Guang Lu,Han-Ming Shen
Guang Lu
Spatially segregated multiomics decodes metformin-mediated function-specific metabolic characteristics in diabetic kidney disease [0.03%]
空间分隔的多组学解码二甲双胍介导的糖尿病肾脏疾病中功能特异的代谢特征
Shi Qiu,Dandan Xie,Sifan Guo et al.
Shi Qiu et al.
Understanding the specific metabolic changes in multiple regions of the kidney is crucial to revealing the underlying mechanism and developing effective targets for diabetic nephropathy (DN). In this study, integrated spatially resolved met...
Structural insights into RAB7A activation: a mammalian perspective on the MON1A-CCZ1 GEF complex [0.03%]
RAB7A激活的结构见解：关于MON1A-CCZ1鸟苷交换因子复合物的哺乳动物视角
Life Metabolism Editorial Team
Life Metabolism Editorial Team
Weight loss maintenance after tirzepatide cessation in people with overweight/obesity: a real-world follow-up of the phase 3 SURMOUNT-CN trial [0.03%]
中国受试者使用 Tirzepatide 治疗后停止给药的体重维持：SURMOUNT-CN 三期研究的真实世界随访结果
Congling Chen,Zhen Ying,Qi Tang et al.
Congling Chen et al.
Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown unprecedented efficacy in weight loss and improving metabolic parameters in clinical trials. However, the durability of these benefits after treatment cessation remains poorly unders...
Correction to: Phytic acid-based nanomedicine against mTOR represses lipogenesis and immune response for metabolic dysfunction-associated steatohepatitis therapy [0.03%]
Correction to：基于植酸的纳米药物通过抑制mTOR对抗脂质生成和免疫反应以治疗与代谢功能障碍相关的肝炎疗法
[This corrects the article DOI: 10.1093/lifemeta/loae026.]. © The Author(s) 2026. Published by Oxford University Press on behalf of Higher Education Pre...
Published Erratum
Life metabolism. 2026 Apr 27;5(1):loaf043. DOI:10.1093/lifemeta/loaf043 2026
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction [0.03%]
短期禁食期间跨组织可变剪接程序的功能整合性增强
Daniel P Phillips,Sharon E Mitchell,Davina Derous et al.
Daniel P Phillips et al.
Alternative splicing (AS) involves production of several different RNA molecules from a single pre-mRNA. Calorie restriction (CR) is a sustained calorie deficit without malnutrition, which extends health and lifespan. AS is dysregulated in ...
Glycine-GLRA1-calmodulin signaling regulates endoplasmic reticulum calcium to sustain insulin secretion and β-cell function [0.03%]
甘氨酸-GLRA1-钙调素信号通过调节内质网钙离子维持胰岛素分泌和β细胞功能
Jiarui Zhang,Zehui Cao,Jinbao Yang et al.
Jiarui Zhang et al.
Glycine, a non-essential amino acid, has been linked to improved metabolic health and enhanced insulin secretion, yet its mechanistic role in β-cell function remains poorly defined. Here, we identify a glycine-GLRA1-calmodulin signaling ax...
P5CS-coupled proline metabolism manipulates metabolic dysfunction-associated steatotic liver disease [0.03%]
P5CS介导的脯氨酸代谢重编程促进代谢紊乱相关非酒精性脂肪肝病发生发展
Zan Lyu,Sike Yu,Chang Peng et al.
Zan Lyu et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by hepatic steatosis, inflammation, and fibrosis, has reached epidemic proportions globally. Emerging evidence highlights a close association between amino acid...
Timekeepers of the gut: host circadian rhythms and microbial modulators [0.03%]
肠道的守护者：宿主生物钟和微生物调节因子
Xianda Ma,Qiyi Yu,Zheng Kuang
Xianda Ma
The intestine is more than a digestive organ. It is a system under circadian control, where cellular renewal, barrier integrity, absorption, immunity, and microbial ecology are orchestrated in time. Emerging evidence reveals that circadian ...
Jianhua Xiong
Jianhua Xiong