Zhi Li,Wei Meng,Zihan Gao et al.
Zhi Li et al.
Uric acid (UA) is a key intermediate in purine degradation across diverse organisms, while its accumulation in humans leads to inflammation and gout disease. Aerobic organisms degrade UA via a well-known "oxidative pathway" involving dearom...
Targeting complex IV to alter the tumor microenvironment and boost macrophage antitumor immunity [0.03%]
针对复合体IV以改变肿瘤微环境并增强巨噬细胞的抗肿瘤免疫能力
Thomas Pfefer,Luke A J O&#x;Neill
Thomas Pfefer
Clark et al. showcase that interferons (IFNs) trigger a functional reprogramming of tumor-associated macrophages (TAMs) by downregulating NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (NDUFA4), a key subunit of mitochondrial complex ...
RME-1-associated recycling endosomes participate in vitellogenin secretion in Caenorhabditis elegans [0.03%]
RME-1相关回收内体参与秀丽隐杆线虫卵黄蛋白原的分泌
Chao Zhai,Meng-Qiu Dong
Chao Zhai
Vitellogenins (VITs), the lipoprotein precursors of yolk proteins in Caenorhabditis elegans, are expressed in the intestine, secreted into the pseudocoelom, and ultimately transported into oocytes. However, the mechanism by which VITs are s...
Cryo-EM structure of the human MON1A-CCZ1-RAB7A complex provides insights into nucleotide exchange mechanism [0.03%]
人类MON1A-CCZ1-RAB7A复合物的冷冻电镜结构为核苷酸交换机制提供了见解
Xinna Li,Dan Li,Dan Tang et al.
Xinna Li et al.
Autophagy is a fundamental cellular process, conserved across species from yeast to mammals, that plays a crucial role in maintaining cellular homeostasis. The functionally conserved MON1-CCZ1 (MC1) complex serves as a guanine nucleotide ex...
Mom sweet, baby sad [0.03%]
妈甜，婴悲
Dongliang Lu,Xun Huang
Dongliang Lu
Building the adipose atlas: consensus guidelines and a standardized analytical workflow [0.03%]
构建脂肪图谱：共识指南和标准化分析流程
Life Metabolism Editorial Team
Life Metabolism Editorial Team
Life Metabolism Editorial Team
Life Metabolism Editorial Team
Liver ERα mediates sex differences in metabolic pattern changes in response to time-restricted feeding [0.03%]
肝脏ERα介导了限时喂养应激下代谢模式改变的性别差异响应
Haoqi Zhang,Tengteng Huang,Xianyang Jin et al.
Haoqi Zhang et al.
Time-restricted feeding (TRF) is a dietary strategy used to prevent and treat obesity in both sexes. However, TRF affects liver metabolism differently in males and females, and the mechanisms behind these differences remain unclear. Our stu...
Combination of time-restricted feeding with resistance exercise ameliorates MAFLD and improves glycemic homeostasis in obese mice [0.03%]
时间限制性进食与抵抗锻炼联合改善肥胖小鼠非酒精性脂肪肝及糖代谢紊乱
Guilherme Domingos Brisque,Ana Paula Azevêdo Macêdo,Guilherme Soderini Erlich et al.
Guilherme Domingos Brisque et al.
DHHC5 regulates lacteal function and intestinal lipid absorption by maintaining VEGFR2 localization in lipid rafts [0.03%]
DHHC5通过维持脂筏中VEGFR2定位来调节乳糜管功能和肠道脂质吸收
Yin-Yue Zhao,Yi-Fan Li,Jian-Wei Hao et al.
Yin-Yue Zhao et al.
The intestinal lymphatic system is essential for lipid absorption, yet its regulatory mechanisms remain poorly understood. Here, we identify DHHC5, an Asp-His-His-Cys (DHHC) motif-containing palmitoyl acyltransferase, as a critical regulato...