Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation [0.03%]
鸦片生长因子受体通过促进脂质氧化来增强脂肪组织产热作用
Shan Zhang,Jianhui Chen,Qingqing Li et al.
Shan Zhang et al.
The thermogenic brown and beige adipocytes consume fatty acids and generate heat to maintain core body temperature in the face of cold challenges. Since their validated presence in humans, the activation of thermogenic fat has been an attra...
Safety and immunogenicity of a modified COVID-19 mRNA vaccine, SYS6006, as a fourth-dose booster following three doses of inactivated vaccines in healthy adults: an open-labeled Phase 1 trial [0.03%]
有关SYS6006改良型新冠病毒mRNA疫苗作为灭活疫苗第三剂加强免疫后的第四剂开展的I期开放标记临床试验的安全性与免疫原性：健康成人参与者
Yuzhou Gui,Ye Cao,Jiajin He et al.
Yuzhou Gui et al.
The continuous emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants led to a rapid decline in protection efficacy and neutralizing titers even after three doses of COVID-19 vaccines. Here, we report an open...
Three 700$ awards available from Life Metabolism to support conference attendance [0.03%]
三项700美元的奖项等待您的申请，支持代谢和寿命研究学术会议参会
John R Speakman
John R Speakman
Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK [0.03%]
AXIN通过溶酶体转位和AMPK对葡萄糖缺乏引起的mTORC1分层抑制
Mengqi Li,Xiaoyan Wei,Jinye Xiong et al.
Mengqi Li et al.
When glucose is replete, mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is active and anchored to the lysosomal surface via the two GTPases, Ras-related GTPase (RAG) and Ras homolog enriched in brain (Rheb), which are regulate...
Glutathione restoration: a sword to combat skeletal muscle stem cell aging [0.03%]
谷胱甘肽恢复：对抗骨骼肌干细胞衰老的利剑
Zeming Wu,Jie Ren,Guang-Hui Liu
Zeming Wu
Shiyu Liu,Jason W Locasale
Shiyu Liu
Metabolic restraining of epigenetic modifications promotes cardiomyocyte proliferation [0.03%]
代谢限制表观遗传修饰促进心肌细胞增殖
Xiuxiu Liu,Bin Zhou
Xiuxiu Liu
Xiaoli Ma,Hong Zhang
Xiaoli Ma
Hepatic TRPC3 loss contributes to chronic alcohol consumption-induced hepatic steatosis and liver injury in mice [0.03%]
小鼠慢性酒精摄取致肝脏脂肪变性和肝损伤过程中HEPATIC TRPC3缺失的作用及其机制研究
Qinchao Ding,Rui Guo,Liuyi Hao et al.
Qinchao Ding et al.
Emerging evidence discloses the involvement of calcium channel protein in the pathological process of liver diseases. Transient receptor potential cation channel subfamily C member 3 (TRPC3), a ubiquitously expressed non-selective cation ch...
Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern [0.03%]
肠道单羧酸转运蛋白1介导乳酸转运并以性别二态模式调节小鼠代谢稳态
Shuo Wang,Lingling Zhang,Jingyu Zhao et al.
Shuo Wang et al.
The monocarboxylate transporter 1 (MCT1), encoded by gene Slc16a1, is a proton-coupled transporter for lactate and other monocarboxylates. MCT1-mediated lactate transport was recently found to regulate various biological functions. However,...