Charles Brenner
Charles Brenner
It is central to biology that sequence conservation suggests functional conservation. Animal longevity is an emergent property of selected traits that integrates capacities to perform physical and mental functions after reproductive maturit...
John R Speakman,Joel K Elmquist
John R Speakman
People completely lacking body fat (lipodystrophy/lipoatrophy) and those with severe obesity both show profound metabolic and other health issues. Regulating levels of body fat somewhere between these limits would, therefore, appear to be a...
WTAP regulates postnatal development of brown adipose tissue by stabilizing METTL3 in mice [0.03%]
WTAP通过在小鼠中稳定METTL3调节棕色脂肪组织的产后发育
Brown adipocyte maturation during postnatal development is essential for brown adipose tissue (BAT) to protect animals against cold. Impaired maturation of brown adipocytes leads to cold intolerance. However, the molecular mechanisms that d...
Lowering low-density lipoprotein cholesterol: from mechanisms to therapies [0.03%]
降低低密度脂蛋白胆固醇：从机制到治疗
Low-density lipoprotein (LDL) is the main carrier of cholesterol and cholesteryl ester in circulation. High plasma levels of LDL cholesterol (LDL-C) are a major risk factor of atherosclerotic cardiovascular disease (ASCVD). LDL-C lowering i...
Potential therapeutic strategies for MASH: from preclinical to clinical development [0.03%]
MASH的潜在治疗策略：从临床前研究到临床开发
Current treatment paradigms for metabolic dysfunction-associated steatohepatitis (MASH) are based primarily on dietary restrictions and the use of existing drugs, including anti-diabetic and anti-obesity medications. Given the limited numbe...
Regulation of DNA translocation of chromatin remodeler enzyme Chd1 by exit DNA unwrapping [0.03%]
染色质重塑酶Chd1的DNA出丝位点调控及其解缠机制研究
Nucleosomes are the fundamental unit of chromatin. Chromatin remodeler plays a crucial role in the regulation of gene expression in eukaryotes. It is involved in important physiological processes, such as development, immune response, and m...