What is behind the 17-year life expectancy gap between individuals with schizophrenia and the general population? [0.03%]
精神分裂症患者比普通人群平均少活17年，背后原因何在？
Andreea-Violeta Popa,Petru Iulian Ifteni,Daniel Țâbian et al.
Andreea-Violeta Popa et al.
Individuals with schizophrenia face significantly higher mortality rates than the general population, with a typical reduction in life expectancy of 15-20 years. This study investigated 10-year all-cause mortality and its clinical correlate...
Perinatal insult dimensions and developmental trajectories of psychotic-like experiences [0.03%]
围生期损伤维度和类精神病体验的发展轨迹
Eric R Larson,Nicole R Karcher,Alexandra B Moussa-Tooks
Eric R Larson
Perinatal insults (e.g., obstetric complications, substance exposure) are increasing in prevalence and confer risk for psychotic-like experiences in offspring, contributing to a growing public health burden. Perinatal insults often co-occur...
Rui Yuan,Guorui Zhao,Zhe Lu et al.
Rui Yuan et al.
Psychiatric disorders present a significant global health burden with limited effective medications. Observing the widespread comorbidities between diabetes and psychiatric disorders, we explored the potential of repurposing antidiabetic dr...
Longitudinal changes in striatocortical connectivity in first-episode psychosis associated with the emergence of treatment resistance [0.03%]
首次发作精神病相关的治疗抵抗发生的纹状体皮层连接的纵向变化
Angeles Tepper,Javiera Vásquez,Camila Díaz Dellarossa et al.
Angeles Tepper et al.
Treatment resistance affects up to one in four individuals with psychosis in the first few years of illness. However, there is limited information about the brain changes associated with treatment resistance, restricting our ability to deve...
Dynamic brain communication underlying face pareidolia in male schizophrenia [0.03%]
精神分裂症男性患者面孔拟形的脑动态连接机制研究
Valentina Romagnano,Julian Kubon,Alexander N Sokolov et al.
Valentina Romagnano et al.
Faces are essential for effective communication and social interaction. Substantial alterations in face processing are observed in a wide range of mental disorders, in particular, in schizophrenia (SZ). Individuals with SZ experience diffic...
Glymphatic system dysfunction correlated with gut dysbiosis and cognitive impairment in schizophrenia [0.03%]
精神分裂症相关的大脑胶质运输系统功能障碍与肠道菌群失调及认知损害有关
Hui Wu,Bingdong Liu,Weiyin Vivian Liu et al.
Hui Wu et al.
Structural and functional brain abnormalities in schizophrenia (SZ) are well-documented, yet the role of the glymphatic system remains largely unexplored. Given emerging evidence linking the microbiome-gut-brain axis to SZ, this study aims ...
The association between plasma betaine level and brain structural changes in schizophrenia [0.03%]
血浆甜菜碱水平与精神分裂症患者脑结构改变的关系
Favour Omileke,Tempei Ikegame,Shimon Tonsho et al.
Favour Omileke et al.
Previous studies on metabolic profiling have shown decreased plasma levels of betaine in schizophrenia. Betaine serves as a substrate of betaine-homocysteine methyltransferase, which converts homocysteine to methionine. A decrease in betain...
A frame network study of first-episode schizophrenia, ultra-high risk, and healthy populations [0.03%]
首次发作的精神分裂症、高危人群和健康人群的框架网络研究
Zhenmei Zhang,Xiaoqian Ma,Lijun Ouyang et al.
Zhenmei Zhang et al.
Schizophrenia is a complex neuropsychiatric disorder, and the abnormalities in brain networks during its early stages remain incompletely understood. Previously, we identified a stable high-intensity functional network, termed the "Frame Ne...
Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder [0.03%]
精神分裂症谱系障碍患者主动和被动手运动任务中血流动力学反应的时程特征分析
Harun A Rashid,Tilo Kircher,Benjamin Straube
Harun A Rashid
In healthy individuals, active hand-movements typically elicit earlier neural processing than passive one, reflected by more positive contrast estimates of the first-order temporal derivative (TD) of hemodynamic response function (HRF) in f...
Increased intra-subject variability in reward behavior relates to symptom severity in schizophrenia [0.03%]
奖赏行为的组内变异性增加与精神分裂症的症状严重程度相关
I-Fei Chen,Yu-Chen Chan,Chih-Min Liu et al.
I-Fei Chen et al.
Schizophrenia (SZ) is a complex disorder characterized by positive and negative symptoms that have been linked to dysfunction in cognition and reward motivation. Recent findings show higher inter-subject variability in SZ in various cogniti...