IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbing α-ketoglutarate-related metabolism and epigenetic modification [0.03%]
IDH1突变通过干扰α-酮戊二酸相关的代谢和表观遗传修饰抑制低氧化谷草转氨酶表达的星形胶质细胞及胶质瘤细胞的分化
Yuanlin Zhao,Ying Yang,Risheng Yang et al.
Yuanlin Zhao et al.
Isocitrate dehydrogenase (IDH) mutations frequently occur in lower-grade gliomas and secondary glioblastomas. Mutant IDHs exhibit a gain-of-function activity, leading to the production of D-2-hydroxyglutarate (D-2HG) by reducing α-ketoglut...
Lipidomic remodeling during mammalian preimplantation embryonic development [0.03%]
哺乳动物植入前胚胎发育过程中的脂质组重塑
Qingran Kong,Shaorong Gao
Qingran Kong
Mark P Mattson
Mark P Mattson
Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH [0.03%]
脂肪酸氧化诱导的HIF-1α活化通过上调NT5C2和XDH促进肝脏尿酸合成
Ningning Liang,Xuan Yuan,Lili Zhang et al.
Ningning Liang et al.
Dyslipidemia affects approximately half of all people with gout, and prior Mendelian randomization analysis suggested a causal role for elevated triglycerides in hyperuricemia (HU), but the underlying mechanisms remain elusive. We hypothesi...
Maria Delgado-Martin,Qiaoqiao Zhang,Lawrence Kazak
Maria Delgado-Martin
High temperature ameliorates high-fat diet-induced obesity by promoting ceramide breakdown in skeletal muscle tissue [0.03%]
高温通过促进骨骼肌组织中的鞘氨醇脂质降解来缓解高脂肪饮食引起的肥胖问题
Qiankun Wang,Lupeng Chen,Junzhi Zhang et al.
Qiankun Wang et al.
Obesity is considered an epidemic often accompanied by insulin resistance (IR). Heat treatment (HT) has been shown to prevent high-fat diet-induced IR in skeletal muscle, but the underlying mechanisms are poorly understood. In this study, w...
Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study [0.03%]
一项全国性队列研究：探索中国成年人心血管代谢表型和脂质组特征的年龄和性别差异
Xiaojing Jia,Hong Lin,Ruizhi Zheng et al.
Xiaojing Jia et al.
Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention strategies. We aim to investigate age-related sex disparity in cardiometabolic phenotypes in a large nationwi...
Hadrien Demagny,Alessia Perino,Kristina Schoonjans
Hadrien Demagny
Downregulation of RhoA/ROCK1/YAP/F-actin causing decreased aortic smooth muscle cell stiffness promotes aortic dissection formation [0.03%]
RhoA/ROCK1/YAP/F-肌动蛋白下调导致降主动脉平滑肌细胞刚度降低促进剥离性动脉瘤形成
Wei Zhang,Mengxiao Wang,Enci Wang et al.
Wei Zhang et al.
Downregulated RhoA/ROCK1/YAP/F-actin axis leads to decreased AoSMC stiffness and promotes AD formation. © The Author(s) 2024. Published by Oxford Univer...
Lipid metabolism in tumor-infiltrating T cells: mechanisms and applications [0.03%]
肿瘤浸润T细胞中的脂质代谢：机制及应用
Xin-Yu Ke,Miaowen Zou,Chenqi Xu
Xin-Yu Ke
As an essential part of adaptive immunity, T cells coordinate the immune responses against pathogens and cancer cells. Lipid metabolism has emerged as a key regulator for the activation, differentiation, and effector functions of T cells. T...