Twenty-One Flavors of Type 1 Innate Lymphoid Cells with PD-1 (Programmed Cell Death-1 Receptor) Sprinkles [0.03%]
带有PD-1受体的1型固有淋巴细胞的二十一风味
Katie J Smith,Giuseppe Sciumè,Shoba Amarnath
Katie J Smith
Innate lymphoid cells (ILCs) are tissue-resident immune cells that have been recently implicated in initiating and driving anti-tumor responses. ILCs are classified into three main groups, namely type 1 ILCs (ILC1), type 2 ILCs, and type 3 ...
Friend or Foe - Tc17 cell generation and current evidence for their importance in human disease [0.03%]
朋友或敌人-T细胞受体信号转导在Tc17细胞生成及该类细胞在人类疾病中所扮演角色的当前证据
Anna Veronika Hipp,Bertram Bengsch,Anna-Maria Globig
Anna Veronika Hipp
The term Tc17 cells refers to interleukin 17 (IL-17)-producing CD8+ T cells. While IL-17 is an important mediator of mucosal defense, it is also centrally involved in driving the inflammatory response in immune-mediated diseases, such as ps...
A novel in vitro model of the small intestinal epithelium in co-culture with 'gut-like' dendritic cells [0.03%]
一种与“类似肠”的树突细胞共培养的新型小肠上皮体外模型
Luke J Johnston,Liam Barningham,Eric L Campbell et al.
Luke J Johnston et al.
Cross-talk between dendritic cells (DCs) and the intestinal epithelium is important in the decision to mount a protective immune response to a pathogen or to regulate potentially damaging responses to food antigens and the microbiota. Failu...
Mark Viney,Louise Cheynel
Mark Viney
The gut microbiome is an assemblage of microbes that have profound effects on their hosts. The composition of the microbiome is affected by bottom-up, among-taxa interactions and by top-down, host effects, which includes the host immune res...
Yanan Hu,Svetoslav Chakarov
Yanan Hu
Despite the rising prevalence and costs for the society, obesity etiology, and its precise cellular and molecular mechanisms are still insufficiently understood. The excessive accumulation of fat by adipocytes plays a key role in obesity pr...
Immunotherapy in the context of immune-specialized environment of brain metastases [0.03%]
脑转移免疫微环境下的免疫治疗
Fiona James,Mihaela Lorger
Fiona James
Brain metastases (BrM) develop in 20-40% of patients with advanced cancer. They mainly originate from lung cancer, melanoma, breast cancer, and renal cell carcinoma, and are associated with a poor prognosis. While patients with BrM traditio...
T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces [0.03%]
肠道和皮肤上皮界面的T细胞和细菌微生物群相互作用
Damian Maseda,Silvio Manfredo-Vieira,Aimee S Payne
Damian Maseda
Graphical Abstract. Keywords: T cells; epithelia; microbiota. © The Author(s) 2023. Pu...
Samuele Di Carmine,Molly M Scott,Mairi H McLean et al.
Samuele Di Carmine et al.
Interleukin (IL)-33 is highly expressed in the nucleus of cells present at barrier sites and signals via the ST2 receptor. IL-33 signalling via ST2 is essential for return to tissue homeostasis after acute inflammation, promoting fibrinogen...
Unconventional modes of peptide-HLA-I presentation change the rules of TCR engagement [0.03%]
非常规的肽-HLA-I呈现模式改变了TCR识别的规则
Jade R Hopkins,Bruce J MacLachlan,Stephen Harper et al.
Jade R Hopkins et al.
The intracellular proteome of virtually every nucleated cell in the body is continuously presented at the cell surface via the human leukocyte antigen class I (HLA-I) antigen processing pathway. This pathway classically involves proteasomal...
Revealing stromal and lymphoid sources of Col3a1-expression during inflammation using a novel reporter mouse [0.03%]
利用新型报告基因小鼠在炎症过程中揭示Col3a1表达的间质和淋巴样细胞来源
Larissa C da Rosa,Hannah E Scales,Sangeet Makhija et al.
Larissa C da Rosa et al.
One of the earliest signs of dysregulation of the homeostatic process of fibrosis, associated with pathology in chronic conditions such as rheumatoid arthritis, is the overexpression of collagen type III (COL-3). Critically, there is still ...