Using smartphone-based assessment of social experience to predict relapse in first-episode psychosis [0.03%]
基于智能手机的社会体验评估在首发精神病复发中的预测作用
Ryan Hammoud,Anna Georgiades,Maria Chiara Del Piccolo et al.
Ryan Hammoud et al.
Social-affective changes are early indicators of psychosis relapse, yet their dynamic and subjective nature makes them difficult to capture between routine clinical assessments. Smartphone-based ecological assessments offer a method for cap...
Discriminative validity of Clinical High-Risk Status for Psychosis among help-seekers: a systematic review and meta-analysis [0.03%]
系统综述与元分析：求助者精神病高风险状态的判别效度
Andrea Raballo,Antonio Preti,Michele Poletti
Andrea Raballo
The Clinical High-Risk for Psychosis (CHR-P) paradigm underpins early detection strategies and informs the DSM-5 construct of Attenuated Psychosis Syndrome (APS), yet its discriminative predictive validity relative to CHR-P-negative help-se...
Disrupted cerebellar interactions in the cerebellar-thalamo-cortical triple network model across risk states and first-episode psychosis [0.03%]
风险状态和首次发作的精神分裂症患者小脑-丘脑-皮层三重网络模型中小脑相互作用的破坏
Minji Ha,Inkyung Park,Hyungyou Park et al.
Minji Ha et al.
Cerebellar dysconnectivity has been repeatedly linked to psychosis and is often accompanied by disruptions in thalamic and cortical regions. These disturbances are broadly consistent with the triple network model, which conceptualizes psych...
Real-world treatment patterns, healthcare resource utilization and economic burden in U.S. adults with schizophrenia with and without tardive dyskinesia [0.03%]
美国成人精神分裂症患者伴与不伴迟发性运动障碍的治疗模式、医疗资源利用和经济负担：基于真实世界的研究
Rashmi Patel,Doyoung Kim,Weihua Gao et al.
Rashmi Patel et al.
Tardive dyskinesia (TD) is a persistent, iatrogenic movement disorder arising from long-term use of dopamine receptor antagonists, particularly antipsychotics; however, its clinical and economic impact among adults with schizophrenia remain...
East Asian herbal medicine as an adjunctive treatment for schizophrenia: a systematic review and meta-analysis [0.03%]
中药作为精神分裂症的辅助治疗：系统评价和荟萃分析
Yujin Choi,Pyung-Wha Kim,Chan-Young Kwon et al.
Yujin Choi et al.
Background: Herbal medicine is widely used as an adjunctive treatment for schizophrenia, but evidence remains limited. Aims: To evaluat...
Glutathione-related redox imbalance and cognitive impairment in drug-naïve, first-episode schizophrenia: a focus on GSSG [0.03%]
初发未服药精神分裂症患者谷胱甘肽相关氧化还原失衡及认知损害：对GSSG的关注
Fei Jiang,Qing Tian,Lulu Xu et al.
Fei Jiang et al.
Cognitive impairment is a core feature of schizophrenia, yet the biological basis has not been established. Redox dysregulation has been implicated in cognitive impairment of patients with schizophrenia but evidence in early-stage, drug-na...
Shared genetic architecture between schizophrenia and subcortical brain susceptibility phenotypes [0.03%]
精神分裂症与皮质下脑易感性表型之间的共享遗传结构
Yingying Xie,Jiaojiao Du,Yao Zhao et al.
Yingying Xie et al.
Schizophrenia (SCZ) is a highly heritable and complex neuropsychiatric disorder. Emerging evidence implicates dysregulated brain iron, particularly in subcortical regions, in SCZ pathophysiology. Here, we systematically dissected the shared...
Annika Resch,Alexander N Sokolov,Patrick Steinwand et al.
Annika Resch et al.
Neurotypical people are generally quite adept at interpreting social signals from dynamic bodies and faces. This ability prevents one from incurring high costs associated with ineffective and maladaptive social interactions. Individuals wit...
Unveiling the molecular mechanisms of clozapine-induced seizures: a network pharmacology and molecular docking-based investigation [0.03%]
基于网络药理学和分子对接的氯氮平致癫痫的分子机制研究
Daxiang Lian,Jian Li,Bo Han et al.
Daxiang Lian et al.
Clozapine is the preferred treatment for refractory schizophrenia. However, clozapine use is constrained by the risk of clozapine‑induced seizures (CISs). The molecular mechanisms behind CISs are complex and poorly understood. The objectiv...
Stressful life events and their association with symptom severity and functioning in first-episode psychosis [0.03%]
首次精神病发作患者的应激生活事件与症状严重程度及社会功能损害的关系研究
Stefania Tognin,Mariia Moroz,Aljawharah Almuqrin et al.
Stefania Tognin et al.
Stressful life events (SLEs) are a risk factor for psychosis; however, evidence on the impact of SLEs in individuals with first-episode psychosis (FEP) is limited. The current study draws on longitudinal data from the social mind study (ISR...