Is emotion regulation a mechanism of change in virtual reality-assisted therapy for auditory hallucinations? Secondary analyses of the CHALLENGE randomized clinical trial [0.03%]
虚拟现实辅助治疗听觉幻觉的情绪调节机制？来自CHALLENGE随机对照试验的次级分析
Louise Birkedal Glenthøj,Ditte Lammers Vernal,Lise Sandvig Mariegaard et al.
Louise Birkedal Glenthøj et al.
Virtual reality (VR)-assisted avatar therapy has shown promising effects for reducing voice-related distress and overall severity of persistent auditory verbal hallucinations (AVH) in psychosis, yet the mechanisms underlying these improveme...
Decoding neurodevelopmental changes in schizophrenia: a comprehensive systematic review of neurogenic alterations [0.03%]
精神分裂症神经发育变化的解码：神经生成改变的全面系统回顾
Noemí Rueda,Ana Gómez-Garrido,María Alemany-Navarro et al.
Noemí Rueda et al.
Schizophrenia (SCZ) is a chronic brain disorder with significant impacts on patients, families, and society, affecting health, social life, and economic well-being. Despite extensive research, the biological basis of SCZ remains unclear. Ho...
A new mechanism underlying mitochondrial dysfunction in schizophrenia - attenuated mRNA transport of the complex I subunit NDUFV2 by its pseudogene NDUFV2P1 [0.03%]
精神分裂症中线粒体功能障碍的新机制-复合物I亚基NDUFV2的mRNA转运受到其假基因NDUFV2P1抑制
Rachel Karry,Dorit Ben-Shachar
Rachel Karry
While schizophrenia (SZ) etiology remains unclear, accumulating evidence implicates mitochondrial dysfunction, particularly complex-I of the respiratory chain and its essential free-electron scavenger subunit, NDUFV2, as a contributor to ne...
Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis [0.03%]
首次精神病发作且未使用抗精神病药物患者的认知亚型及大脑网络差异
Hillary N Patton,Jose O Maximo,Lauren Luther et al.
Hillary N Patton et al.
Cognitive functioning within psychosis is heterogeneous, and data-driven approaches may help evaluate this heterogeneity. Brain network connectivity within first-episode psychosis (FEP) may provide an additional tool for understanding cogni...
Pharmacological treatment of schizophrenia: Japanese Expert Consensus 2025 [0.03%]
2025年日本抗精神病药物治疗专家共识
Yoshiteru Takekita,Hideaki Tani,Yasushi Kawamata et al.
Yoshiteru Takekita et al.
Conventional schizophrenia treatment guidelines do not adequately address all clinically important issues in routine practice. This study aimed to update the 2021 expert consensus of the Japanese Society of Clinical Neuropsychopharmacology ...
Jason Jepson
Jason Jepson
Facial expressions and emotional experience during social interaction in autism and schizophrenia [0.03%]
自闭症和分裂症患者在社交互动中面部表情与情感体验的关系
Vladimír Ivančík,Natália Čavojská,Alexandra Straková et al.
Vladimír Ivančík et al.
Blunted affect is a transdiagnostic feature that impairs social functioning across psychiatric conditions, including schizophrenia and autism. We quantified facial expression patterns and subjective emotional experience during standardized ...
Joshua Chiappelli,Hongji Chen,Stephanie A Korenic et al.
Joshua Chiappelli et al.
Brain macromolecule signals detected with proton magnetic resonance spectroscopy (MRS) are often regarded as a nuisance, but may be potential markers of pathophysiological processes, such as inflammation, impaired glymphatic clearance, and ...
The role of fear learning in the development of psychosis: an EEG study utilizing a differential fear conditioning paradigm in people with psychotic vulnerability [0.03%]
恐惧学习在精神病发病机制中的作用：一种利用差异性恐惧条件反射范式的EEG研究及其在易感人群中的应用
Metin Özyagcilar,Nilay Esin Ahrens-Demirdal,Anja Riesel et al.
Metin Özyagcilar et al.
By studying how individuals in an "at-risk" state of psychosis learn about threat and safety cues - specifically, how they develop and unlearn fear responses to neutral cues - we might better understand the mechanisms leading to heightened ...
Integrated alterations in inflammation, endothelial function, and extracellular matrix pathways in first-episode drug-naïve schizophrenia [0.03%]
首次发作未经治疗的精神分裂症患者中炎症、内皮功能和细胞外基质通路的整合改变
Qun Yang,Xiaoyu Sun,Sichang Jin et al.
Qun Yang et al.
Objective peripheral biomarkers for early-stage schizophrenia are needed to improve diagnostic accuracy and treatment planning. To identify potential biomarkers, we compared multiple serum factor concentrations between 90 first-episode drug...