Pharmacological rescue of social deficits in rats featuring Disrupted-in-Schizophrenia-1 (DISC1) protein aggregation [0.03%]
药物治疗Disrupted-schizophrenia-1（DISC1）-1蛋白聚集大鼠的社会缺陷问题的研究进展
José Dören,Else Van Gerresheim,Sandra Schäble et al.
José Dören et al.
The pharmacological treatment of negative symptoms in schizophrenia remains a major unmet need. Among these, impairments in social functioning - manifesting as reduced adaptability and social withdrawal - are particularly disabling, as they...
Altered auditory seed-based functional connectivity in other specified schizophrenia spectrum and other psychotic disorder compared to schizophrenia spectrum disorders [0.03%]
其他指定的精神分裂症谱系及其他精神病性障碍与精神分裂症谱系障碍相比的听觉种子基底的功能连接异常
Woo-Sung Kim,Soyolsaikhan Odkhuu,Eun-Jin Jeon et al.
Woo-Sung Kim et al.
Few neuroimaging studies have examined other specified schizophrenia spectrum and other psychotic disorder (OSSO). We sought to identify features differentiating patients with OSSO from those with schizophrenia spectrum disorders (SSD) and ...
The link between GABA levels and P300 abnormalities in schizophrenia spectrum disorders: regional and symptom-based insights [0.03%]
精神分裂症谱系障碍中GABA水平与P300异常之间的联系：区域性及基于症状的见解
Berkhan Karslı,Verena Meisinger,Genc Hasanaj et al.
Berkhan Karslı et al.
According to the excitation-inhibition imbalance theory, GABAergic and glutamatergic systems influence the clinical symptoms, particularly cognitive deficits in schizophrenia spectrum disorders (SSD). These systems have been found disrupted...
SN/VTA neuromelanin signal is associated with subclinical paranoia irrespective of familial risk for psychosis [0.03%]
纹状体黑色素信号与精神病谱系风险无关的亚临床偏执状态有关
Rami Hamati,Nour Kanaa,Bianca Chidiac et al.
Rami Hamati et al.
Subclinical paranoia is present in the relatives of patients with psychosis but it is also relatively common in the general population. Dopamine neurotransmission is increased in people with psychosis and is linked with positive symptoms, s...
Substantia nigra pars reticulata involvement in auditory hallucinations of treatment-resistant schizophrenia: a deep brain stimulation case report [0.03%]
关于难治性精神分裂症听觉幻听的黑质网状部深度脑刺激病例报告
Anruo Shen,Yousef Salimpour,Ankur Butala et al.
Anruo Shen et al.
One-third of schizophrenia patients exhibit treatment resistance, underscoring the need for mechanism-based interventions. We report that deep brain stimulation of the substantia nigra pars reticulata has acutely alleviated persistent audit...
Clinical, social, and economic burdens of schizophrenia in Japan: a targeted literature review [0.03%]
日本 schizophrenia 的临床、社会和经济负担：一份目标文献回顾
Fumiko Ono,Miyu Okamura
Fumiko Ono
Schizophrenia is a severe mental disorder with substantial clinical, economic, and humanistic impacts. This targeted literature review evaluated the burden of schizophrenia on patients and caregivers in Japan. Data were collected from PubMe...
Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders [0.03%]
精神分裂症谱系障碍中听觉皮层N100振幅与T1w / T2w比值的关系
Nora Berz Slapø,Kjetil Nordbø Jørgensen,Stener Nerland et al.
Nora Berz Slapø et al.
Schizophrenia spectrum disorders (SCZspect) are associated with altered function in the auditory cortex (AC), indicated by lower N100 amplitude of the auditory evoked potential (AEP). Although the neural substrate behind lower N100 amplitud...
The relationship between schizophrenia polygenic scores, blood-based proteins and psychosis diagnosis in the UK Biobank [0.03%]
英国生物样本库中精神分裂症多基因评分、血液蛋白与精神病诊断之间的关系
Kimberley M Kendall,Sophie E Legge,Eilidh Fenner et al.
Kimberley M Kendall et al.
Despite notable progress in psychiatric genomics, there are no validated blood-based biomarkers for psychosis. Previous studies have failed to establish a link between schizophrenia polygenic scores (PGS) and blood protein levels. We aimed ...
Social cognitive deficits and their relationship with clinical symptoms in schizophrenia [0.03%]
精神分裂症的社会认知缺陷及其与临床症状的关系研究
Danni He,Douyu Zhang,Yushen Ding et al.
Danni He et al.
While individuals with schizophrenia (SZ) exhibit deficits in social cognition, the specific profile of these deficits across multiple domains and their relationship with clinical symptoms warrants further characterization. This study aimed...
Gender differences in semantic facilitation and verbal recall in schizotypal personality disorder [0.03%]
分裂型人格障碍中的语义启动及言语回忆的性别差异
Martina M Voglmaier,Chandlee C Dickey,Robert W McCarley et al.
Martina M Voglmaier et al.
Previous studies have found that individuals with schizophrenia (SZ) benefit less from semantic context in verbal recall than comparison (HC) subjects. This has not been systematically studied in individuals with schizotypal personality dis...