The immunological role of oligodendrocytes: beyond myelin maintenance [0.03%]
少突胶质细胞的免疫学作用：超出髓鞘维持的功能
Juana M Pasquini,Jorge D Correale
Juana M Pasquini
Oligodendrocytes (OGDs) are well-established cells in the central nervous system (CNS), primarily recognized for their role in myelination. However, emerging evidence suggests intrinsic differences among OGDs that may lead to diverse functi...
Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs [0.03%]
增殖在维持年轻猪气道驻留记忆T细胞亚群方面起重要作用
Eleni Vatzia,Yan Zhang,Ehsan Sedaghat-Rostami et al.
Eleni Vatzia et al.
Tissue-resident memory (TRM) T cells play an important role in protection against respiratory infection but whether this memory is maintained by long-lived or dividing cells remains controversial. To address the rate of division of lung TRM...
Antonia O Cuff,Ee Von Woon,Thomas Bainton et al.
Antonia O Cuff et al.
Background: Innate lymphoid cells (ILCs) are prominent in the human uterine mucosa and play physiological roles in pregnancy. ILC3 are the second-most common ILC subset in the uterine mucosa, but their role remains unclea...
Iris Mair,Kathryn J Else
Iris Mair
Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience [0.03%]
比较自然化小鼠模型的设置揭示了不同的微生物经验对肠道粘膜产生不同的影响
Henriette Arnesen,Signe Birkeland,Harriet Stendahl et al.
Henriette Arnesen et al.
Introduction: Concerns regarding the translational value of preclinical mouse models have been addressed by introducing various approaches of 'naturalizing' research mice, which provide them with more diverse microbiomes ...
Andrea Woodcock,Ronan Bergin,Nidhi Kedia-Mehta et al.
Andrea Woodcock et al.
Introduction: Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of over 200 chronic co-morbidities, including an increased susceptibility to...
T-helper cell phenotypes are repeatable, positively correlated, and associated with helminth infection in wild Soay sheep [0.03%]
辅助T细胞表型可重复，呈正相关，并与野生Soay绵羊的蠕虫感染有关
Yolanda Corripio-Miyar,Adam D Hayward,Hannah Lemon et al.
Yolanda Corripio-Miyar et al.
Background: T-helper (Th) cells co-ordinate immune responses to ensure that infections with diverse parasites are controlled effectively. Helminth parasites such as gastrointestinal nematodes (GIN) are generally associate...
The current landscape of optogenetics for the enhancement of adoptive T-cell therapy [0.03%]
光遗传学优化过继T细胞治疗的现状
George R Smith,Max P Lee,Emma K Jennings et al.
George R Smith et al.
Immunotherapy, the medicinal modulation of a host's immune response to better combat a pathogen or disease, has transformed cancer treatments in recent decades. T-cells, an important component of the adaptive immune system, are further para...
Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis [0.03%]
程序性死亡受体1基因敲除小鼠肝内新型遗传变异引起的肉芽肿炎症反应
Ilamangai Nagaretnam,Yoshiya Kakimoto,Azusa Yoneshige et al.
Ilamangai Nagaretnam et al.
Introduction: Programmed death-1 (PD-1) is a negative regulator of immune responses. Upon deletion of PD-1 in mice, symptoms of autoimmunity developed only after they got old. In a model experiment in cancer immunotherapy...
The sedoheptulose kinase CARKL controls T-cell cytokine outputs and migration by promoting metabolic reprogramming [0.03%]
天冬氨酸激酶CARKL通过促进代谢重构控制T细胞细胞因子产生和迁移
Michelangelo Certo,Jennifer Niven,Robert Haas et al.
Michelangelo Certo et al.
Background: Immunometabolism is a crucial determinant of immune cell function, influencing cellular activation and differentiation through metabolic pathways. The intricate interplay between metabolism and immune response...