Gestational progesterone restores menstrual cycle in PCOS patients via enhancing ovary estrogen production [0.03%]
孕酮通过增强卵巢雌激素产生恢复多囊卵巢综合征患者的月经周期
Qiwen Yang,Na Kong,Jing Wu et al.
Qiwen Yang et al.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, typically characterized by irregular menstrual cycles. Our study found that postpartum menstrual cycles were largely restored in PCOS pa...
Hepatocyte-specific DDAH1 regulates fasting-induced hepatic lipid metabolism via modulating FABP1 expression and AMPK/mTOR-mediated autophagy [0.03%]
肝细胞特异性DDAH1通过调节FABP1表达和AMPK/mTOR介导的自噬调控饥饿诱导的肝脏脂质代谢
Kai Luo,Xiyue Shen,Siyu Wang et al.
Kai Luo et al.
Under nutrient deprivation conditions, the liver maintains systemic energy homeostasis by mobilizing lipid reserves, a process often accompanied by hepatic lipid accumulation. Dimethylarginine dimethylaminohydrolase 1 (DDAH1), a key metabol...
Predictive value of 1-hour postprandial SPARC levels on metabolic outcomes from Mediterranean diet adherence: results from a randomized controlled feeding study [0.03%]
地中海饮食依从性受试者餐后1小时SPARC水平对代谢结局预测价值的随机对照喂食研究
Yanru Chen,Mengshan Ni,Yufei Chen et al.
Yanru Chen et al.
Precision nutrition is pivotal to preventing cardiometabolic diseases. However, almost no single blood biomarker capable of predicting the metabolic benefits of specific dietary patterns has yet been identified. Here, we revealed the associ...
Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis [0.03%]
透明质酸酶-1介导餐后肝糖异生的抑制作用
Xi Chen,Sophie Dogné,Yanru Deng et al.
Xi Chen et al.
Hepatic gluconeogenesis is a critical process that generates glucose from non-carbohydrate precursors during fasting to support vital organs like the brain and red blood cells. Postprandially, this process is rapidly suppressed to allow for...
Guang Lu,Han-Ming Shen
Guang Lu
Spatially segregated multiomics decodes metformin-mediated function-specific metabolic characteristics in diabetic kidney disease [0.03%]
空间分隔的多组学解码二甲双胍介导的糖尿病肾脏疾病中功能特异的代谢特征
Shi Qiu,Dandan Xie,Sifan Guo et al.
Shi Qiu et al.
Understanding the specific metabolic changes in multiple regions of the kidney is crucial to revealing the underlying mechanism and developing effective targets for diabetic nephropathy (DN). In this study, integrated spatially resolved met...
Structural insights into RAB7A activation: a mammalian perspective on the MON1A-CCZ1 GEF complex [0.03%]
RAB7A激活的结构见解：关于MON1A-CCZ1鸟苷交换因子复合物的哺乳动物视角
Life Metabolism Editorial Team
Life Metabolism Editorial Team
Weight loss maintenance after tirzepatide cessation in people with overweight/obesity: a real-world follow-up of the phase 3 SURMOUNT-CN trial [0.03%]
中国受试者使用 Tirzepatide 治疗后停止给药的体重维持：SURMOUNT-CN 三期研究的真实世界随访结果
Congling Chen,Zhen Ying,Qi Tang et al.
Congling Chen et al.
Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown unprecedented efficacy in weight loss and improving metabolic parameters in clinical trials. However, the durability of these benefits after treatment cessation remains poorly unders...
Correction to: Phytic acid-based nanomedicine against mTOR represses lipogenesis and immune response for metabolic dysfunction-associated steatohepatitis therapy [0.03%]
Correction to：基于植酸的纳米药物通过抑制mTOR对抗脂质生成和免疫反应以治疗与代谢功能障碍相关的肝炎疗法
[This corrects the article DOI: 10.1093/lifemeta/loae026.]. © The Author(s) 2026. Published by Oxford University Press on behalf of Higher Education Pre...
Published Erratum
Life metabolism. 2026 Apr 27;5(1):loaf043. DOI:10.1093/lifemeta/loaf043 2026
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction [0.03%]
短期禁食期间跨组织可变剪接程序的功能整合性增强
Daniel P Phillips,Sharon E Mitchell,Davina Derous et al.
Daniel P Phillips et al.
Alternative splicing (AS) involves production of several different RNA molecules from a single pre-mRNA. Calorie restriction (CR) is a sustained calorie deficit without malnutrition, which extends health and lifespan. AS is dysregulated in ...