Oliver K Fuller,Casey L Egan,Tina L Robinson et al.
Oliver K Fuller et al.
Obesity has been linked to a range of pathologies, including dementia. In contrast, regular physical activity is associated with the prevention or reduced progression of neurodegeneration. Specifically, physical activity can improve memory ...
David Sokolov,Lucas B Sullivan
David Sokolov
Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation [0.03%]
白细胞介素-10抑制脂代谢介导的肠黏膜炎症反应
Tristram A J Ryan,Ivan Zanoni
Tristram A J Ryan
In a recent paper published in Nature, York et al. reported that the anti-inflammatory cytokine IL-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation. Deletion of Il10 in mice, or genetic mutation of IL10 in humans, ...
Senescent glia-bridging neuronal mitochondrial dysfunction and lipid accumulation in aging [0.03%]
衰老的胶质细胞：连接神经元线粒体功能障碍和脂质积累的作用
Joel F Reyes,Mahima Devarajan,Dongming Cai et al.
Joel F Reyes et al.
Hypoxia makes EZH2 inhibitor not easy-advances of crosstalk between HIF and EZH2 [0.03%]
缺氧致EZH2抑制失效-HIF与EZH2互作进展
Zhanya Huang,Yuanjun Tang,Jianlin Zhang et al.
Zhanya Huang et al.
Histone methylation plays a crucial role in tumorigenesis. Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that regulates chromatin structure and gene expression. EZH2 inhibitors (EZH2is) have been shown to be effective in...
Jacques Togo,Hoon-Ki Sung
Jacques Togo
Anna S Monzel,Michael Levin,Martin Picard
Anna S Monzel
Major life transitions are always difficult because change costs energy. Recent findings have demonstrated how mitochondrial oxidative phosphorylation (OxPhos) defects increase the energetic cost of living, and that excessive integrated str...
Ruoxi Zhang,Guido Kroemer,Daolin Tang
Ruoxi Zhang
Size matters: the biochemical logic of ligand type in endocrine crosstalk [0.03%]
尺寸问题：内分泌相互作用中配体类型生化逻辑
Jameel Barkat Lone,Jonathan Z Long,Katrin J Svensson
Jameel Barkat Lone
The endocrine system is a fundamental type of long-range cell-cell communication that is important for maintaining metabolism, physiology, and other aspects of organismal homeostasis. Endocrine signaling is mediated by diverse blood-borne l...
Yuelong Yan,Boyi Gan
Yuelong Yan
The lack of a reliable and specific marker for ferroptosis has hindered the advancement of treatments related to this cell death mechanism toward clinical application. A recent study published in Molecular Cell has identified hyperoxidized ...