Changes of psychological and biological stress parameters in individuals with schizophrenia spectrum disorders participating in a mindfulness-based group therapy [0.03%]
精神分裂症谱系障碍患者参与基于正念群体治疗的心理和生物应激指标变化
Marco Zierhut,Sarah Koop,Niklas Bergmann et al.
Marco Zierhut et al.
This study investigates changes in stress parameters in individuals with schizophrenia spectrum disorders participating in mindfulness-based group therapy (MBGT). N = 45 participants were randomised to MBGT or Treatment as Usual over four w...
Blood levels of D-aspartate oxidase, D-amino acid oxidase, serine racemase, and pLG72 are influenced by diagnoses of schizophrenia and autism spectrum disorder [0.03%]
多巴胺能神经递质代谢酶和蛋白的血液水平受精神分裂症和自闭症影响
Elisa Maffioli,Francesco Errico,Zoraide Motta et al.
Elisa Maffioli et al.
Free D-serine (D-Ser) and D-aspartate (D-Asp) are increasingly recognized as key modulators of glutamatergic NMDA receptor-dependent neurotransmission, whose dysfunction has been implicated in neuropsychiatric conditions, including schizoph...
Relating latent factors of reasoning, affect, and cognition to the delusional experience [0.03%]
推理、情绪和认知的潜在因素与妄想体验的关系
Annalise Halverson,Andrew R Kittleson,Jinyuan Liu et al.
Annalise Halverson et al.
Reasoning biases play a crucial role in the formation and maintenance of delusions. In psychosis, it is unclear whether these biases cluster onto similar underlying factors or represent independent constructs. The current study presents dat...
A new approach for understanding the association between chronic stress in childhood and psychotic symptoms in schizophrenia patients from mediating role of lncRNA [0.03%]
从长链非编码RNA介导作用角度理解儿童期慢性压力与精神分裂症患者精神病性症状关联的新方法
Zhiyong Mi,Yan Yan,Lingming Kong
Zhiyong Mi
Schizophrenia (SCZ) remains an etiological and therapeutic challenge, this article aims to explore the mediating role of lncRNA between chronic childhood stress and SCZ for providing a scientific basis of SCZ prevention. 200 SCZ patients an...
From neuroinflammation to neural inference: computational psychiatry meets precision medicine [0.03%]
从神经炎症到神经推断：计算精神病学与精准医学的结合
Ghaith K Mansour,Ahmad W Hajjar
Ghaith K Mansour
Psychosis spectrum disorders exhibit substantial clinical variability, necessitating novel frameworks that transcend traditional symptomatic classification. While polygenic risk accounts for significant heritability, the precise mechanisms ...
Helene Speyer,Marte Ustrup,Mette Ødegaard
Helene Speyer
Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis [0.03%]
早期精神病患者的社会大脑网络休息态功能连接与阴性症状之间的关联研究
Anna R Knippenberg,Lawrence H Sweet,Lauren Luther et al.
Anna R Knippenberg et al.
Negative symptoms of psychotic disorders are best represented within a hierarchical structure comprising two broad dimensions-Motivation and Pleasure (MAP) and Diminished Expressivity (EXP)-and five lower-level domains. The validity of thes...
Healthy lifestyle, metabolomic signature, and risk of late-onset schizophrenia: evidence from the prospective cohort [0.03%]
健康生活方式、代谢标志物与晚发性精神分裂症风险：前瞻性队列研究证据
Xinru Guo,Ge Yu,Songyu Wu et al.
Xinru Guo et al.
A healthy lifestyle is associated with a reduced risk of schizophrenia, but the underlying metabolic mechanisms remain unclear. The aim of this study was to identify a metabolomic signature of a healthy lifestyle, to assess its mediation be...
Upregulation of DNA repair-related genes in the prefrontal cortex of patients with schizophrenia with low genetic risk [0.03%]
低遗传风险精神分裂症患者额皮质DNA修复相关基因表达上调
Kazusa Miyahara,Mizuki Hino,Risa Shishido et al.
Kazusa Miyahara et al.
Schizophrenia is a heterogeneous disorder, with subpopulations showing a relatively higher heritable predisposition based on many common genetic variants with minimal effects, whereas other subpopulations likely have alternative pathogenic ...
Dose reduction and discontinuation of antipsychotics in psychotic disorders: a systematic review of qualitative studies and meta-synthesis [0.03%]
精神分裂症减药和停用抗精神病药物的系统评价及元合成分析
Sofia Francesca Aprile,Alessandro Rodolico,Antonio Munafò et al.
Sofia Francesca Aprile et al.
Antipsychotic dose reduction and discontinuation are increasingly discussed in the management of psychotic disorders, yet clinical decisions remain challenging and evidence on lived experiences is fragmented. This systematic review and meta...