Glycine-GLRA1-calmodulin signaling regulates endoplasmic reticulum calcium to sustain insulin secretion and β-cell function [0.03%]
甘氨酸-GLRA1-钙调素信号通过调节内质网钙离子维持胰岛素分泌和β细胞功能
Jiarui Zhang,Zehui Cao,Jinbao Yang et al.
Jiarui Zhang et al.
Glycine, a non-essential amino acid, has been linked to improved metabolic health and enhanced insulin secretion, yet its mechanistic role in β-cell function remains poorly defined. Here, we identify a glycine-GLRA1-calmodulin signaling ax...
P5CS-coupled proline metabolism manipulates metabolic dysfunction-associated steatotic liver disease [0.03%]
P5CS介导的脯氨酸代谢重编程促进代谢紊乱相关非酒精性脂肪肝病发生发展
Zan Lyu,Sike Yu,Chang Peng et al.
Zan Lyu et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by hepatic steatosis, inflammation, and fibrosis, has reached epidemic proportions globally. Emerging evidence highlights a close association between amino acid...
Timekeepers of the gut: host circadian rhythms and microbial modulators [0.03%]
肠道的守护者：宿主生物钟和微生物调节因子
Xianda Ma,Qiyi Yu,Zheng Kuang
Xianda Ma
The intestine is more than a digestive organ. It is a system under circadian control, where cellular renewal, barrier integrity, absorption, immunity, and microbial ecology are orchestrated in time. Emerging evidence reveals that circadian ...
Jianhua Xiong
Jianhua Xiong
Urate metabolism in the gut [0.03%]
肠道尿酸代谢
Riccardo Percudani
Riccardo Percudani
Dan Zhang,Vini Tiwari,Christopher K Glass
Dan Zhang
Aberrant miR-378 expression promotes hepatic lipid accumulation via hijacking the bile acid-regulated autophagy [0.03%]
异常的miR-378表达通过劫持胆汁酸调节的自噬促进肝脏脂质积累
Zhoumin Niu,Ying Yan,Wei Liu et al.
Zhoumin Niu et al.
Dysregulated autophagy contributes to liver steatosis, yet its regulation under distinct metabolic contexts remains poorly defined. Here, we identify bile acids (BAs) as critical modulators of hepatic autophagy. Circulating BA levels are el...
Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36 [0.03%]
肝GH受体的缺失通过提高CD36参与瘦型MAFLD的发生发展机制
Dong Yu,Xiao Yang,Xiaonan Zhang et al.
Dong Yu et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver disease worldwide, affecting both obese and non-obese individuals. While the reduced levels of circulating growth hormone (GH) and insu...
Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut-liver axis [0.03%]
肠-肝轴抗氧化调节：阿克曼氏菌产生的丙酸缓解肝纤维化
Lu Zhang,Jing Chen,Si-Jia Ge et al.
Lu Zhang et al.
The gut commensal bacterium Akkermansia muciniphila (AKK) has emerged as a candidate for treating liver disorders, yet its therapeutic potential in liver fibrosis remains poorly defined. Here, using a carbon tetrachloride (CCl4)-induced mur...
The pathogenic theory of homeostasis threshold deviation (HTD) in wide-range oscillatory physiological parameters: novel perspectives for hypertension and metabolic disease treatment [0.03%]
生理参数波动下的稳态域阈值偏差(HDT)的致病理论：高血压和代谢性疾病的治疗新视角
Wei Sun,Jin-Yu Sun,Xiangqing Kong
Wei Sun
Based on current research in neuroscience, systems biology, and clinical medicine, we propose a novel theoretical concept: the "Homeostasis Threshold Deviation (HTD) Theory of Wide-Range Oscillatory Physiological Parameters". HTD posits tha...