Adult stress exposure blunts dopamine system hyperresponsivity in a neurodevelopmental rodent model of schizophrenia [0.03%]
成年期压力暴露减弱了神经发育性啮齿动物精神分裂症模型中的多巴胺系统过度反应现象
Millie Rincón-Cortés,Anthony A Grace
Millie Rincón-Cortés
Stress is a major risk factor for the development of both schizophrenia and depression, and comorbidity between the two is common in schizoaffective disorders. However, the effects of stress exposure (i.e. chronic mild stress-CMS) on depres...
Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study [0.03%]
情感唤起失调调节精神分裂症患者的奖赏决策：整合研究
Hong-Hsiang Liu,Chih-Min Liu,Ming H Hsieh et al.
Hong-Hsiang Liu et al.
Schizophrenia is a chronic and severe mental disorder. Dysregulated decision-making and affective processing have been implicated in patients with schizophrenia (SZ) and have significant impacts on their cognitive and social functions. Howe...
Early-stage visual perception impairment in schizophrenia, bottom-up and back again [0.03%]
精神分裂症早期视觉感知障碍：从初级感觉信息处理到皮层高级区域的往返之旅
Petr Adámek,Veronika Langová,Jiří Horáček
Petr Adámek
Visual perception is one of the basic tools for exploring the world. However, in schizophrenia, this modality is disrupted. So far, there has been no clear answer as to whether the disruption occurs primarily within the brain or in the prec...
Early visual processing and adaptation as markers of disease, not vulnerability: EEG evidence from 22q11.2 deletion syndrome, a population at high risk for schizophrenia [0.03%]
早期视觉处理和适应作为疾病的标志，而不是脆弱性的标志：来自22q11.2缺失综合征的EEG证据，该综合症是高风险精神分裂症群体
Ana A Francisco,John J Foxe,Douwe J Horsthuis et al.
Ana A Francisco et al.
We investigated visual processing and adaptation in 22q11.2 deletion syndrome (22q11.2DS), a condition characterized by an increased risk for schizophrenia. Visual processing differences have been described in schizophrenia but remain under...
Prediction of quality of life in schizophrenia using machine learning models on data from Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial [0.03%]
利用机器学习模型预测临床抗精神病药物有效性试验（CATIE）精神分裂症试验的数据中的生活质量
Mélissa Beaudoin,Alexandre Hudon,Charles-Edouard Giguère et al.
Mélissa Beaudoin et al.
While research focus remains mainly on psychotic symptoms, it is questionable whether we are placing enough emphasis on improving the quality of life (QoL) of schizophrenia patients. To date, the predictive power of QoL remained limited. Th...
A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia [0.03%]
慢性精神分裂症患者身体脂肪体积和分布的横断面磁共振研究
Emanuele F Osimo,Stefan P Brugger,E Louise Thomas et al.
Emanuele F Osimo et al.
People with schizophrenia show higher risk for abdominal obesity than the general population, which could contribute to excess mortality. However, it is unclear whether this is driven by alterations in abdominal fat partitioning. Here, we t...
Michael Murphy,Dost Öngür
Michael Murphy
Thought disorder may be associated with subtle language abnormalities. Binomials are pairs of words of the same grammatical type that are joined by a conjunction that often have a preferred order (for example, "up and down" is more common t...
Does temporal irregularity drive prediction failure in schizophrenia? temporal modelling of ERPs [0.03%]
精神分裂症预测失败由时间不规则性引起吗？事件相关电位的时间模式化
Maria Karanikolaou,Jakub Limanowski,Georg Northoff
Maria Karanikolaou
Schizophrenia subjects often suffer from a failure to properly predict incoming inputs; most notably, some patients exhibit impaired prediction of the sensory consequences of their own actions. The mechanisms underlying this deficit remain ...
Facing the pandemic and lockdown: an insight on mental health from a longitudinal study using diaries [0.03%]
面对疫情和封锁：一项使用日记进行的纵向研究对精神健康洞察的看法
Amaury C Mengin,Melissa C Allé,Estelle Koning et al.
Amaury C Mengin et al.
We conducted a longitudinal online study to examine attenuated psychotic symptoms (APS) over time in a sample of locked-down individuals. We used (i) questionnaires and (ii) the automatic analysis of the emotional content of narratives. Par...
Distinctive pattern of neutrophil count change in clozapine-associated, life-threatening agranulocytosis [0.03%]
与氯氮平相关危及生命的粒细胞缺乏症的中性粒细胞计数变化特征模式
David Taylor,Kalliopi Vallianatou,Eromona Whiskey et al.
David Taylor et al.
The wider use of clozapine is limited by the risk of agranulocytosis and the associated requirement for monitoring of neutrophil counts. We searched local electronic patient records for cases of agranulocytosis occurring during clozapine tr...