Callen C Goldsmith,Garron T Dodd
Callen C Goldsmith
Zhongsheng Wu,Yongtao Du,Tom Kirchhausen et al.
Zhongsheng Wu et al.
Distinct phospholipid species display specific distribution patterns across cellular membranes, which are important for their structural and signaling roles and for preserving the integrity and functionality of the plasma membrane and organ...
BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer [0.03%]
BET抑制通过GDH1依赖性谷氨酰胺代谢重组诱导肝癌细胞的脆弱性
Wen Mi,Jianwei You,Liucheng Li et al.
Wen Mi et al.
Bromodomain and extra-terminal domain (BET) proteins, which function partly through MYC proto-oncogene (MYC), are critical epigenetic readers and emerging therapeutic targets in cancer. Whether and how BET inhibition simultaneously induces ...
Cholesin, a new hormone bridges intestinal cholesterol absorption and hepatic synthesis [0.03%]
新的激素连接肠道胆固醇吸收和肝脏合成
Peter U Amadi,Da-Wei Zhang
Peter U Amadi
Apolipoprotein A-IV and its derived peptide, T55-121, improve glycemic control and increase energy expenditure [0.03%]
载脂蛋白A-IV及其衍生多肽T55-121可通过改善糖代谢和增加能量消耗来缓解肥胖和胰岛素抵抗
Zhen Cao,Lei Lei,Ziyun Zhou et al.
Zhen Cao et al.
It is crucial to understand the glucose control within our bodies. Bariatric/metabolic surgeries, including laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB), provide an avenue for exploring the potential key factors...
Genome-wide CRISPR screens identify PTPN21 and WDR26 as modulators of the mitochondrial stress-induced ISR [0.03%]
全基因组CRISPR筛选鉴定出PTPN21和WDR26作为线粒体应激诱导的ISR调节因子
Wen Li,Mingyue Dong,Kaiyu Gao et al.
Wen Li et al.
MRE11 lactylation: a linker between Warburg effect and DNA repair [0.03%]
MRE11 乳酰化：连接瓦博格效应和DNA修复的纽带
Pingyu Liu,Hongbin Ji,Fuming Li
Pingyu Liu
Zhi-Tian Chen,Zhi-Xuan Weng,Jiandie D Lin et al.
Zhi-Tian Chen et al.
Skeletal muscle plays a vital role in the regulation of systemic metabolism, partly through its secretion of endocrine factors which are collectively known as myokines. Altered myokine levels are associated with metabolic diseases, such as ...
Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in Apoe-/- mice [0.03%]
间歇性断食通过抑制阿帕波缺陷小鼠肝脏ATF3表达加重动脉粥样硬化病情
Yajuan Deng,Xiaoyu Yang,Xueru Ye et al.
Yajuan Deng et al.
Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Alternate day fasting (ADF) has gained growing attention due to its metabolic benefits. However, the effects of ADF on atherosclerotic plaque formation remain i...
John R Speakman
John R Speakman