Development of cyclopeptide inhibitors specifically disrupting FXR-coactivator interaction in the intestine as a novel therapeutic strategy for MASH [0.03%]
肠道FXR共激活剂相互作用的环肽抑制剂开发作为治疗MASH的新策略
Yazhou Li,Tingying Jiao,Xi Cheng et al.
Yazhou Li et al.
Intestinal farnesoid X receptor (FXR) antagonists have been proven to be efficacious in ameliorating metabolic diseases, particularly for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). All the reported FXR antagon...
Abigail Benvie,Valerie Horsley
Abigail Benvie
Calorie restriction plugs lithocholic bile acid into the lysosomal AMPK pathway [0.03%]
卡路里限制将石胆酸插入溶酶体AMPK通路
Benoit Viollet
Benoit Viollet
Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate [0.03%]
间歇性禁食通过肠道代谢物吲哚-3-丙酸抑制血小板活化和血栓形成
Zhiyong Qi,Luning Zhou,Shimo Dai et al.
Zhiyong Qi et al.
Platelet hyperreactivity contributes significantly to thrombosis in acute myocardial infarction and stroke. While antiplatelet drugs are used, residual ischemic risk remains. Intermittent fasting (IF), a dietary pattern characterized by alt...
Circulating short-chain and branched short-chain fatty acids and the risk of incident type 2 diabetes: findings from the 4C study [0.03%]
循环短链和支链脂肪酸与2型糖尿病发病风险的关系：4C研究的结果
Shuangyuan Wang,Hong Lin,Xiaojing Jia et al.
Shuangyuan Wang et al.
Previous studies suggested that fecal short-chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) are associated with glucose regulation. However, the potential relationship between circulating SCFAs and BCFAs with incident...
[This corrects the article DOI: 10.1093/lifemeta/loae034.]. © The Author(s) 2025. Published by Oxford University Press on behalf of Higher Education Pre...
Published Erratum
Life metabolism. 2025 Mar 10;4(2):loaf007. DOI:10.1093/lifemeta/loaf007 2025
Correction to: Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK [0.03%]
Correction to：由AXIN溶酶体易位介导的葡萄糖饥饿触发的以及AMPK介导的mTORC1抑制的层次结构
[This corrects the article DOI: 10.1093/lifemeta/load005.]. © The Author(s) 2025. Published by Oxford University Press on behalf of Higher Education Pre...
Published Erratum
Life metabolism. 2025 Feb 12;4(2):loaf003. DOI:10.1093/lifemeta/loaf003 2025
Serotonin signaling to regulate energy metabolism: a gut microbiota perspective [0.03%]
从肠道微生物组角度探讨五羟色胺信号对能量代谢的调节作用
Guoli Li,Sijing Dong,Chunhao Liu et al.
Guoli Li et al.
Serotonin is one of the most potent gastrointestinal, peripheral, and neuronal signaling molecules and plays a key role in regulating energy metabolism. Accumulating evidence has shown the complex interplay between gut microbiota and host e...
The FTO variant conferring enhanced UCP1 expression is linked to human migration out of Africa [0.03%]
与人类非洲迁徙相关的FTO基因变异可增强UCP1表达
Nan Yin,Dan Zhang,Jiqiu Wang
Nan Yin
Phytic acid-based nanomedicine against mTOR represses lipogenesis and immune response for metabolic dysfunction-associated steatohepatitis therapy [0.03%]
基于植酸的纳米药物通过抑制mTOR对抗脂质生成和免疫反应以治疗与代谢功能障碍相关的steatohepatitis
Fenghua Xu,Shoujie Zhao,Yejing Zhu et al.
Fenghua Xu et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases and is mainly caused by metabolic disorders and systemic inflammatory responses. Recent studies have indicated that the activation of t...