Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1 [0.03%]
HTLV-1的旧朋友视角下的Treg和自身反应性T细胞单细胞谱系分析
Masahiro Ono,Yorifumi Satou
Masahiro Ono
Despite extensive regulatory T cell (Treg) research, fundamental questions on in vivo dynamics remain to be answered. The current study aims to dissect several interwoven concepts in Treg biology, highlighting the 'self-reactivity' of Treg ...
Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success? [0.03%]
生殖道гд Т细胞：生殖成功中的积极参与者还是漠不关心的旁观者？
Kerrie L Foyle,Sarah A Robertson
Kerrie L Foyle
The female reproductive tract accommodates and balances the unique immunological challenges of protection from sexually transmitted pathogens and tolerance of the fetus and placenta in pregnancy. Leukocytes in the female reproductive tract ...
Single-cell RNA sequencing of human lung innate lymphoid cells in the vascular and tissue niche reveals molecular features of tissue adaptation [0.03%]
人肺血管和组织生态位固有淋巴细胞的单细胞RNA测序揭示了组织适应性的分子特征
Arlisa Alisjahbana,Imran Mohammad,Yu Gao et al.
Arlisa Alisjahbana et al.
Innate lymphoid cells (ILCs) are sentinels of healthy organ function, yet it is unknown how ILCs adapt to distinct anatomical niches within tissues. Here, we used a unique humanized mouse model, MISTRG mice transplanted with human hematopoi...
RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression [0.03%]
活化T细胞中RAM的上调及其在RNA帽形成和基因表达方面的功能要求
Katarzyna Knop,Carolina Gomez-Moreira,Alison Galloway et al.
Katarzyna Knop et al.
On T cell activation, upregulation of gene expression produces the protein required for the differentiation and proliferation of effector cell populations. RAM (RNMT-Activating Mini protein/RAMAC/Fam103a1), the cofactor of the RNA cap methy...
Elizabeth Maloney,Darragh Duffy
Elizabeth Maloney
Fever is a hallmark symptom of disease across the animal kingdom. Yet, despite the evidence linking temperature fluctuation and immune response, much remains to be discovered about the molecular mechanisms governing these interactions. In p...
Jiyeon Park,Suk-Jo Kang
Jiyeon Park
Basophils are the rarest leukocytes, but they have essential roles in protection against helminths, allergic disorders, autoimmune diseases, and some cancers. For years, the clinical significance of basophils has been neglected because of t...
Lucia Pedicini,Jessica Smith,Sinisa Savic et al.
Lucia Pedicini et al.
Mast cells are infamous for mediating allergic and inflammatory diseases due to their capacity of rapidly releasing a wide range of inflammatory mediators stored in cytoplasmic granules. However, mast cells also have several important physi...
The effect of abatacept on T-cell activation is not long-lived in vivo [0.03%]
阿巴西普对T细胞活化的抑制作用体内的持续时间短暂
Larissa C da Rosa,Hannah E Scales,Robert A Benson et al.
Larissa C da Rosa et al.
Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the treatment of rheumatoid arthritis. By impairing the interaction between CD28 on T cells and CD80/C...
Optimizing a linear 'Doggybone' DNA vaccine for influenza virus through the incorporation of DNA targeting sequences and neuraminidase antigen [0.03%]
通过融合DNA定位序列和神经氨酸抗原优化线性'Doggybone'流感病毒DNA疫苗
Robert F Cunliffe,David C Stirling,Ilaria Razzano et al.
Robert F Cunliffe et al.
Influenza virus represents a challenge for traditional vaccine approaches due to its seasonal changes and potential for zoonotic transmission. Nucleic acid vaccines can overcome some of these challenges, especially through the inclusion of ...
The association of microbial infection and adaptive immune cell activation in Alzheimer's disease [0.03%]
阿尔茨海默病患者微生物感染与适应性细胞免疫激活之间的关联研究
Mathew Clement
Mathew Clement
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. Early symptoms include the loss of memory and mild cognitive ability; however, as the disease progresses, these symptoms can present ...