CLPTM1L modulates membrane lipid rafts to promote tumor EGFR signaling [0.03%]
CLPTM1L调节细胞膜脂筏促进肿瘤EGFR信号转导
Dejian Pang,Xuan Yang,Xinyao Li et al.
Dejian Pang et al.
The plasma membrane dynamically organizes into specialized lipid domains to sustain cell proliferative signaling, yet the regu-latory mechanisms driving this process, especially during tumor progression, remain poorly understood. Here, we u...
Life Metabolism Editorial Team
Life Metabolism Editorial Team
Tong Li,Ying Jin,Sikang Ren et al.
Tong Li et al.
Graphical AbstractFor image description, please refer to the figure legend and surrounding text. © The Author(s) 2026. Published by Oxford University Pr...
Sphingolipid homeostasis and dysregulation in liver function and disease [0.03%]
鞘脂稳态及其失衡在肝功能和疾病中的作用
Jianfeng Lan,Zhixiong Pan,Wei Dong et al.
Jianfeng Lan et al.
Sphingolipids regulate hepatic lipid homeostasis, cell survival, inflammation, and tissue repair. In the healthy liver, balanced de novo sphingolipid synthesis, salvage pathways, and sphingosine-1-phosphate (S1P)-related signals maintain me...
Intestinal epithelial formyl peptide receptor 2 contributes to intestinal epithelium homeostasis and injury repair by regulating intestinal stem cell and transit-amplifying cell proliferation and differentiation [0.03%]
肠上皮形式肽受体2通过调节肠道干细胞和扩增细胞的增殖和分化来促进肠上皮稳态和损伤修复
Shuting Yu,Lele Song,Wunier et al.
Shuting Yu et al.
Intestinal stem cells (ISCs) play critical roles in the self-renewal and regeneration of the intestinal epithelium under physiological conditions and after injury, respectively. However, the underlying mechanisms are not fully understood. I...
Lysosomes contribute to the synthesis of tricarboxylic acid-related metabolites in the hippocampus [0.03%]
溶酶体参与海马区三羧酸相关代谢物的合成
Liangliang Kong,Hongying Tan,Xiaoting Zhu et al.
Liangliang Kong et al.
The central nervous system is highly sensitive to energy supply, and the hippocampus operates under sustained metabolic load due to continuous synaptic activity and information processing. Lysosomes couple nutrient status to cellular energe...
Zhihui Zhang,John A Hawley,Min-Dian Li
Zhihui Zhang
Exercise performance in endurance- and power-based events is time-of-day dependent in both humans and rodents. Accordingly, there has been growing interest in determining whether there is an optimal time of day for physical activity that ca...
Age-specific effects of hemoglobin A1c, blood pressure, and cholesterol levels on incident cardiovascular diseases among adults with diabetes in China: a 10-year prospective cohort study [0.03%]
中国成人糖尿病患者心血管疾病发病的危险因素及年龄效应：一项为期十年的队列研究
Yue Yin,Xiaojing Jia,Shengli Wu et al.
Yue Yin et al.
Optimal control of hemoglobin A1c (HbA1c), blood pressure, and cholesterol (ABC risk factors) is essential for reducing cardiovascular disease (CVD) risk in individuals with diabetes. However, age-specific contributions of these factors rem...
Integrative omics analysis incorporating cardiovascular magnetic resonance imaging pinpoints potentially druggable plasma proteins for cardiovascular diseases [0.03%]
整合心血管磁共振成像的集成组学分析锁定心血管疾病的潜在可药物化血浆蛋白
Weiming Gong,Ping Guo,Lu Liu et al.
Weiming Gong et al.
Despite advances in traditional risk factors for cardiovascular diseases (CVDs), significant residual risk of CVDs remains incompletely captured. Integrative analysis incorporating cardiovascular magnetic resonance imaging (CMR) could facil...
John R Speakman,Sharon E Mitchell
John R Speakman
Calorie restriction (CR) is a nutritional intervention known to delay aging and extend lifespan across a wide range of species, raising the possibility of similar benefits in humans. This apparent universality has been questioned by studies...