Cognitive and emotional effects of bilateral prefrontal anodal tDCS and high-frequency tRNS in schizophrenia: a randomized sham-controlled study [0.03%]
经颅直流电刺激和经颅随机噪声刺激对精神分裂症患者认知和情感影响的对比研究：一项随机对照试验
Eisa Jafari,Ali Moghadamzadeh,Zahra Vaziri et al.
Eisa Jafari et al.
Cognitive deficits in schizophrenia significantly hinder functional outcomes and often remain unresponsive to conventional treatments. While initial evidence suggested potential pro-cognitive effects of electrical brain stimulation in schiz...
Altered neural processing in middle frontal gyrus and cerebellum during temporal recalibration of action-outcome predictions in schizophrenia spectrum disorders [0.03%]
精神分裂症谱系障碍患者在动作-结果预测时间校准时额中回和小脑神经元处理异常
Christina V Schmitter,Benjamin Straube
Christina V Schmitter
A key function of the perceptual system is to predict the (multi)sensory outcomes of actions and recalibrate these predictions in response to changing conditions. In schizophrenia spectrum disorders (SSD), impairments in this ability have b...
Post-mortem brain analysis reveals altered monoaminergic system in the dorsolateral prefrontal cortex and hippocampus in chronic schizophrenia [0.03%]
尸检脑分析发现单胺系统在慢性精神分裂症的大脑背外侧前额皮质和海马区的改变
Anna Di Maio,Valentina Bassareo,Giuseppe De Simone et al.
Anna Di Maio et al.
Schizophrenia is a multifactorial psychiatric disorder in which monoaminergic neurotransmission, particularly dopamine (DA), serotonin (5-HT), and norepinephrine (NE), is implicated in both pathophysiology and response to treatments. Howeve...
Abnormal plasma oxidative stress markers in first-episode schizophrenia and associations with clinical symptoms and cognitive function [0.03%]
首发精神分裂症患者的异常氧化应激标记物及其与临床症状和认知功能的关系
Fei Jiang,Tingting Jin,Qun Yang et al.
Fei Jiang et al.
Accumulating evidence suggests that oxidative stress (OS) contributes to the onset and progression of schizophrenia (SCZ). However, the pattern of OS alterations in first-episode, drug-naïve patients and their associations with clinical an...
Risperidone reduces individualized morphometric similarity deviation in schizophrenia and associates with cortical transcriptomic patterns [0.03%]
利培酮可减少精神分裂症患者的个体化形态学相似性偏差并影响皮层转录组模式
Liju Liu,Mi Yang,Jinxing Chen et al.
Liju Liu et al.
Schizophrenia has been linked to reduced cortical thickness and abnormal gene expression. While antipsychotic treatment has been found to affect cortical morphology and gene expression, its impact on subject-specific deviations in cortical ...
Whole-brain functional connectivity predicts ultra-high risk for psychosis status and level of functioning [0.03%]
全脑功能连接预测极高精神病风险状态及功能水平
Karen S Ambrosen,Tina D Kristensen,Louise B Glenthøj et al.
Karen S Ambrosen et al.
Resting-state functional magnetic resonance imaging (rs-fMRI) has offered insights into the neural mechanisms underlying psychosis, particularly when associated with clinically relevant features. 102 individuals at ultra-high risk for psych...
Peripheral inflammation mediates cognitive deficits in drug-naive schizophrenia through hippocampal-thalamo-visual circuitry dysfunction [0.03%]
外周炎症通过海马-丘脑-视觉环路功能障碍介导药物未治疗的精神分裂症患者的认知缺陷
Ningzhi Gou,Qingyan Ma,Min Jia et al.
Ningzhi Gou et al.
Converging evidence indicates that dysregulated cortico-subcortical connectivity underpins core cognitive impairment in schizophrenia (SCZ). However, the mechanistic basis linking this disrupted brain function to cognitive deficits remains ...
Associations between second-generation antipsychotics and metabolic outcomes in patients with schizophrenia and metabolic abnormalities [0.03%]
代谢异常的精神分裂症患者使用第二代抗精神病药物与代谢结局之间的关系
Zhengluan Liao,Yaguan Zhou,Junjie Lin et al.
Zhengluan Liao et al.
Second-generation antipsychotics (SGAs) were found to have varying metabolic side-effects for patients with schizophrenia, while no studies have examined the associations between adding or switching low-risk SGAs and metabolic outcomes. Thi...
Neurobiological illness models of schizophrenia and stigma reduction: has that ship sailed? [0.03%]
精神分裂症的神经生物学疾病模型与减少病耻感：这个机会错过了吗？
Philipp Sterzer,Nicolai Rohner,Christian Huber
Philipp Sterzer
Stigma substantially contributes to the burden of psychotic disorders such as schizophrenia. Previous attempts to reduce stigma based on neurobiological illness models were unsuccessful. In this Perspective article, we argue that these mode...
Polygenic risk for schizophrenia is associated with white matter microstructure, cognitive and mental health [0.03%]
精神分裂症的多基因风险与神经白质微结构、认知和心理健康相关
Qian Qian,Guoshu Zhao,Nannan Zhang et al.
Qian Qian et al.
Schizophrenia is highly heritable, and polygenic risk score for schizophrenia (PRSSCZ) has been associated with brain and behavior in healthy populations. However, the full associations of PRSSCZ with brain white matter microstructure and c...