Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD [0.03%]
空间多组学揭示GPR35相关脂质代谢标志物在MASLD肝脏区域化中的特征
Wuxiyar Otkur,Yiran Zhang,Yirong Li et al.
Wuxiyar Otkur et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and cancer. The zonal distribution of biomolecules in the liver...
Jianping Ye,Jun Yin
Jianping Ye
Type 2 diabetes mellitus (T2DM) is closely associated with obesity, while interactions between the two diseases remain to be fully elucidated. To this point, we offer this perspective to introduce a set of new insights into the interpretati...
Gut bacterial metabolism produces neuroactive steroids in pregnant women [0.03%]
妊娠妇女肠道细菌代谢产生神经活性类固醇
Kelsey E Huus,Ruth E Ley
Kelsey E Huus
Biphasic glucose-stimulated insulin secretion over decades: a journey from measurements and modeling to mechanistic insights [0.03%]
几十年来的双相葡萄糖刺激的胰岛素分泌：从测量和建模到机制见解的一次旅程
Xiaohong Peng,Kai Wang,Liangyi Chen
Xiaohong Peng
Glucose-stimulated insulin release from pancreatic β-cells is critical for maintaining blood glucose homeostasis. An abrupt increase in blood glucose concentration evokes a rapid and transient rise in insulin secretion followed by a prolon...
Chronic cold exposure reprograms feeding-regulated LPL activity in white adipose tissues through hepatic ANGPTL3 and ANGPTL8 [0.03%]
慢性寒冷暴露通过肝脏ANGPTL3和ANGPTL8重新编程白色脂肪组织中的喂养调节的LPL活性
Yiliang Zhang,Shengyang Zhou,Runming Zhao et al.
Yiliang Zhang et al.
Graphical Abstract Lipoprotein lipase (LPL) mediates peripheral tissue triglyceride (TG) uptake. Hepatic ANGPTL3 (A3) and ANGPTL8 (A8) form a complex and inhibit LPL activity in the white adipose tissue (WAT) via systematic circulation. ANG...
The deuterated glucose insulin tolerance test: a new tool to delineate insulin-stimulated glucose uptake from suppression of endogenous glucose production [0.03%]
氘代葡萄糖耐量试验：一个界定胰岛素刺激的葡萄糖摄取和抑制内源性葡萄糖产生的新工具
Christian A Unger,Marion C Hope rd,Michael Chase Kettering et al.
Christian A Unger et al.
Graphical Abstract. © The Author(s) 2024. Published by Oxford University Press on behalf of Higher Education Press.
Hai Wang,Zhiming Shao
Hai Wang
CIDEC/FSP27 exacerbates obesity-related abdominal aortic aneurysm by promoting perivascular adipose tissue inflammation [0.03%]
CIDEC/FSP27通过促进血管周围脂肪组织炎症加重肥胖相关性腹主动脉瘤
Qing Zhu,Da Luo,Yining Li et al.
Qing Zhu et al.
Abdominal aortic aneurysm (AAA) is strongly correlated with obesity, partially due to the abnormal expansion of abdominal perivascular adipose tissue (PVAT). Cell death-inducing DNA fragmentation factor-like effector C (CIDEC), also known a...
Glucose-6-phosphate dehydrogenase regulates mitophagy by maintaining PINK1 stability [0.03%]
葡萄糖六磷酸脱氢酶通过维持PINK1稳定性调节线粒体自噬
Yik-Lam Cho,Hayden Weng Siong Tan,Jicheng Yang et al.
Yik-Lam Cho et al.
Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) in glycolysis. Glucose metabolism is closely implicated in the regulation of mitophagy, a selective form of autophagy for the degrad...
Gut microbiota, immunity, and bile acid metabolism: decoding metabolic disease interactions [0.03%]
肠道微生物群、免疫和胆汁酸代谢：解码代谢性疾病间的相互作用
Qixiang Zhao,Jiayu Wu,Yong Ding et al.
Qixiang Zhao et al.
In recent decades, the global prevalence of metabolic syndrome has surged, posing a significant public health challenge. Metabolic disorders, encompassing diabetes, obesity, nonalcoholic fatty liver disease, and polycystic ovarian syndrome,...