Joshua Chiappelli,Hongji Chen,Stephanie A Korenic et al.
Joshua Chiappelli et al.
Brain macromolecule signals detected with proton magnetic resonance spectroscopy (MRS) are often regarded as a nuisance, but may be potential markers of pathophysiological processes, such as inflammation, impaired glymphatic clearance, and ...
The role of fear learning in the development of psychosis: an EEG study utilizing a differential fear conditioning paradigm in people with psychotic vulnerability [0.03%]
恐惧学习在精神病发病机制中的作用：一种利用差异性恐惧条件反射范式的EEG研究及其在易感人群中的应用
Metin Özyagcilar,Nilay Esin Ahrens-Demirdal,Anja Riesel et al.
Metin Özyagcilar et al.
By studying how individuals in an "at-risk" state of psychosis learn about threat and safety cues - specifically, how they develop and unlearn fear responses to neutral cues - we might better understand the mechanisms leading to heightened ...
Integrated alterations in inflammation, endothelial function, and extracellular matrix pathways in first-episode drug-naïve schizophrenia [0.03%]
首次发作未经治疗的精神分裂症患者中炎症、内皮功能和细胞外基质通路的整合改变
Qun Yang,Xiaoyu Sun,Sichang Jin et al.
Qun Yang et al.
Objective peripheral biomarkers for early-stage schizophrenia are needed to improve diagnostic accuracy and treatment planning. To identify potential biomarkers, we compared multiple serum factor concentrations between 90 first-episode drug...
Clozapine prescribing in Germany: temporal trends and regional variations, 2012-2022 [0.03%]
德国的氯氮平处方：2012-2022年的趋势和地区差异
Oliver H F Scholle,Oliver Riedel,Mishal Qubad et al.
Oliver H F Scholle et al.
Clozapine is the most effective and only approved drug for treatment-resistant schizophrenia (TRS). Studies based on data up to 2014 concluded that it is underutilized in most industrialized countries, including Germany. Since 2019, nationa...
Alexithymia in schizophrenia spectrum disorders and dissociative disorders: two meta-analytic reviews [0.03%]
分裂症和分离障碍中的类同感缺失：两项元分析研究
Bryan Ho-Wang Yu,Joyce Ho,Suzanne Ho-Wai So
Bryan Ho-Wang Yu
Schizophrenia-spectrum disorders (SSDs) and dissociative disorders (DDs) often co-occur, and both show emotion processing deficits. Alexithymia-comprising difficulty identifying feelings (DIF), difficulty describing feelings (DDF), and exte...
Abnormalities in nitric oxide synthase system function and their association with cognitive function in first-episode schizophrenia patients [0.03%]
首次发作精神分裂症患者一氧化氮合酶系统功能异常及与认知功能的关系
Fei Jiang,Jie Hou,Qun Yang et al.
Fei Jiang et al.
Cognitive deficits are a core feature of schizophrenia, emerging early and strongly influencing functional outcomes. However, the role of the nitric oxide (NO) signaling pathway in drug-naïve, first-episode schizophrenia remains unclear. T...
Generalizability of findings from neurobiological studies of individuals with first-episode psychosis: a cohort study [0.03%]
首发精神病患者神经生物学研究结果的普适性：群组研究
Alexis E Cullen,Maria Lee,Pontus Josefsson et al.
Alexis E Cullen et al.
Using Swedish register data, we estimated the proportion of individuals with first-episode psychosis (FEP) who would be eligible to participate in a typical neurobiological study and found that only 39% met criteria. Eligible and ineligible...
Predictors of conversion to psychosis and mortality in first-episode substance-induced psychosis: a nationwide register-based study in South Korea [0.03%]
韩国全国范围内的登记处基于研究：首次药物诱发的精神病的转变为精神病和死亡率的影响因素预测指标
Yan-Hong Piao,Thi-Hung Le,Ling Li et al.
Yan-Hong Piao et al.
Objective: Substance-induced psychosis (SIP) is associated with a substantial risk of progression to schizophrenia spectrum disorders (SSD), bipolar disorder (BD), and premature mortality. However, evidence from Asia, par...
Spatial disruptions and the embodied Self in schizophrenia: toward a developmental framework [0.03%]
精神分裂症的空间紊乱和具身自我：向发展框架迈进
Andrea Raballo,Antonio Preti,Michele Poletti
Andrea Raballo
Converging evidence indicates that schizophrenia reshapes the embodied structure of subjectivity, profoundly altering how individuals experience their bodies and surrounding space. This Perspective proposes a neurodevelopmental framework li...
Hyperdynamic microtubule-based structural changes in Monocyte-Derived-Neuronal-like cells from patients with schizophrenia [0.03%]
精神分裂症患者的单核细胞来源的神经元样细胞中的微管结构动态变化增强现象研究
Alfredo Bellon,Alonso Cortez-Resendiz,Lauren N Forrest et al.
Alfredo Bellon et al.
A consistent postmortem finding in schizophrenia (SCZ) is reduction in dendrites' size. However, neurons with larger dendritic trees have also been encountered. In vitro experiments with neurons and neuronal-like cells coming directly from ...