How (Eco)immunology can augment global EcoHealth programmes: opportunities, needs, and challenges [0.03%]
生态免疫学如何增强全球生态系统健康计划：机遇、需求和挑战
Sheena M Cruickshank,Kathryn J Else,Iris Mair et al.
Sheena M Cruickshank et al.
Graphical Abstract. Keywords: EcoHealth; ecoimmunology; ecology; immunology; interdisciplinary research. ...
Unravelling monocyte functions: from the guardians of health to the regulators of disease [0.03%]
揭开单核细胞功能的面纱：从健康守护者到疾病的调节者
Alexander Mildner,Ki-Wook Kim,Simon Yona
Alexander Mildner
Monocytes are a key component of the innate immune system. They undergo intricate developmental processes within the bone marrow, leading to diverse monocyte subsets in the circulation. In a state of healthy homeostasis, monocytes are conti...
Identification of a transcription factor network regulating anti-TNF mediated IL10 expression in human CD4+ T cells [0.03%]
人CD4⁺T细胞中鉴别出一个转录因子网络调节抗TNF介导的IL10表达
Giovanni A M Povoleri,Michael L Ridley,Rebecca J Marrow et al.
Giovanni A M Povoleri et al.
CD4+ T cells are key players in immune-mediated inflammatory diseases (IMIDs) through the production of inflammatory mediators including tumour necrosis factor (TNF). Anti-TNF therapy has revolutionized the treatment of several IMIDs and we...
Assessing immune phenotypes using simple proxy measures: promise and limitations [0.03%]
利用简便的替代指标评估免疫表型：前景与局限性
Alexander E Downie,Ramya S Barre,Annie Robinson et al.
Alexander E Downie et al.
The study of immune phenotypes in wild animals is beset by numerous methodological challenges, with assessment of detailed aspects of phenotype difficult to impossible. This constrains the ability of disease ecologists and ecoimmunologists ...
Correction to: Lunar-linked biological rhythms in the immune system of freshwater three-spined stickleback [0.03%]
关于：淡水三刺鱼免疫系统的月球相关生物节律的更正
[This corrects the article DOI: 10.1093/discim/kyae007.]. © The Author(s) 2024. Published by Oxford University Press on behalf of the British Society fo...
Published Erratum
Discovery immunology. 2024 Jul 15;3(1):kyae012. DOI:10.1093/discim/kyae012 2024
Camila Espejo,Vanessa O Ezenwa
Camila Espejo
The immune system is crucial for defending organisms against pathogens and maintaining health. Traditionally, research in immunology has relied on laboratory animals to understand how the immune system works. However, there is increasing re...
Elevated type-17 cytokines are present in axial spondyloarthritis stool [0.03%]
轴型脊柱关节炎患者的粪便中存在升高的类型-17细胞因子
India Brough,Kelsey Thompson,Ciara Latore et al.
India Brough et al.
Axial spondyloarthritis (axSpA) is characterized by type-17 immune-driven joint inflammation, and intestinal inflammation is present in around 70% of patients. In this study, we asked whether axSpA stool contained Th17-associated cytokines ...
IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cells [0.03%]
IL-21使人类γδT细胞呈递抗原以促进幼稚和记忆CD4+T细胞产生IL-10
Christopher J Tyler,Inva Hoti,Daniel D Griffiths et al.
Christopher J Tyler et al.
Direct interaction between T-cells exerts a major influence on tissue immunity and inflammation across multiple body sites including the human gut, which is highly enriched in 'unconventional' lymphocytes such as γδ T-cells. We previously...
Philip P Ahern,Emily Gwyer Findlay
Philip P Ahern
Lunar-linked biological rhythms in the immune system of freshwater three-spined stickleback [0.03%]
与月亮相关的免疫系统的生物节律三刺鱼应急反应
Joseph A Jackson,Alexander Stewart,Joanne Cable
Joseph A Jackson
Immune responses are widely accepted to be under circadian regulation via a molecular clock, with many practical consequences, but much less is known of how other biological rhythms could affect the immune system. In this study, we search f...