Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualization in epithelial tissues [0.03%]
固定点重要：在进行免疫荧光分析前，在固定剂中的持续时间直接影响上皮组织中巨噬细胞的可视化
Lizi M Hegarty,Erin Watson,Calum C Bain et al.
Lizi M Hegarty et al.
Introduction: Macrophages are now recognized as key players in a range of tissues and biological processes, responding to injury and infection, and facilitating development and regeneration. As the importance of macrophag...
Distinct lipid transport proteins are regulated by innate immune stimuli [0.03%]
不同的脂质转运蛋白受固有免疫刺激的调节
Lydia P Tsamouri,Najd M Aljadeed,Antoni Olona et al.
Lydia P Tsamouri et al.
Introduction: Lipid transport plays a critical role in the distribution of lipids across subcellular compartments. This is pivotal during infection and other stress stimuli that increase metabolic demands. While lipid bio...
An autoinflammatory RIG-I variant causing Singleton-Merten syndrome associates with small non-coding Y-RNAs [0.03%]
一个与Singleton-Merten综合征相关联的自体炎症RIG-I变异体与小型非编码Y-RNA关联
Benjamin J Thompson,Christ C P Leemans,Dennis Gravekamp et al.
Benjamin J Thompson et al.
Introduction: The RNA sensor retinoic acid-inducible gene I (RIG-I) performs a critical role in surveying the cytoplasm for the presence of viral nucleic acids and initiating the downstream anti-viral type I interferon pa...
Dendritic-cell diversity in equine blood revealed by single-cell transcriptomics [0.03%]
单细胞转录组揭示马血液中的树突状细胞多样性
Ambre Baillou,Marius Botos,Simone Oberhaensli et al.
Ambre Baillou et al.
Introduction: Detailed classification of equine dendritic cells (DC) is necessary to address various research questions, such as the role of DC subsets in immune-mediated diseases of horses. ...
Region-specific features of early glial activation and Aquaporin-4 dysregulation in conditional mouse models of TDP-43 proteinopathies [0.03%]
TDP-43蛋白病条件性小鼠模型中区域特异性早期胶质活化和Aquaporin-4失调的特征
Gabriela Nieva,Florencia Vassallu,Amaicha Depino et al.
Gabriela Nieva et al.
Introduction: Aggregation and cytoplasmic mislocalization of TDP-43 are key features of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Neuroinflammator...
Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class I [0.03%]
利用肽交换系统研究KIR与HLA-I类分子的肽特异性结合
Tanusya M Murali,Beining Li,Emery Hoos et al.
Tanusya M Murali et al.
Introduction: The killer-cell immunoglobulin-like receptors (KIR) are a family of activating and inhibitory Class I human leukocyte antigen (HLA-I) binding receptors expressed on natural killer (NK) cells and subsets of T...
Profiling of porcine B-cell receptor heavy-chain repertoires indicates the development of a wide public pseudorabies virus-specific immune response after vaccination and challenge [0.03%]
猪B细胞受体重链组库特征分析表明疫苗接种和攻毒后广泛公共伪狂犬病毒特异性免疫反应的发展
Valentin Herbet,Edouard Hirchaud,Yannick Blanchard et al.
Valentin Herbet et al.
Introduction: The antibody repertoire reflects the immune history of an individual. In the present study, we characterized the porcine antibody heavy-chain repertoire following vaccination and challenge with pseudorabies ...
A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory diseases [0.03%]
实验性虹膜炎中的致病CD4 T细胞表型与其他自身免疫性疾病共有的特征
Amy Ward,Oliver H Bell,Luis Martinez-Robles et al.
Amy Ward et al.
Introduction: Murine ocular autoimmunity develops through three stages; prodrome, primary peak, and secondary regulation. During the prodromal phase, leukocytes accumulate within the retina and vitreous. ...
Functional responses of lymphoid stromal cells to Toll-like receptor stimuli in vitro [0.03%]
体外淋巴组织基质细胞对 toll 样受体刺激的功能反应
Isabella Cinti,Kassandra Vezyrgianni,Alice E Denton
Isabella Cinti
Introduction: Lymphoid stromal cells control the spatial organization of lymphoid tissues and respond dynamically during immune reactions, undergoing transcriptional and phenotypic changes that can influence immune respon...
CCR2- T peripheral helper cells as potential coordinators of local immune architecture in human cancer [0.03%]
人癌中的CCR2- T周细胞辅助型T细胞作为潜在的局部免疫结构协调者
Celia Del Carmen Crespo Oliva,Zoé Gerber,Dominique Jean et al.
Celia Del Carmen Crespo Oliva et al.
Introduction: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, yet tumor progression remains a challenge, necessitating improved patient stratification and therapeutic strategies. Tumor growth rel...