Meng Nie,Zeping Hu
Meng Nie
DDO1002, an NRF2-KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response [0.03%]
NRF2-KEAP1抑制剂DDO1002改善造血干细胞衰老和应激反应
Yuwen Li,Aiwei Wu,Xinrong Jin et al.
Yuwen Li et al.
Oxidative stress diminishes the functionality of hematopoietic stem cells (HSCs) as age advances, with heightened reactive oxygen species (ROS) levels exacerbating DNA damage, cellular senescence, and hematopoietic impairment. DDO1002, a po...
Targeted delivery of a cationic dendrimer with a plaque-homing peptide for the treatment of atherosclerosis [0.03%]
携带斑块趋向多肽的阳离子树枝状分子治疗动脉粥样硬化研究
Tarik Zahr,Tianyu Li,Divya Bhansali et al.
Tarik Zahr et al.
Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary [0.03%]
单细胞RNA测序揭示小鼠卵巢终生发生过程中的间质细胞的相互作用及调控景观
Wan Jiang,Wenya Sun,Yue Peng et al.
Wan Jiang et al.
The heterogeneity of ovarian mesenchymal/stromal cells has just been revealed in both mice and humans. However, it remains unclear about the cellular development trace and the intercellular communication network in the whole life of the ova...
Biallelic mutations in IQCN, encoding a novel acroplaxome protein, lead to fertilization failure and male infertility with defects in the acrosome and shaping of the spermatid head in humans and mice [0.03%]
人和小鼠IQCN基因的双等位基因突变导致人类和小鼠受精失败及精子头形状缺陷型男性不育
Yanwei Sha,Yongjie Chen,Xiong Wang et al.
Yanwei Sha et al.
Modeling maternal cholesterol exposure reveals a reduction of neural progenitor proliferation using human cerebral organoids [0.03%]
基于人体脑器官芯片的母体胆固醇暴露模型构建及其对神经干/干细胞增殖的影响研究
Pan Fan,Yuanhao Wang,Kaiqin Lu et al.
Pan Fan et al.
Maternal obesity raises the risk of high-cholesterol exposure for their offspring. Studies in cohorts and animal models report that maternal obesity could increase the risk of neurodevelopmental disorders in offspring including intellectual...
Waking up the silenced beauty: CRISPR/Cas9 mediated reactivation of fetal hemoglobin genes to treat severe beta-thalassemia in young patients [0.03%]
唤醒沉默的美：CRISPR / Cas9介导的胎儿血红蛋白基因再激活以治疗年轻患者的严重β型地中海贫血病
Liren Wang,Stefan Siwko,Dali Li
Liren Wang
Evolutionary conservation analysis of human arachidonic acid metabolism pathway genes [0.03%]
人花生四烯酸代谢途径基因的进化保守分析
Cengfan Wei,Meng Wang,Xiu-Jie Wang
Cengfan Wei
Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains [0.03%]
恢复羧肽酶E可使老年大脑中的脑源性神经营养因子成熟和神经发生恢复正常
Hongmei Liu,Dongfang Jiang,Fuwen Yao et al.
Hongmei Liu et al.
Adult neurogenesis declines with age due to the less functional neural stem cells (NSCs) and niches, but the underlying molecular bases for this impaired condition remain unclear. Here we analyzed >55,000 single-cell transcriptomes from two...
Xudong Zhang,Cesar de la Fuente-Nunez,Jun Wang
Xudong Zhang