Do the pharmacokinetics of statins explain psychiatric symptom improvement from adjunctive statin prescribing in severe mental illness? Three target trial emulation studies [0.03%]
他汀类药物的药代动力学能解释严重精神疾病患者联合使用他汀类药物的症状改善情况吗？三项目标试验模拟研究
Naomi Launders,Alvin Richards-Belle,Sarah Hardoon et al.
Naomi Launders et al.
Background: Evidence regarding the efficacy of adjunct statins to treat severe mental illness (SMI) is mixed. The varying pharmacokinetic properties of statins mean that specific statin-antipsychotic combinations might im...
Lifestyle psychiatry: a conceptual framework for application in mental healthcare and support [0.03%]
生活方式精神病学：在心理健康护理和支持中的应用概念框架
Jeroen Deenik,Jentien M Vermeulen,Scott B Teasdale et al.
Jeroen Deenik et al.
Lifestyle-related behaviours-such as sedentary behaviour, physical inactivity, poor nutrition, disrupted sleep and substance use-are increasingly recognised as important factors in the onset and persistence of mental illness. Evidence for t...
Coffee intake is associated with telomere length in severe mental disorders [0.03%]
咖啡摄入量与严重精神障碍的端粒长度有关
Vid Mlakar,Marta Di Forti,Els F Halff et al.
Vid Mlakar et al.
Objective: Telomere length (TL) is an indicator of cellular ageing, with patients with severe mental disorders tending to have shorter telomeres than the general population. Coffee consumption may reduce oxidative stress,...
Prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopment trajectory: towards early warning via cohort- and metabolomics-based risk ranking [0.03%]
基于队列和代谢组学的风险分级指导环境化学污染物早期预警——以孕期全氟和多氟化合物暴露与儿童神经发育轨迹为例
Chang Gao,Ruonan Li,Hongyan Wu et al.
Chang Gao et al.
Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely affect neurodevelopment, but comparative risks and metabolic disruptions remain unclear. ...
Novel screening tool for psychiatric samples with major depressive disorder: a two-centre study [0.03%]
一项针对重度抑郁症患者的新型筛查工具：两项中心的研究
Nian Liu,Guangdong Hou,Xiayin Li et al.
Nian Liu et al.
Background: Major depressive disorder (MDD) poses a significant global public health challenge. Although the Patient Health Questionnaire-9 (PHQ-9) is widely used for MDD screening, its validation in psychiatric samples i...
Multicenter Study
BMJ mental health. 2025 Nov 13;28(1):e302021. DOI:10.1136/bmjment-2025-302021 2025
Daniel Freeman,Sinéad Lambe,Felicity Waite et al.
Daniel Freeman et al.
Background: To drive improvement in clinical services, an important innovation will be to regularly assess patients' psychotic experiences in order to guide, monitor and, when needed, alter treatment provision. The great ...
Gender and geographic disparities among DSM-5-TR authors in relation to financial conflicts of interest and industry payments: cross-sectional analysis [0.03%]
关于《精神疾病诊断与统计手册》第5版第4次修订版作者的性别和地域差异及其与财务利益冲突和行业支付的关系：横断面研究
Alexa T Diianni,Lauren C Davis,Brian J Piper
Alexa T Diianni
Objective: To evaluate gender and geographic representation (within the USA) and assess financial conflicts of interest and industry payments among task force, panel and cross-cutting review group members of the Diagnosti...
Jiao Wang,Jie Guo,Abigail Dove et al.
Jiao Wang et al.
Background: Poorer psychological and social well-being has been linked to increased mortality. Objective: To delineate the trajectories...
Temporal relationship between severe mental illness and neurological conditions in a UK primary care cohort [0.03%]
英国初级保健人群中严重精神疾病与神经系统疾病的时空关系
Ella Burchill,Jonathan P Rogers,David P J Osborn et al.
Ella Burchill et al.
Background: A higher prevalence of neurological conditions has been found in schizophrenia, bipolar disorder and other psychotic illnesses compared to the general population. We aimed to understand the cumulative prevalen...
Identifying modifiable factors and their joint associations on late-onset schizophrenia risk in the UK Biobank: a prospective exposure-wide association study [0.03%]
基于UK生物样本库的暴露广泛关联研究识别影响晚发性精神分裂症风险的因素及联合作用
Fan Jiang,Qiuyue Dong,Emilio Fernandez-Egea et al.
Fan Jiang et al.
Background: One in four cases of schizophrenia begins in late life, resulting in high unemployment and reduced life expectancy. However, knowledge of the modifiable risk factors for late-onset schizophrenia and their comb...