Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway [0.03%]
通过LPE-PPARγ-NF-κB-CCL5途径阻断Arf1介导的癌症脂质代谢可促进细胞毒性T淋巴细胞浸润肿瘤组织
Na Wang,Tiange Yao,Chenfei Luo et al.
Na Wang et al.
Tumor immunotherapy has achieved breakthroughs in a variety of tumors. However, the systemic absence of T cells in tumors and immunosuppressive tumor microenvironment so far limits the efficacy of immunotherapy to a small population of pati...
Ping-Chih Ho,Chenqi Xu,Tiffany Horng
Ping-Chih Ho
Guang Lu,Han-Ming Shen
Guang Lu
You are what you eat: feeding neurons in nutrient regulation of behavior [0.03%]
吃出性格来：营养调控行为中的神经元供养问题探究
Jessie C Morrill,Qingchun Tong
Jessie C Morrill
Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons [0.03%]
精氨酸加压素神经元中的GCN2介导的亮氨酸剥夺具有抗抑郁作用
Feixiang Yuan,Shangming Wu,Ziheng Zhou et al.
Feixiang Yuan et al.
Essential amino acids (EAAs) are crucial nutrients, whose levels change in rodents and patients with depression. However, how the levels of a single EAA affects depressive behaviors remains elusive. Here, we demonstrate that although depriv...
Xuelian Xiong,Xiaoying Li
Xuelian Xiong
Both non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are highly prevalent metabolic liver diseases. Accumulating epidemiological evidence now indicates that NAFLD and T2DM are strongly associated, yet the causa...
Wei Jia,Xiaojiao Zheng
Wei Jia
Cigarette smoking is considered a risk factor for nonalcoholic fatty liver disease (NAFLD). In a study recently published in Nature, Chen et al. unveiled a mechanistic role of nicotine in NAFLD progression. In addition, they identified a gu...
Callen C Goldsmith,Garron T Dodd
Callen C Goldsmith
Zhongsheng Wu,Yongtao Du,Tom Kirchhausen et al.
Zhongsheng Wu et al.
Distinct phospholipid species display specific distribution patterns across cellular membranes, which are important for their structural and signaling roles and for preserving the integrity and functionality of the plasma membrane and organ...
BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer [0.03%]
BET抑制通过GDH1依赖性谷氨酰胺代谢重组诱导肝癌细胞的脆弱性
Wen Mi,Jianwei You,Liucheng Li et al.
Wen Mi et al.
Bromodomain and extra-terminal domain (BET) proteins, which function partly through MYC proto-oncogene (MYC), are critical epigenetic readers and emerging therapeutic targets in cancer. Whether and how BET inhibition simultaneously induces ...