Looking into the IL-1 of the storm: are inflammasomes the link between immunothrombosis and hyperinflammation in cytokine storm syndromes? [0.03%]
探究风暴中的IL-1：炎性小体是免疫血栓和细胞因子风暴综合征中过度炎症之间的联系吗？
Tara A Gleeson,Erik Nordling,Christina Kaiser et al.
Tara A Gleeson et al.
Inflammasomes and the interleukin (IL)-1 family of cytokines are key mediators of both inflammation and immunothrombosis. Inflammasomes are responsible for the release of the pro-inflammatory cytokines IL-1β and IL-18, as well as releasing...
Adeline Bertola,Alexandre Gallerand,Stoyan Ivanov
Adeline Bertola
Brown adipose tissue (BAT) contains many immune cells. The presence of macrophages, monocytes, dendritic cells, T cells, B cells, and mast cells was documented in BAT. However, in comparison to white adipose tissue, relatively little is kno...
Expression of antimicrobial host defence peptides in the central nervous system during health and disease [0.03%]
健康与疾病状态下中枢神经系统中抗菌宿主防御肽的表达
Katie J Smith,Emily Gwyer Findlay
Katie J Smith
Antimicrobial host defence peptides (HDP) are critical for the first line of defence against bacterial, viral, and fungal pathogens. Over the past decade we have become more aware that, in addition to their antimicrobial roles, they also po...
Stroke-induced changes to immune function and their relevance to increased risk of severe COVID-19 disease [0.03%]
卒中导致的免疫功能变化及其对严重新冠肺炎易感性的潜在影响
Laura McCulloch,Isobel C Mouat,Kieron South et al.
Laura McCulloch et al.
As the COVID-19 pandemic moves towards endemic disease, it remains of key importance to identify groups of individuals vulnerable to severe infection and understand the biological factors that mediate this risk. Stroke patients are at incre...
Signalling mechanisms driving homeostatic and inflammatory effects of interleukin-15 on tissue lymphocytes [0.03%]
白细胞介素-15对组织淋巴细胞稳态和炎症作用的信号机制
Neema Skariah,Olivia J James,Mahima Swamy
Neema Skariah
There is an intriguing dichotomy in the function of cytokine interleukin-15-at low levels, it is required for the homeostasis of the immune system, yet when it is upregulated in response to pathogenic infections or in autoimmunity, IL-15 dr...
Sara Alonso,Karen Edelblum
Sara Alonso
Elucidating the relationship between cellular metabolism and T cell function has substantially advanced our understanding of how T cells are regulated in response to activation. The metabolic profiles of circulating or peripheral T cells ha...
Triphasic production of IFN γ by innate and adaptive lymphocytes following influenza A virus infection [0.03%]
甲型流感病毒感染后固有和适应性淋巴细胞三相产生IFN-γ
George E Finney,Kerrie E Hargrave,Marieke Pingen et al.
George E Finney et al.
Interferon gamma (IFNγ) is a potent antiviral cytokine that can be produced by many innate and adaptive immune cells during infection. Currently, our understanding of which cells produce IFNγ and where they are located at different stages...
CD56bright natural killer cells preferentially kill proliferating CD4+ T cells [0.03%]
增殖的CD4⁺T细胞被CD56⁺亮色自然杀伤细胞优先杀伤
Mercede Lee,Charles J M Bell,Arcadio Rubio Garcia et al.
Mercede Lee et al.
Human CD56br natural killer (NK) cells represent a small subset of CD56+ NK cells in circulation and are largely tissue-resident. The frequency and number of CD56br NK cells in blood has been shown to increase following administration of lo...
Comparative phenotype of circulating versus tissue immune cells in human lung and blood compartments during health and disease [0.03%]
人体健康和疾病状态下肺组织与血液免疫细胞的表型比较研究
Stefano A P Colombo,Sheila L Brown,Matthew R Hepworth et al.
Stefano A P Colombo et al.
The lung is a dynamic mucosal surface constantly exposed to a variety of immunological challenges including harmless environmental antigens, pollutants, and potentially invasive microorganisms. Dysregulation of the immune system at this cru...
The link between T cell activation and development of functionally useful tumour-associated high endothelial venules [0.03%]
T细胞活化与肿瘤相关功能性高内皮微静脉发展的联系研究
Stefan Milutinovic,Awen Gallimore
Stefan Milutinovic
High endothelial venules (HEVs) are specialized postcapillary venules that specifically serve to recruit circulating lymphocytes to secondary lymphoid organs (SLOs) where cognate antigens can be encountered, and immune responses can be init...