A new approach for understanding the association between chronic stress in childhood and psychotic symptoms in schizophrenia patients from mediating role of lncRNA [0.03%]
Zhiyong Mi,Yan Yan,Lingming Kong
Zhiyong Mi
Schizophrenia (SCZ) remains an etiological and therapeutic challenge, this article aims to explore the mediating role of lncRNA between chronic childhood stress and SCZ for providing a scientific basis of SCZ prevention. 200 SCZ patients an...
From neuroinflammation to neural inference: computational psychiatry meets precision medicine [0.03%]
Ghaith K Mansour,Ahmad W Hajjar
Ghaith K Mansour
Psychosis spectrum disorders exhibit substantial clinical variability, necessitating novel frameworks that transcend traditional symptomatic classification. While polygenic risk accounts for significant heritability, the precise mechanisms ...
Helene Speyer,Marte Ustrup,Mette Ødegaard
Helene Speyer
Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis [0.03%]
Anna R Knippenberg,Lawrence H Sweet,Lauren Luther et al.
Anna R Knippenberg et al.
Negative symptoms of psychotic disorders are best represented within a hierarchical structure comprising two broad dimensions-Motivation and Pleasure (MAP) and Diminished Expressivity (EXP)-and five lower-level domains. The validity of thes...
Healthy lifestyle, metabolomic signature, and risk of late-onset schizophrenia: evidence from the prospective cohort [0.03%]
Xinru Guo,Ge Yu,Songyu Wu et al.
Xinru Guo et al.
A healthy lifestyle is associated with a reduced risk of schizophrenia, but the underlying metabolic mechanisms remain unclear. The aim of this study was to identify a metabolomic signature of a healthy lifestyle, to assess its mediation be...
Upregulation of DNA repair-related genes in the prefrontal cortex of patients with schizophrenia with low genetic risk [0.03%]
低遗传风险精神分裂症患者额皮质DNA修复相关基因表达上调
Kazusa Miyahara,Mizuki Hino,Risa Shishido et al.
Kazusa Miyahara et al.
Schizophrenia is a heterogeneous disorder, with subpopulations showing a relatively higher heritable predisposition based on many common genetic variants with minimal effects, whereas other subpopulations likely have alternative pathogenic ...
Dose reduction and discontinuation of antipsychotics in psychotic disorders: a systematic review of qualitative studies and meta-synthesis [0.03%]
精神分裂症减药和停用抗精神病药物的系统评价及元合成分析
Sofia Francesca Aprile,Alessandro Rodolico,Antonio Munafò et al.
Sofia Francesca Aprile et al.
Antipsychotic dose reduction and discontinuation are increasingly discussed in the management of psychotic disorders, yet clinical decisions remain challenging and evidence on lived experiences is fragmented. This systematic review and meta...
Diminished anticipatory-consummatory pleasure interplay in high schizotypal traits and subthreshold depression: potential risk for schizophrenia and depression [0.03%]
高分裂型特质和次阈值抑郁中预期-消费乐趣互动减弱：精神分裂症和抑郁症的风险指标
Lei Shen,Chi Xie,Chang Liu et al.
Lei Shen et al.
Anhedonia is a multidimensional construct encompassing anticipatory and consummatory pleasure, and it manifests across a range of psychiatric disorders including schizophrenia (SCZ) and major depressive disorder (MDD). However, the shared a...
Machine learning-based predictive models and subtypes patterns in peripheral blood of schizophrenia based on a machine learning computational framework [0.03%]
基于机器学习的计算框架的精神分裂症外周血液预测模型和亚型模式研究
Zhijun Li,Qing Sun,Haoyu Li et al.
Zhijun Li et al.
Schizophrenia (SCZ) is a complex psychiatric disorder, and its pathogenic mechanisms are not yet fully understood. The identification of reliable blood biomarkers and molecular subtypes for early diagnosis and effective therapy remains a si...
Rethinking language, cognition and assessment in psychosis: How bilingualism challenges psychiatry and how natural language processing can help [0.03%]
精神病障碍的语言、认知与评估的再思考：双语对精神医学带来的挑战和自然语言处理可能提供的帮助
Sandra Anna Just,Vincent DeLuca,Jason Rothman et al.
Sandra Anna Just et al.
Language plays a central role in the assessment of individuals with psychosis, from taking a medical history to evaluating cognitive function. However, speaking multiple languages can significantly influence linguistic, cognitive and neural...