Baf60c in skeletal muscle regulates adipose tissue thermogenesis via Musclin-mediated endocrine signaling [0.03%]
骨骼肌中的Baf60c通过Musclin介导的内分泌信号调节脂肪组织产热作用
Shuang Han,Lu Jin,Wei Peng et al.
Shuang Han et al.
Skeletal muscle plays a key role in metabolic homeostasis. Brg1/Brm-associated factor (Baf) 60c, a subunit of the mating type switching/sucrose non-fermenting (SWI/SNF) chromatin remodeling complexes, was previously identified to be robustl...
Yingxi Xu,Chen Wang,Ping-Chih Ho
Yingxi Xu
Circadian rhythms are fundamental regulators of physiological processes, including immune function. Recent insights uncover that not only lymphocytes but also myeloid cells possess intrinsic circadian clocks that govern their behavior and f...
Dietary sulfur amino acid restriction improves metabolic health by reducing fat mass [0.03%]
饮食中的硫氨基酸限制通过减少脂肪量来改善代谢健康
Chenhao Xin,Mingcheng Cai,Qianxi Jia et al.
Chenhao Xin et al.
Diet interventions such as calorie restriction or time-restricted feeding offer potential for weight management, but long-term success is often hindered by poor adherence due to the rewarding effects of sugars. In this study, we demonstrate...
Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific regulatory mechanisms [0.03%]
脑-体组织的线粒体分布模式缺乏一致性并暗示了特定组织的调节机制
Jack Devine,Anna S Monzel,David Shire et al.
Jack Devine et al.
Energy transformation capacity is generally assumed to be a coherent individual trait driven by genetic and environmental factors. This predicts that some individuals should have consistently high, while others show consistently low mitocho...
Transporters in vitamin uptake and cellular metabolism: impacts on health and disease [0.03%]
维生素吸收和细胞代谢中的转运蛋白：对健康与疾病的影响
Yaxuan Yuan,Ligong Chen
Yaxuan Yuan
Vitamins are vital nutrients essential for metabolism, functioning as coenzymes, antioxidants, and regulators of gene expression. Their absorption and metabolism rely on specialized transport proteins that ensure bioavailability and cellula...
Optimized upstream analytical workflow for single-nucleus transcriptomics in main metabolic tissues [0.03%]
主要代谢组织单核转录组学的优化上游分析工作流程
Pengwei Dong,Shitong Ding,Guanlin Wang
Pengwei Dong
Development of cyclopeptide inhibitors specifically disrupting FXR-coactivator interaction in the intestine as a novel therapeutic strategy for MASH [0.03%]
肠道FXR共激活剂相互作用的环肽抑制剂开发作为治疗MASH的新策略
Yazhou Li,Tingying Jiao,Xi Cheng et al.
Yazhou Li et al.
Intestinal farnesoid X receptor (FXR) antagonists have been proven to be efficacious in ameliorating metabolic diseases, particularly for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). All the reported FXR antagon...
Abigail Benvie,Valerie Horsley
Abigail Benvie
Calorie restriction plugs lithocholic bile acid into the lysosomal AMPK pathway [0.03%]
卡路里限制将石胆酸插入溶酶体AMPK通路
Benoit Viollet
Benoit Viollet
Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate [0.03%]
间歇性禁食通过肠道代谢物吲哚-3-丙酸抑制血小板活化和血栓形成
Zhiyong Qi,Luning Zhou,Shimo Dai et al.
Zhiyong Qi et al.
Platelet hyperreactivity contributes significantly to thrombosis in acute myocardial infarction and stroke. While antiplatelet drugs are used, residual ischemic risk remains. Intermittent fasting (IF), a dietary pattern characterized by alt...