Non-pharmacological interventions for schizophrenia-analysis of treatment guidelines and implementation in 12 Southeast European countries [0.03%]
非药物治疗精神分裂症：来自东南欧12个国家的治疗指南分析及实施状况调查
Lidija Injac Stevović,Selman Repišti,Tamara Radojičić et al.
Lidija Injac Stevović et al.
This study aimed to analyze treatment guidelines of 12 SEE countries to identify non-pharmacological interventions recommended for schizophrenia, explore the evidence base supporting recommendations, and assess the implementation of recomme...
Association between olanzapine concentration and metabolic dysfunction in drug-naive and chronic patients: similarities and differences [0.03%]
利培酮浓度与药物治疗初诊和慢性患者代谢功能障碍的关系：相同点和不同点
Dongyu Kang,Jinjun Lu,Wenqing Liu et al.
Dongyu Kang et al.
Second-generation antipsychotics are widely used to treat schizophrenia but their use could induce metabolic dysfunction. To balance efficacy and side effects, various guidelines recommend the use of therapeutic drug monitoring. Given the c...
Reduced erythrocyte membrane polyunsaturated fatty acid levels indicate diminished treatment response in patients with multi- versus first-episode schizophrenia [0.03%]
血红细胞膜多不饱和脂肪酸水平降低提示首发与多重发作精神分裂症患者治疗反应差异
Nana Li,Ping Yang,Mimi Tang et al.
Nana Li et al.
Antipsychotic effects seem to decrease in relapsed schizophrenia patients and the underlying mechanisms remain to be elucidated. Based on the essential role of polyunsaturated fatty acids in brain function and the treatment of schizophrenia...
Deep rTMS of the insula and prefrontal cortex in smokers with schizophrenia: Proof-of-concept study [0.03%]
针对精神分裂症吸烟者的深部rTMS背侧前额叶和insula皮层概念验证研究
Scott J Moeller,Roberto Gil,Jodi J Weinstein et al.
Scott J Moeller et al.
Patients with schizophrenia have a high prevalence of cigarette smoking and respond poorly to conventional treatments, highlighting the need for new therapies. We conducted a mechanistic, proof-of-concept study using bilateral deep repetiti...
Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain [0.03%]
机器学习算法揭示了一种谷氨酸能神经元在精神分裂症死者大脑中的变化
Arianna De Rosa,Andrea Fontana,Tommaso Nuzzo et al.
Arianna De Rosa et al.
Schizophrenia is a disorder of synaptic plasticity and aberrant connectivity in which a major dysfunction in glutamate synapse has been suggested. However, a multi-level approach tackling diverse clusters of interacting molecules of the glu...
Author Correction: Persons with first episode psychosis have distinct profiles of social cognition and metacognition [0.03%]
作者更正：首发精神病患者具有不同的社会认知和元认知特征
M Ferrer-Quintero,D Fernández,R López-Carrilero et al.
M Ferrer-Quintero et al.
Published Erratum
Schizophrenia (Heidelberg, Germany). 2022 Feb 24;8(1):3. DOI:10.1038/s41537-021-00199-4 2022
Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia [0.03%]
重复经颅磁刺激对精神分裂症患者大麻使用和认知的影响研究
Karolina Kozak Bidzinski,Darby J E Lowe,Marcos Sanches et al.
Karolina Kozak Bidzinski et al.
Cannabis use disorder (CUD) occurs at high rates in schizophrenia, which negatively impacts its clinical prognosis. These patients have greater difficulty quitting cannabis which may reflect putative deficits in the dorsolateral prefrontal ...
Development and validation of a web-based prediction tool on minor physical anomalies for schizophrenia [0.03%]
开发和验证用于预测精神分裂症的轻度身体异常的网络工具及其效度研究
Xin-Yu Wang,Jin-Jia Lin,Ming-Kun Lu et al.
Xin-Yu Wang et al.
In support of the neurodevelopmental model of schizophrenia, minor physical anomalies (MPAs) have been suggested as biomarkers and potential pathophysiological significance for schizophrenia. However, an integrated, clinically useful tool t...
Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics [0.03%]
系统综述精神分裂症临床实践指南中的急性期和维持期抗精神病药物治疗规范
Christoph U Correll,Amber Martin,Charmi Patel et al.
Christoph U Correll et al.
Clinical practice guidelines (CPGs) translate evidence into recommendations to improve patient care and outcomes. To provide an overview of schizophrenia CPGs, we conducted a systematic literature review of English-language CPGs and synthes...
Identifying schizophrenia stigma on Twitter: a proof of principle model using service user supervised machine learning [0.03%]
基于服务对象监督的机器学习在推特上鉴别精神分裂症患者的病耻感：一个概念验证模型
Sagar Jilka,Clarissa Mary Odoi,Janet van Bilsen et al.
Sagar Jilka et al.
Stigma has negative effects on people with mental health problems by making them less likely to seek help. We develop a proof of principle service user supervised machine learning pipeline to identify stigmatising tweets reliably and unders...