The relationship between schizophrenia polygenic scores, blood-based proteins and psychosis diagnosis in the UK Biobank [0.03%]
英国生物样本库中精神分裂症多基因评分、血液蛋白与精神病诊断之间的关系
Kimberley M Kendall,Sophie E Legge,Eilidh Fenner et al.
Kimberley M Kendall et al.
Despite notable progress in psychiatric genomics, there are no validated blood-based biomarkers for psychosis. Previous studies have failed to establish a link between schizophrenia polygenic scores (PGS) and blood protein levels. We aimed ...
Social cognitive deficits and their relationship with clinical symptoms in schizophrenia [0.03%]
精神分裂症的社会认知缺陷及其与临床症状的关系研究
Danni He,Douyu Zhang,Yushen Ding et al.
Danni He et al.
While individuals with schizophrenia (SZ) exhibit deficits in social cognition, the specific profile of these deficits across multiple domains and their relationship with clinical symptoms warrants further characterization. This study aimed...
Gender differences in semantic facilitation and verbal recall in schizotypal personality disorder [0.03%]
分裂型人格障碍中的语义启动及言语回忆的性别差异
Martina M Voglmaier,Chandlee C Dickey,Robert W McCarley et al.
Martina M Voglmaier et al.
Previous studies have found that individuals with schizophrenia (SZ) benefit less from semantic context in verbal recall than comparison (HC) subjects. This has not been systematically studied in individuals with schizotypal personality dis...
Cognitive and emotional effects of bilateral prefrontal anodal tDCS and high-frequency tRNS in schizophrenia: a randomized sham-controlled study [0.03%]
经颅直流电刺激和经颅随机噪声刺激对精神分裂症患者认知和情感影响的对比研究：一项随机对照试验
Eisa Jafari,Ali Moghadamzadeh,Zahra Vaziri et al.
Eisa Jafari et al.
Cognitive deficits in schizophrenia significantly hinder functional outcomes and often remain unresponsive to conventional treatments. While initial evidence suggested potential pro-cognitive effects of electrical brain stimulation in schiz...
Altered neural processing in middle frontal gyrus and cerebellum during temporal recalibration of action-outcome predictions in schizophrenia spectrum disorders [0.03%]
精神分裂症谱系障碍患者在动作-结果预测时间校准时额中回和小脑神经元处理异常
Christina V Schmitter,Benjamin Straube
Christina V Schmitter
A key function of the perceptual system is to predict the (multi)sensory outcomes of actions and recalibrate these predictions in response to changing conditions. In schizophrenia spectrum disorders (SSD), impairments in this ability have b...
Post-mortem brain analysis reveals altered monoaminergic system in the dorsolateral prefrontal cortex and hippocampus in chronic schizophrenia [0.03%]
尸检脑分析发现单胺系统在慢性精神分裂症的大脑背外侧前额皮质和海马区的改变
Anna Di Maio,Valentina Bassareo,Giuseppe De Simone et al.
Anna Di Maio et al.
Schizophrenia is a multifactorial psychiatric disorder in which monoaminergic neurotransmission, particularly dopamine (DA), serotonin (5-HT), and norepinephrine (NE), is implicated in both pathophysiology and response to treatments. Howeve...
Abnormal plasma oxidative stress markers in first-episode schizophrenia and associations with clinical symptoms and cognitive function [0.03%]
首发精神分裂症患者的异常氧化应激标记物及其与临床症状和认知功能的关系
Fei Jiang,Tingting Jin,Qun Yang et al.
Fei Jiang et al.
Accumulating evidence suggests that oxidative stress (OS) contributes to the onset and progression of schizophrenia (SCZ). However, the pattern of OS alterations in first-episode, drug-naïve patients and their associations with clinical an...
Risperidone reduces individualized morphometric similarity deviation in schizophrenia and associates with cortical transcriptomic patterns [0.03%]
利培酮可减少精神分裂症患者的个体化形态学相似性偏差并影响皮层转录组模式
Liju Liu,Mi Yang,Jinxing Chen et al.
Liju Liu et al.
Schizophrenia has been linked to reduced cortical thickness and abnormal gene expression. While antipsychotic treatment has been found to affect cortical morphology and gene expression, its impact on subject-specific deviations in cortical ...
Whole-brain functional connectivity predicts ultra-high risk for psychosis status and level of functioning [0.03%]
全脑功能连接预测极高精神病风险状态及功能水平
Karen S Ambrosen,Tina D Kristensen,Louise B Glenthøj et al.
Karen S Ambrosen et al.
Resting-state functional magnetic resonance imaging (rs-fMRI) has offered insights into the neural mechanisms underlying psychosis, particularly when associated with clinically relevant features. 102 individuals at ultra-high risk for psych...
Peripheral inflammation mediates cognitive deficits in drug-naive schizophrenia through hippocampal-thalamo-visual circuitry dysfunction [0.03%]
外周炎症通过海马-丘脑-视觉环路功能障碍介导药物未治疗的精神分裂症患者的认知缺陷
Ningzhi Gou,Qingyan Ma,Min Jia et al.
Ningzhi Gou et al.
Converging evidence indicates that dysregulated cortico-subcortical connectivity underpins core cognitive impairment in schizophrenia (SCZ). However, the mechanistic basis linking this disrupted brain function to cognitive deficits remains ...