound (QCU). Impact Statement: This study is the first gold standard invasive validation of CVP estimation...
Graph-Based 3-Dimensional Spatial Gene Neighborhood Networks of Single Cells in Gels and Tissues [0.03%]
基于图形的凝胶和组织中单细胞的三维空间基因邻域网络
Zhou Fang,Kelsey Krusen,Hannah Priest et al.
Zhou Fang et al.
Objective: We developed 3-dimensional spatially resolved gene neighborhood network embedding (3D-spaGNN-E) to find subcellular gene proximity relationships and identify key subcellular motifs in cell-cell communication (CCC). Impact Stateme...