Urate metabolism in the gut [0.03%]
肠道尿酸代谢
Riccardo Percudani
Riccardo Percudani
Dan Zhang,Vini Tiwari,Christopher K Glass
Dan Zhang
Aberrant miR-378 expression promotes hepatic lipid accumulation via hijacking the bile acid-regulated autophagy [0.03%]
异常的miR-378表达通过劫持胆汁酸调节的自噬促进肝脏脂质积累
Zhoumin Niu,Ying Yan,Wei Liu et al.
Zhoumin Niu et al.
Dysregulated autophagy contributes to liver steatosis, yet its regulation under distinct metabolic contexts remains poorly defined. Here, we identify bile acids (BAs) as critical modulators of hepatic autophagy. Circulating BA levels are el...
Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36 [0.03%]
肝GH受体的缺失通过提高CD36参与瘦型MAFLD的发生发展机制
Dong Yu,Xiao Yang,Xiaonan Zhang et al.
Dong Yu et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver disease worldwide, affecting both obese and non-obese individuals. While the reduced levels of circulating growth hormone (GH) and insu...
Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut-liver axis [0.03%]
肠-肝轴抗氧化调节：阿克曼氏菌产生的丙酸缓解肝纤维化
Lu Zhang,Jing Chen,Si-Jia Ge et al.
Lu Zhang et al.
The gut commensal bacterium Akkermansia muciniphila (AKK) has emerged as a candidate for treating liver disorders, yet its therapeutic potential in liver fibrosis remains poorly defined. Here, using a carbon tetrachloride (CCl4)-induced mur...
The pathogenic theory of homeostasis threshold deviation (HTD) in wide-range oscillatory physiological parameters: novel perspectives for hypertension and metabolic disease treatment [0.03%]
生理参数波动下的稳态域阈值偏差(HDT)的致病理论：高血压和代谢性疾病的治疗新视角
Wei Sun,Jin-Yu Sun,Xiangqing Kong
Wei Sun
Based on current research in neuroscience, systems biology, and clinical medicine, we propose a novel theoretical concept: the "Homeostasis Threshold Deviation (HTD) Theory of Wide-Range Oscillatory Physiological Parameters". HTD posits tha...
Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time [0.03%]
与烟酰胺类物质保持同步：NADP(H)，被遗忘的维持代谢节律的昼夜节律辅因子
Lauren Palluth,Joseph S Takahashi,Carla B Green
Lauren Palluth
The hierarchical relationship between the core circadian clock of the suprachiasmatic nucleus and peripheral clocks throughout the body is tightly regulated. Nicotinamide adenine dinucleotide phosphate (NADP(H)) is a rhythmic cofactor used ...
Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation [0.03%]
能量压力诱导的PKCζ S-谷氨酰化对LKB1胞浆转位和AMPK激活是必需的
Junjie Fei,Shuhan Yu,Mingzhe Xu et al.
Junjie Fei et al.
Energy stress triggers the activation of AMP-activated protein kinase (AMPK) via phosphorylation mediated by liver kinase B1 (LKB1). A pivotal step during this process is the translocation of protein kinase C zeta (PKCζ) to the nucleus, wh...
Well Met: RIPK1 senses S-adenosyl methionine to ensure cell survival [0.03%]
SAM维持细胞存活的新机制：RIPK1感应SAM水平抑制细胞焦亡
Piyush Sharma,Douglas R Green
Piyush Sharma
The brown fat-enriched exosomal miR-206-3p attenuates hepatic lipogenesis by decreasing pentose phosphate pathway [0.03%]
棕色脂肪细胞衍生的外泌体miR-206-3p通过抑制戊糖磷酸途径减少肝脏脂质合成
Li-Jie Yang,Qiu-Kai Tang,Lei Wang et al.
Li-Jie Yang et al.
Brown adipose tissue (BAT) orchestrates interorgan crosstalk through secreted mediators, including proteins, lipids, and exosomal microRNAs (miRNAs). However, the precise molecular identities and functional contributions of these mediators ...