AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1 [0.03%]
AMPK通过卵泡素：FNIP1促进溶酶体和线粒体的生物发生
Jordana B Freemantle,D Grahame Hardie
Jordana B Freemantle
The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing ly...
Qian Shi,Duane D Hall,Long-Sheng Song
Qian Shi
In a recent study published in Life Metabolism, Quan et al. reported that intracellular Ca2+ dysregulation in cardiomyocyte can be both a cause and an effect of cardiac insulin resistance that ultimately leads to diabetic cardiomyopathy.
Hanlin Zhang,Xinyu Li,Wudi Fan et al.
Hanlin Zhang et al.
Mitochondria function as a hub of the cellular metabolic network. Mitochondrial stress is closely associated with aging and a variety of diseases, including neurodegeneration and cancer. Cells autonomously elicit specific stress responses t...
Kevin C Klatt,Kevin Bass,John R Speakman et al.
Kevin C Klatt et al.
Diet plays a substantial role in the etiology, progression, and treatment of chronic disease and is best considered as a multifaceted set of modifiable input variables with pleiotropic effects on a variety of biological pathways spanning mu...
Vishal Musale,David H Wasserman,Li Kang
Vishal Musale
Obesity causes extracellular matrix (ECM) remodelling which can develop into serious pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM components may be increased in response to overnutrition. This revie...
Min Peng,Ming O Li
Min Peng
T cells are one of few cell types in adult mammals that can proliferate extensively and differentiate diversely upon stimulation, which serves as an excellent example to dissect the metabolic basis of cell fate decisions. During the last de...
Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity [0.03%]
肥胖小鼠腹脂巨噬细胞PPARγ乙酰化促进血管炎症及内脏脂肪退行性变
Nicole Aaron,Tarik Zahr,Ying He et al.
Nicole Aaron et al.
Obesity is characterized by chronic, low-grade inflammation, which is driven by macrophage infiltration of adipose tissue. PPARγ is well established to have an anti-inflammatory function in macrophages, but the mechanism that regulates its...
Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice [0.03%]
肥胖小鼠体重减轻可增加骨骼肌线粒体能量利用效率
Patrick J Ferrara,Marisa J Lang,Jordan M Johnson et al.
Patrick J Ferrara et al.
Weight loss from an overweight state is associated with a disproportionate decrease in whole-body energy expenditure that may contribute to the heightened risk for weight regain. Evidence suggests that this energetic mismatch originates fro...
Juan Wang,Guosheng Liang,Tong-Jin Zhao
Juan Wang
In a recent article published in Nature, Patel et al. identified adipose triglyceride lipase (ATGL, also known as patatin-like phospholipase domain containing 2) as the first biosynthetic enzyme of fatty acid esters of hydroxy fatty acids (...
Charles Brenner
Charles Brenner
It is central to biology that sequence conservation suggests functional conservation. Animal longevity is an emergent property of selected traits that integrates capacities to perform physical and mental functions after reproductive maturit...