Diversification of immunoglobulin genes by gene conversion in the domestic chicken (Gallus gallus domesticus) [0.03%]
家鸡（Gallus gallus domesticus）通过基因转换免疫球蛋白基因的分化
Jessica Mallaby,William Mwangi,Joseph Ng et al.
Jessica Mallaby et al.
Sustainable modern poultry production depends on effective protection against infectious diseases and a diverse range of antibodies is key for an effective immune response. In the domestic chicken, somatic gene conversion is the dominant pr...
The glucocorticoid dexamethasone inhibits HIF-1α stabilization and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages [0.03%]
糖皮质激素地塞米松通过抑制代谢重组来抑制脂多糖刺激的原代巨噬细胞中HIF-1α稳定化
Sally A Clayton,Chloe Lockwood,John D O&#x;Neil et al.
Sally A Clayton et al.
Synthetic glucocorticoids are used to treat many chronic and acute inflammatory conditions. Frequent adverse effects of prolonged exposure to glucocorticoids include disturbances of glucose homeostasis caused by changes in glucose traffic a...
Chi-Ching Tung,Abhay P S Rathore,Ashley L St John
Chi-Ching Tung
Mast cells (MCs) are multifunctional immune cells that express a diverse repertoire of surface receptors and pre-stored bioactive mediators. They are traditionally recognized for their involvement in allergic and inflammatory responses, yet...
Zara Gatt,Utku Gunes,Arianna Raponi et al.
Zara Gatt et al.
Public interest in vaccines is at an all-time high following the SARS-CoV-2 global pandemic. Currently, over 6 billion doses of various vaccines are administered globally each year. Most of these vaccines contain Aluminium-based adjuvants (...
The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype [0.03%]
野生小鼠骨髓具有独特的髓系和淋巴系组成和表型
Andrew Muir,Alex Bennett,Hannah Smith et al.
Andrew Muir et al.
The murine bone marrow has a central role in immune function and health as the primary source of leukocytes in adult mice. Laboratory mice provide a human-homologous, genetically manipulable and reproducible model that has enabled an immeas...
Chiamaka I Chidomere,Mussarat Wahid,Samuel Kemble et al.
Chiamaka I Chidomere et al.
Inflammatory arthritides such as rheumatoid arthritis are a major cause of disability. Pre-clinical murine models of inflammatory arthritis continue to be invaluable tools with which to identify and validate therapeutic targets and compound...
Behind the monocyte's mystique: uncovering their developmental trajectories and fates [0.03%]
揭秘单核细胞的神秘面纱：揭示其发育轨迹和命运走向
Ye Chean Teh,Ming Yao Chooi,Shu Zhen Chong
Ye Chean Teh
Monocytes are circulating myeloid cells that are derived from dedicated progenitors in the bone marrow. Originally thought of as mere precursors for the replacement of tissue macrophages, it is increasingly clear that monocytes execute dist...
Heather M Wilson
Heather M Wilson
Macrophages play a key role in tissue development and homeostasis, innate immune defence against microbes or tumours, and restoring homeostasis through tissue regeneration following infection or injury. The ability to adopt such diverse fun...
Pericardial and mediastinal fat-associated lymphoid clusters are rapidly activated in an alkane-induced model of systemic lupus erythematosus [0.03%]
烷烃诱导系统性红斑狼疮模型中心包和纵隔脂肪相关淋巴样聚簇的快速活化
Karolina Bentkowska,Alex Hardgrave,Nadia Iqbal et al.
Karolina Bentkowska et al.
Systemic lupus erythematosus (SLE) is an autoimmune disease predominated by auto-antibodies that recognise cellular components. Pleural involvement is the most common SLE-related lung disease. Natural antibodies are rapidly secreted by inna...
Sabaria Shah,Abdullah Al-Omari,Katherine W Cook et al.
Sabaria Shah et al.
Complex cellular interactions between the immune system and cancer can impact tumour development, growth, and progression. T cells play a key role in these interactions; however, the challenge for T cells is to recognize tumour antigens whi...