Jingyi Guo,Yunhao Zhou,Dingfei Liu et al.
Jingyi Guo et al.
Mitochondria are well known to be "energy factories" of the cell as they provide intracellular ATP via oxidative phosphorylation. Interestingly, they also function as a "cellular suicidal weapon store" by acting as a key mediator of various...
Impaired condensate formation is to blame for failed disease resistance in plants [0.03%]
凝集反应受损是植物病害抗性失败的罪魁祸首
Xiu-Fang Xin,Jian-Min Zhou
Xiu-Fang Xin
Long Yan,Hongmei Wang
Long Yan
Dongming Zhang,Dongsheng Cai
Dongming Zhang
Functional diversity and metabolic engineering of plant-specialized metabolites [0.03%]
植物次生代谢产物的功能多样性及其代谢工程学
Shaoqun Zhou,Yongshuo Ma,Yi Shang et al.
Shaoqun Zhou et al.
Plants are talented biochemists that produce a broad diversity of small molecules. These so-called specialized metabolites (SMs) play critical roles in the adaptive evolution of plants to defend against biotic and abiotic stresses, attract ...
Promotion of nonalcoholic steatohepatitis by RNA N6-methyladenosine reader IGF2BP2 in mice [0.03%]
N6-甲基腺苷阅读蛋白IGF2BP2通过促进非酒精性脂肪肝向非酒精性脂肪肝炎的转化来恶化肝脏炎症和纤维化
Bing Zhou,Yunchen Luo,Nana Ji et al.
Bing Zhou et al.
Nonalcoholic steatohepatitis (NASH) has emerged as the major cause of end-stage liver diseases. However, an incomplete understanding of its molecular mechanisms severely dampens the development of pharmacotherapies. In the present study, th...
The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice [0.03%]
新生酮体对小鼠原始卵泡池的形成及卵巢衰老的调控作用
Xin-Ying Wang,Xin-Ge Zhang,Yong-Juan Sang et al.
Xin-Ying Wang et al.
Adverse nutritional conditions during the perinatal stage are related to early menopause in adulthood; however, the underlying mechanism is still unclear. Herein, we revealed that colostrum-activated ketone body elevation during the postnat...
Bin Liang,Jennifer L Watts
Bin Liang
Reduced phosphatidylcholine synthesis suppresses the embryonic lethality of seipin deficiency [0.03%]
卵磷脂合成减少可抑制内质网蛋白seipin缺陷引起的胚胎致死性
Jinglin Zhu,Sin Man Lam,Leilei Yang et al.
Jinglin Zhu et al.
Seipin plays a vital role in lipid droplet homeostasis, and its deficiency causes congenital generalized lipodystrophy type II in humans. It is not known whether the physiological defects are all caused by cellular lipid droplet defects. Lo...
Intergenerational hyperglycemia through epigenetic alterations of gametes [0.03%]
生殖细胞表观遗传修饰改变介导的跨代高血糖症
Fei Mao,Xiaoying Li
Fei Mao