Lowering low-density lipoprotein cholesterol: from mechanisms to therapies [0.03%]
降低低密度脂蛋白胆固醇：从机制到治疗
Low-density lipoprotein (LDL) is the main carrier of cholesterol and cholesteryl ester in circulation. High plasma levels of LDL cholesterol (LDL-C) are a major risk factor of atherosclerotic cardiovascular disease (ASCVD). LDL-C lowering i...
Potential therapeutic strategies for MASH: from preclinical to clinical development [0.03%]
MASH的潜在治疗策略：从临床前研究到临床开发
Current treatment paradigms for metabolic dysfunction-associated steatohepatitis (MASH) are based primarily on dietary restrictions and the use of existing drugs, including anti-diabetic and anti-obesity medications. Given the limited numbe...
Regulation of DNA translocation of chromatin remodeler enzyme Chd1 by exit DNA unwrapping [0.03%]
染色质重塑酶Chd1的DNA出丝位点调控及其解缠机制研究
Nucleosomes are the fundamental unit of chromatin. Chromatin remodeler plays a crucial role in the regulation of gene expression in eukaryotes. It is involved in important physiological processes, such as development, immune response, and m...